Results 51 to 60 of about 5,708 (209)

Non‐neutralizing antibody responses following A(H1N1)pdm09 influenza vaccination with or without AS03 adjuvant system [PDF]

Influenza and Other Respiratory Viruses, 2020
AbstractBackgroundNon‐neutralizing antibodies inducing complement‐dependent lysis (CDL) and antibody‐dependent cell‐mediated cytotoxicity (ADCC) activity may contribute to protection against influenza infection. We investigated CDL and ADCC responses in healthy adults randomized to receive either non‐adjuvanted or AS03‐adjuvanted monovalent A(H1N1 ...
Damien Friel, Mary Co, Thierry Ollinger, Bruno Salaun, Anne Schuind, Ping Li, Karl Walravens, Francis A. Ennis, David W. Vaughn   +8 more
openaire   +3 more sources

Programmable Antigen‐Specific Immunity via Self‐Adjuvanting Nanovaccines Co‐Delivering Immune Modulators

Angewandte Chemie, EarlyView.
The self‐adjuvanting vaccine—comprising a covalent conjugate of antigen and adjuvant—was formulated into cationic lipid nanoparticles smaller than 100 nm to facilitate uptake by immune cells, with supplemental adjuvants incorporated to modulate immune responses.
Keita Ito, Yoshiyuki Manabe, Shino Ohshima, Masatoshi Maeki, Manabu Tokeshi, Hiroshi Inaba, Kazunori Matsuura, Kazuya Kabayama, Yoshie Kametani, Koichi Fukase   +9 more
wiley   +2 more sources

Evaluation of the potential effects of AS03-adjuvanted A(H1N1)pdm09 vaccine administration on the central nervous system of non-primed and A(H1N1)pdm09-primed cotton rats

Human Vaccines & Immunotherapeutics, 2017
An increased risk of narcolepsy following administration of an AS03-adjuvanted A(H1N1)pdm09 pandemic influenza vaccine (Pandemrix™) was described in children and adolescents in certain European countries.
Camille Planty, Corey P. Mallett, Kevin Yim, Jorge C. G. Blanco, Marina Boukhvalova, Thomas March, Robbert van der Most, Eric Destexhe   +7 more
doaj   +1 more source

Safety of AS03-adjuvanted split-virion H1N1 (2009) pandemic influenza vaccine: a prospective cohort study [PDF]

BMJ Open, 2013
ObjectivesTo assess the safety of an AS03-adjuvanted split virion H1N1 (2009) vaccine (Pandemrix) in persons vaccinated during the national pandemic influenza vaccination campaign in the UK.DesignProspective, cohort, observational, postauthorisation safety study.Setting87 general practices forming part of the Medical Research Council General Practice ...
Nazareth, Irwin, Tavares, Fernanda, Rosillon, Dominique, Haguinet, François, Bauchau, Vincent   +4 more
openaire   +2 more sources

Different Adjuvants Induce Common Innate Pathways That Are Associated with Enhanced Adaptive Responses against a Model Antigen in Humans

Frontiers in Immunology, 2017
To elucidate the role of innate responses in vaccine immunogenicity, we compared early responses to hepatitis B virus (HBV) surface antigen (HBsAg) combined with different Adjuvant Systems (AS) in healthy HBV-naïve adults, and included these parameters ...
Wivine Burny, Andrea Callegaro, Viviane Bechtold, Frédéric Clement, Sophie Delhaye, Laurence Fissette, Michel Janssens, Geert Leroux-Roels, Arnaud Marchant, Robert A. van den Berg, Nathalie Garçon, Robbert van der Most, Arnaud M. Didierlaurent, On Behalf of the ECR-002 Study Group, Viviane Bechtold, Wivine Burny, Andrea Callegaro, Isabelle Carletti, Frédéric Clement, Sophie Delhaye, Arnaud Didierlaurent, Meral Esen, Laurence Fissette, Julian Gabor, Nathalie Garçon, Edwige Haelterman, Caroline Hervé, Yves Horsmans, Michel Janssens, Peter Kremsner, Geert Leroux-Roels, Arnaud Marchant, Philippe Moris, Tino F Schwarz, Fernanda Tavares da Silva, Pascale Van Belle, Pierre Van Damme, Robert A. van den Berg, Robbert van der Most, Dirk Zuchner   +39 more
doaj   +1 more source

