Results 51 to 60 of about 3,001 (154)

Trained Immunity in Childhood Vaccination

Acta Paediatrica, Volume 115, Issue 11, Page 2402-2413, November 2026.
Trained immunity as an emerging concept in paediatric vaccinology. Trained immunity links vaccine stimuli through epigenetic and metabolic reprogramming to enhanced innate immune cell function, thereby strengthening protection against diverse pathogens while promoting adaptive immune responses through more efficient antigen presentation and co ...
ChenRongRong Cai, Lubnaa Hossenbaccus, Eva Kaufmann   +2 more
wiley   +1 more source

Relative efficacy of AS03-adjuvanted pandemic influenza A(H1N1) vaccine in children: Results of a controlled, randomized efficacy trial [PDF]

, 2014
BACKGROUND: The vaccine efficacy (VE) of 1 or 2 doses of AS03-adjuvanted influenza A(H1N1) vaccine relative to that of 2 doses of nonadjuvanted influenza A(H1N1) vaccine in children 6 months to
Li, P, Fries, L, Ulloa-Gutierrez, R, Faingezicht, I, Weber, MAR, Nolan, T, Mezerville, MHD, De Los Santos, AM, Tinoco, JC, Borja-Tabora, C, Weckx, L, Litao, S, Breuer, T, Kosuwon, P, Durviaux, S, Lazcano-Ponce, E, Dubin, G, Roy-Ghanta, S, Lopez, P, Vaughn, DW, Cruz-Valdez, A, Lim, FS, Kerdpanich, A, Montellano, M, Innis, BL, Safadi, MAP   +25 more
core   +1 more source

Comparison of adverse events following immunization with pandemic influenza A (H1N1)pdm09 vaccine with or without adjuvant among health professionals in Rio de Janeiro, Brazil

Memorias do Instituto Oswaldo Cruz, 2012
A vaccination campaign against pandemic influenza A (H1N1)pdm09 was held in Brazil in March 2010, using two types of monovalent split virus vaccines: an AS03-adjuvanted vaccine and a non-adjuvanted vaccine.
José Cerbino-Neto, Ananza Tainá da Silva Santos, Maria Isabel Fragoso da Silveira Gouvea, Renata Saraiva Pedro, Grazielle Viana Ramos, Lusiele Guaraldo, Guilherme Loureiro Werneck   +6 more
doaj   +1 more source

GC B Cells, Tfh Cells, and Influenza bnAbs: Insights for Improving Universal Vaccine Design

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Antibodies are crucial for providing protection against influenza virus infection; however, protective humoral immunity is limited by antigenic drift and shift. Hence, the discovery of broadly neutralizing antibodies (bnAbs) targeting conserved epitopes on hemagglutinin protein evokes the hope of developing a universal influenza vaccine ...
Takeshi Inoue, Wataru Ise, Tomohiro Kurosaki   +2 more
wiley   +1 more source

Modulating Membrane Surface Properties via Prewetting With Polysorbate 20 to Improve Sterile Filtration of Nanoemulsions

Biotechnology Journal, Volume 21, Issue 7, July 2026.
Graphical Abstract and Lay Summary Nanoemulsions are promising vaccine adjuvants and drug delivery vehicles. In this work, we have demonstrated that sterile filtration performance can be significantly enhanced by prewetting the sterile filter with Polysorbate 20 to increase the hydrophilicity of the sterile filter.
Shreya Kapila, Milea M. Osmanski, Randal J. Soukup, Marissa E. Bradley, David Boyd, Andrew L. Zydney   +5 more
wiley   +1 more source

A phase II, open-label, multicentre study to evaluate the immunogenicity and safety of an adjuvanted prepandemic (H5N1) influenza vaccine in healthy Japanese adults

BMC Infectious Diseases, 2010
Background Promising clinical data and significant antigen-sparing have been demonstrated for a pandemic H5N1 influenza split-virion vaccine adjuvanted with AS03A, an α-tocopherol-containing oil-in-water emulsion-based Adjuvant System.
Dramé Mamadou, Maeda Atsushi, Tenjinbaru Kazuyoshi, Ikematsu Hideyuki, Nagai Hideaki, Roman François P   +5 more
doaj   +1 more source

