Results 41 to 50 of about 3,001 (154)

Safety and immunogenicity of an AS03-adjuvanted plant-based SARS-CoV-2 vaccine in Adults with and without Comorbidities

npj Vaccines, 2022
The rapid spread of SARS-CoV-2 continues to impact humanity on a global scale with rising total morbidity and mortality. Despite the development of several effective vaccines, new products are needed to supply ongoing demand and to fight variants.
Nathalie Charland, Philipe Gobeil, Stéphane Pillet, Iohann Boulay, Annie Séguin, Alexander Makarkov, Gretchen Heizer, Kapil Bhutada, Asif Mahmood, Sonia Trépanier, Karen Hager, Julia Jiang-Wright, Judith Atkins, Pooja Saxena, Matthew P. Cheng, Donald C. Vinh, Philippe Boutet, François Roman, Robbert Van Der Most, Maria Angeles Ceregido, Marc Dionne, Guy Tellier, Jean-Sébastien Gauthier, Brandon Essink, Michael Libman, Jason Haffizulla, André Fréchette, Marc-André D’Aoust, Nathalie Landry, Brian J. Ward   +29 more
doaj   +1 more source

AS03-adjuvanted H5N1 vaccination resulted in increased cell cycle responses in NK-cells relative to non-adjuvanted vaccine 3 days post-vaccination.

, 2017
The pathway map is based on the KEGG Cell cycle pathway. Pathway node color gradient encodes log2 fold change difference (LFCD) between vaccine groups (for multi-gene nodes the median LFCD is used).
Heather Hill (3666856), Allison Galassie (694630), Kathryn M. Edwards (534416), Leigh M. Howard (694627), Laura E. Gordy (353375), Sebastian Joyce (353377), Shawn E. Levy (694633), Tara M. Allos (694631), Xinnan Niu (694628), Nripesh Prasad (694629), Travis L. Jensen (3666853), Johannes B. Goll (495915), Andrew J. Link (366977), C. Buddy Creech (748289), Kristen L. Hoek (694625), Parimal Samir (694626)   +15 more
core   +1 more source

AS03-adjuvanted, very-low-dose influenza vaccines induce distinctive immune responses compared to unadjuvanted high-dose vaccines in BALB/c mice

Frontiers in Immunology, 2015
During the 2009-2010 influenza pandemic, an adjuvanted, dose-sparing vaccine was recommended for most Canadians. We hypothesize that differences exist in the responses to AS03-adjuvanted, low antigen (Ag) dose versus unadjuvanted, full-dose vaccines.
Karen K Yam, Jyotsana eGupta, Kaitlin eWinter, Elizabeth eAllen, Angela eBrewer, Édith eBeaulieu, Corey P Mallett, David S Burt, Brian J Ward, Brian J Ward   +9 more
doaj   +1 more source

Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice

npj Vaccines, 2022
Adjuvants enhance the magnitude and the durability of the immune response to vaccines. However, there is a paucity of comparative studies on the nature of the immune responses stimulated by leading adjuvant candidates.
Lilit Grigoryan, Audrey Lee, Alexandra C. Walls, Lilin Lai, Benjamin Franco, Prabhu S. Arunachalam, Yupeng Feng, Wei Luo, Abigail Vanderheiden, Katharine Floyd, Samuel Wrenn, Deleah Pettie, Marcos C. Miranda, Elizabeth Kepl, Rashmi Ravichandran, Claire Sydeman, Natalie Brunette, Michael Murphy, Brooke Fiala, Lauren Carter, Robert L. Coffman, David Novack, Harry Kleanthous, Derek T. O’Hagan, Robbert van der Most, Jason S. McLellan, Mehul Suthar, David Veesler, Neil P. King, Bali Pulendran   +29 more
doaj   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Activation of the endoplasmic reticulum stress sensor IRE1α by the vaccine adjuvant AS03 contributes to its immunostimulatory properties