A Characterization of Morphic Words with Polynomial Growth

, 2020
A morphic word is obtained by iterating a morphism to generate an infinite word, and then applying a coding. We characterize morphic words with polynomial growth in terms of a new type of infinite word called a $\textit{zigzag word}$.
Smith, Tim
core   +1 more source

Vaccination with SARS-CoV-2 Spike Protein and AS03 Adjuvant Induces Rapid Anamnestic Antibodies in the Lung and Protects Against Virus Challenge in Nonhuman Primates

bioRxiv, 2021
Adjuvanted soluble protein vaccines have been used extensively in humans for protection against various viral infections based on their robust induction of antibody responses.
J. Francica, Barbara Flynn, K. Foulds, Amy T. Noe, Anne P. Werner, Ian N. Moore, M. Gagne, T. Johnston, C. Tucker, Rachel L. Davis, B. Flach, S. O'connell, Shayne F. Andrew, Evan Lamb, Dillon R. Flebbe, S. Nurmukhambetova, M. Donaldson, J. Todd, A. Zhu, C. Atyeo, S. Fischinger, M. Gorman, Sally A. Shin, V. Edara, K. Floyd, L. Lai, Alida Tylor, Elizabeth McCarthy, V. Lecouturier, Sophie Ruiz, C. Berry, T. Tibbitts, H. Andersen, Anthony Cook, A. Dodson, Laurent Pessaint, Alex Van Ry, M. Koutsoukos, C. Gutzeit, I-Ting Teng, T. Zhou, Dapeng Li, B. Haynes, P. Kwong, A. McDermott, M. Lewis, T. Fu, R. Chicz, R. G. van der Most, Kizzmekia S. Corbett, M. Suthar, G. Alter, M. Roederer, N. Sullivan, D. Douek, B. Graham, D. Casimiro, R. Seder   +57 more
semanticscholar   +1 more source

Robust induction of functional humoral response by a plant-derived Coronavirus-like particle vaccine candidate for COVID-19

npj Vaccines, 2023
Despite the success of existing COVID-19 vaccine platforms, the persistent limitations in global deployment of vaccines and waning immunity exhibited by many of the currently deployed vaccine platforms have led to perpetual outbreaks of SARS-CoV-2 ...
Paulina Kaplonek, Deniz Cizmeci, Jessica Shih-Lu Lee, Sally A. Shin, Stephanie Fischinger, Philipe Gobeil, Stéphane Pillet, Nathalie Charland, Brian J. Ward, Galit Alter   +9 more
doaj   +1 more source

Investigating the effect of AS03 adjuvant on the plasma cell repertoire following pH1N1 influenza vaccination [PDF]

Scientific Reports, 2016
AbstractInfluenza pandemics require rapid deployment of effective vaccines for control. Adjuvants such as AS03 improve vaccine immunogenicity, but this mechanism is poorly understood. We used high-throughput B cell receptor sequencing of plasma cells produced following AS03-adjuvanted and non-adjuvanted 2009 pandemic H1N1 vaccination, as well as pre ...
Galson, J D, Trück, Johannes, Kelly, D F, van der Most, R   +3 more
openaire   +3 more sources

Relative Efficacy of AS03-Adjuvanted Pandemic Influenza A(H1N1) Vaccine in Children: Results of a Controlled, Randomized Efficacy Trial [PDF]

, 2014
Background. the vaccine efficacy (VE) of 1 or 2 doses of AS03-adjuvanted influenza A(H1N1) vaccine relative to that of 2 doses of nonadjuvanted influenza A(H1N1) vaccine in children 6 months to
Borja-Tabora, Charissa, Breuer, Thomas, Cruz-Valdez, Aurelio, Dubin, Gary, Durviaux, Serge, Faingezicht, Idis, Fries, Louis, Hernandez-de Mezerville, Marcela, Innis, Bruce L., Kerdpanich, Angkool, Kosuwon, Pensri, Lazcano-Ponce, Eduardo, Li, Ping, Lim, Fong Seng, Litao, Sandra, Lopez, Pio, Mascarenas de Los Santos, Abiel, Montellano, May, Nolan, Terry, Palazzi Safadi, Marco Aurelio, Rodriguez Weber, Miguel Angel, Roy-Ghanta, Sumita, Tinoco, Juan-Carlos, Ulloa-Gutierrez, Rolando, Vaughn, David W., Weckx, Lily   +25 more
core   +3 more sources