De Novo Synthesis in Cancer Immunotherapy: Applications and Prospects

MedComm, Volume 7, Issue 7, July 2026.
De novo protein design creates novel structures for cancer immunotherapy, integrating rational design principles like modularity and specificity. Leveraging computational tools, it optimizes cytokine engineering, adoptive cellular therapy, and checkpoint regulation to enhance antitumor immunity.
Yang Jin, Yanfeng Wu, Jianhua Luo
wiley   +1 more source

Strong serological responses and HIV RNA increase following AS03-adjuvanted pandemic immunization in HIV-infected patients

, 2012
We aimed to determine the antibody responses and effect on viral load of the AS03-adjuvanted pandemic H1N1 vaccine in HIV-infected ...
Combescure, Christophe, Kaiser, Laurent, Bel, Michael, Hirschel, Bernard, Siegrist, Claire-Anne, Calmy, Alexandra, Yerly Ferrillo, Sabine, Villard, Jean, H1N1 study group, Delhumeau-Cartier, Cécile, Meier, Sara, Nguyen, A, Meier S, Bel M, Combescure C, Delhumeau C, Hirschel B, Siegrist CA, Calmy A, Nguyen A, Yerly S, Kaiser L   +21 more
core   +1 more source

Post-pandemic seroprevalence of pandemic influenza A (H1N1) 2009 infection (swine flu) among children <18 years in Germany. [PDF]

, 2011
We determined antibodies to the pandemic influenza A (H1N1) 2009 virus in children to assess: the incidence of (H1N1) 2009 infections in the 2009/2010 season in Germany, the proportion of subclinical infections and to compare titers in vaccinated and ...
Thomas Mertens, Andrea Streng, Niehues Tim, Stephan Wirth, Rüdiger von Kries, Hampl, Walter, Michel, Detlef, Shai, Sonu, Falkenhorst, Gerhard, Kaiser, Petra, Weiss Susanne, von Kries, Rüdiger, Walter Hampl, Schroten Horst, König, Carl-Heinz Wirsing von, Tenenbaum, Tobias, Niehues, Tim, Peters, Jochen, Carl Heinz Wirsing von König, Tobias Tenenbaum, Susanne Weiss, Petra Kaiser, Wirsing von Koenig, Carl Heinz, Hans-Iko Huppertz, Ellen Kuscher, Mertens Thomas, Hermann Girschick, Weiss, Susanne, Wirsing von König, Carl-Heinz, Tim Niehues, Huppertz, Hans-Iko, Simon Rückinger, Streng, Andrea, Kries, Rüdiger von, Kaiser Petra, Horst Schroten, Sonu Shai, Falkenhorst Gerhard, Wirsing von König Carl Heinz, Axel Sauerbrey, Liese, Johannes, Johannes Liese, Mertens, Thomas, Rückinger Simon, Hampl Walter, Schroten, Horst, Sauerbrey, Axel, Gerhard Falkenhorst, Shai Sonu, Huppertz Hans-Iko, von Kries Rüdiger, Rückinger, Simon, Tenenbaum Tobias, Jochen Peters, Wirth Stephan, Liese Johannes, Girschick, Hermann, Peters Jochen, Michel Detlef, Streng Andrea, Sauerbrey Axel, Wirth, Stephan, Kuscher Ellen, Detlef Michel, Girschick Hermann, Kuscher, Ellen   +65 more
core   +2 more sources

Influenza A(H7N9) Pandemic Preparedness: Assessment of the Breadth of Heterologous Antibody Responses to Emerging Viruses from Multiple Pre-Pandemic Vaccines and Population Immunity

Vaccines, 2022
Influenza A(H7N9) viruses remain as a high pandemic threat. The continued evolution of the A(H7N9) viruses poses major challenges in pandemic preparedness strategies through vaccination.
Min Z. Levine, Crystal Holiday, Yaohui Bai, Weimin Zhong, Feng Liu, Stacie Jefferson, F. Liaini Gross, Wen-pin Tzeng, Louis Fries, Gale Smith, Philippe Boutet, Damien Friel, Bruce L. Innis, Corey P. Mallett, C. Todd Davis, David E. Wentworth, Ian A. York, James Stevens, Jacqueline M. Katz, Terrence Tumpey   +19 more
doaj   +1 more source