, 2018
The oil-in-water emulsion Adjuvant System 03 (AS03) is one of the few adjuvants used in licensed vaccines. Previous work indicates that AS03 induces a local and transient inflammatory response that contributes to its adjuvant effect.
Leo, Oberdan, Perez-Morga, David, Didierlaurent, Arnaud, Lima Silva, Viviana, Didierlaurent, Arnaud M, Givord, Charlotte, Welsby, Iain, Oberdan Leo, Romain Gineste, Assiya Assabban, Marjorie Vermeersch, Charlotte Givord, Detienne, Sophie, Vermeersch, Marjorie, Gineste, Romain, Céline Molle, Sophie Detienne, Assabban, Assiya, Goriely, Stanislas, Stanislas Goriely, Molle, Céline, Séverine Thomas, Collignon, Catherine, Thomas, Séverine, Arnaud M. Didierlaurent, Iain Welsby, David Perez-Morga, Viviana Lima Silva, Catherine Collignon   +28 more
core   +1 more source

Selection of an adjuvant for seasonal influenza vaccine in elderly people : modelling immunogenicity from a randomized trial [PDF]

, 2013
Background: Improved influenza vaccines are needed to reduce influenza-associated complications in older adults. The aim of this study was to identify the optimal formulation of adjuvanted seasonal influenza vaccine for use in elderly people.
Pauksens, Karlis,, Rumke, Hans C., Jan Hendrik Richardus, Lidia Oostvogels, Richardus, Jan Hendrik, Karlis Pauksens, Durand, Christelle, Hans C Rümke, Oostvogels, Lidia, Pauksens, K, Plassmann, Georg, Georg Plaßmann, Rumke, HC, Dewe, W, Jeanne-Marie Devaster, Devaster, JM, Oostvogels, L, Rombo, Lars,, Lars Rombo, Walthère Dewé, Rombo, L, Rombo, Lars, Christelle Durand, Richardus, Jan hendrik; id_orcid, Pauksens, Karlis, Plassmann, G, Durand, CML (Charles), Dewe, Walthere, Devaster, Jeanne-Marie   +28 more
core   +2 more sources

Programmable Antigen‐Specific Immunity via Self‐Adjuvanting Nanovaccines Co‐Delivering Immune Modulators

Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.
The self‐adjuvanting vaccine—comprising a covalent conjugate of antigen and adjuvant—was formulated into cationic lipid nanoparticles smaller than 100 nm to facilitate uptake by immune cells, with supplemental adjuvants incorporated to modulate immune responses.
Keita Ito, Yoshiyuki Manabe, Shino Ohshima, Masatoshi Maeki, Manabu Tokeshi, Hiroshi Inaba, Kazunori Matsuura, Kazuya Kabayama, Yoshie Kametani, Koichi Fukase   +9 more
wiley   +2 more sources

Whole‐blood cytokine secretion assay as a high‐throughput alternative for assessing the cell‐mediated immunity profile after two doses of an adjuvanted SARS‐CoV‐2 recombinant protein vaccine candidate

Clinical & Translational Immunology, 2022
Objectives We previously described the Phase I‐II evaluation of SARS‐CoV‐2 recombinant protein candidate vaccine, CoV2‐PreS‐dTM, with AF03‐ or AS03‐adjuvant systems (ClinicalTrials.gov, NCT04537208).
Stephen C De Rosa, Kristen W Cohen, Matthew Bonaparte, Bo Fu, Sanjay Garg, Catherine Gerard, Paul A Goepfert, Ying Huang, Daniel Larocque, M. Juliana McElrath, Daryl Morris, Robbert Van der Most, Guy deBruyn, Anke Pagnon   +13 more
doaj   +1 more source

Inflorescence Photosynthesis Determines Resource Allocation, Seed Production and Senescence in an Agricultural Weed

Plant, Cell &Environment, EarlyView.
ABSTRACT Agricultural weeds typically combine high reproductive output with fast vegetative growth. Here we analyzed the processes that overcome a potential trade‐off between vegetative growth and reproduction in the weed Avena fatua. We determined photosynthetic function of inflorescences and analyzed the transcriptomes of individual inflorescence ...
Soualihou Soualiou, Lucía Guerrero Cornejo, Israel Ikoyi, Rossana Henriques, Astrid Wingler   +4 more
wiley   +1 more source