Results 61 to 70 of about 7,425 (206)

Diagnosis and treatment of occipital brain lesions in children

Developmental Medicine &Child Neurology, Volume 67, Issue 11, Page 1409-1420, November 2025.
Occipital brain lesions in children represent a diagnostic challenge due to the large spectrum of etiologies and overlapping clinical features. This review analyses common and less common causes of occipital brain lesions in children, including malformative, vascular, genetic/metabolic, infectious, inflammatory, and neoplastic conditions.
Luca Bartolini, Giulia Savoca, Matteo Tassone, Tiziana Metitieri, Renzo Guerrini   +4 more
wiley   +1 more source

Rapid and Simple Dispersive Liquid–Liquid Microextraction (DLLME) Sample Preparation for Propofol Analysis in Hair, Blood, and Urine by Gas Chromatography–Mass Spectrometry

Drug Testing and Analysis, Volume 17, Issue 9, Page 1528-1536, September 2025.
Development and validation of an extraction method based on dispersive liquid–liquid microextraction for the analysis by GC–MS of propofol in three different biological samples (blood, urine, and hair). The proposed method is very simple and rapid.
Sara Odoardi, Serena Mestria, Valeria Valentini, Giulia Biosa, Sabina Strano Rossi   +4 more
wiley   +1 more source

Chondroitin sulfate degradation and eicosanoid metabolism pathways are impaired in focal segmental glomerulosclerosis: Experimental confirmation of an in silico prediction [PDF]

BioImpacts, 2019
Introduction: Focal segmental glomerulosclerosis (FSGS), the most common primary glomerular disease, is a diverse clinical entity that occurs after podocyte injury.
Shiva Kalantari, Mohammad Naji, Mohsen Nafar, Hootan Yazdani-Kachooei, Nasrin Borumandnia, Mahmoud Parvin   +5 more
doaj   +1 more source

ARSA Variants Associated With Cognitive Decline and Long‐Term Preservation of Motor Function in Metachromatic Leukodystrophy

Journal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.
ABSTRACT Patients with metachromatic leukodystrophy (MLD) show variable motor and cognitive decline. The ARSA variants c.256C>T, p.(Arg86Trp), c.257G>A, p.(Arg86Gln) and c.542T>G, p.(Ile181Ser) are associated with predominantly cognitive decline. This multinational study analyzed MLD onset type, presenting signs/symptoms, cognitive function, gross ...
Shanice Beerepoot, Daphne H. Schoenmakers, Francesca Fumagalli, Samuel Groeschel, Ludger Schöls, Raphael Schiffmann, Sheila Wong, Odile Boespflug‐Tanguy, Caroline Sevin, Yann Nadjar, Annette Bley, Fanny Mochel, Morten A. Horn, Cristina Baldoli, Sara Locatelli, Holger Hengel, Lucia Laugwitz, Carla E. M. Hollak, Volkmar Gieselmann, Marjo S. van der Knaap, Nicole I. Wolf   +20 more
wiley   +1 more source

Soil organic matter and enzyme activity in tropical sandy soils under integrated and conventional land uses

Soil Science Society of America Journal, Volume 89, Issue 5, September/October 2025.
Abstract The preservation of soil fertility is essential for ecosystem sustainability, particularly in tropical regions where agricultural intensification often leads to rapid degradation. This study evaluated the impact of different land‐use systems on soil organic matter (SOM), enzymatic activities, and soybean productivity in tropical sandy soils ...
Karini Aparecida Matos Inacio, Aureo Henrique Hubinger Fonseca, Gustavo Henrique Chaves Matos Trovato, Alexandre Alonso Oliveira, Rienni Paula Queiroz, Márcio Lustosa Santos, Munir Mauad, Elcio Ferreira Santos   +7 more
wiley   +1 more source

Cloning and Expression of Human Arylsulfatase A

Journal of Biological Chemistry, 1989
A full length cDNA for human arylsulfatase A was cloned and sequenced. The predicted amino acid sequence comprises 507 residues. A putative signal peptide of 18 residues is followed by the NH2-terminal sequence of placental arylsulfatase A. One of the arylsulfatase A peptides ends 3 residues ahead of the predicted COOH terminus.
C, Stein, V, Gieselmann, J, Kreysing, B, Schmidt, R, Pohlmann, A, Waheed, H E, Meyer, J S, O'Brien, K, von Figura   +8 more
openaire   +2 more sources

Diverse Cooccurring Metabolisms Support Sulfur and Methane Cycling in Wetland Surficial Sediments

Journal of Geophysical Research: Biogeosciences, Volume 130, Issue 9, September 2025.
Abstract The Prairie Pothole Region (PPR) of North America contains millions of small depressional wetlands with some of the highest methane (CH4) fluxes ever reported in terrestrial ecosystems. In saturated soils, two conventional paradigms are (a) methanogenesis is the final step in the redox ladder, occurring only after more thermodynamically ...
Emily K. Bechtold, Danhui Xin, Maricia Pacheco, Brandy M. Toner, William A. Arnold, Yu‐Ping Chin, Michael J. Wilkins   +6 more
wiley   +1 more source

Activation Energy of Organic Matter Decomposition in Soil and Consequences of Global Warming

Global Change Biology, Volume 31, Issue 9, September 2025.
Activation energy (Ea) is the minimum energy necessary for (bio)chemical reactions defining reaction rates, e.g., organic matter transformations in soil. Based on the Ea database of enzyme activities, CO2 production, heat release during soil incubation, and thermal oxidation of soil organic matter, we assess the Ea of biotic and abiotic transformation ...
Ekaterina Filimonenko, Yakov Kuzyakov
wiley   +1 more source

UHPLC‐QTOFMS Urine Drug Screening With Dilute‐and‐Shoot Sample Preparation and Vacuum‐Insulated Probe‐Heated Electrospray Ionization

Drug Testing and Analysis, Volume 17, Issue 8, Page 1208-1218, August 2025.
The new ionization technique, vacuum‐insulated probe‐heated electrospray, allows for a simple dilute‐and‐shoot sample preparation to be used with liquid chromatography time‐of‐flight mass spectrometry in urine drug screening. Comparison with a method relying on solid‐phase extraction and conventional electrospray ionization shows improved performance ...
Mira Sundström, Pirkko Kriikku, Ilkka Ojanperä, Carsten Baessmann, Anna Pelander   +4 more
wiley   +1 more source

Characterizing Diagnostic Delays in Metachromatic Leukodystrophy: A Real‐World Data Approach

Journal of Inherited Metabolic Disease, Volume 48, Issue 4, July 2025.
ABSTRACT Neurodegeneration in metachromatic leukodystrophy (MLD) may be preceded by systemic complications. Characterization of these features is critical to define barriers to early diagnosis and treatment eligibility for gene therapy. We utilized medical billing (claims) datasets and a natural history study to capture pre‐diagnosis MLD‐related events.
Ali Mohajer, Anjana Sevagamoorthy, Karen Bean, Sylvia Mutua, Francis Pang, Laura Ann Adang   +5 more
wiley   +1 more source