Results 31 to 40 of about 3,001 (154)

Adjuvanted influenza vaccines

Human Vaccines & Immunotherapeutics, 2018
In spite of current influenza vaccines being immunogenic, evolution of the influenza virus can reduce efficacy and so influenza remains a major threat to public health.
John S. Tregoning, Ryan F. Russell, Ekaterina Kinnear   +2 more
doaj   +1 more source

Designer Solid Self-Emulsifying Nanovaccines Enable Dual Modulation of Dendritic Cells and T Cells for Potent Antitumor Immunity. [PDF]

Adv Sci (Weinh)
A solid self‐emulsifying (SSE) platform is loaded with peptide antigens and CpG to form the SSE vaccine. An ApoE‐enriched corona promotes dendritic cell internalization, enabling antigen presentation and T cell activation. Squalene from the SSE also sensitizes T cells by promoting lipid raft formation.
Shen X, Fan S, He J, Luo L, Li J, Wu C, Yang K, Xia X, Kuai R.   +8 more
europepmc   +2 more sources

Superior antigen-specific CD4+T-cell response with AS03-adjuvantation of a trivalent influenza vaccine in a randomised trial of adults aged 65 and older [PDF]

, 2014
BACKGROUND: The effectiveness of trivalent influenza vaccines may be reduced in older versus younger adults because of age-related immunosenescence. The use of an adjuvant in such a vaccine is one strategy that may combat immunosenescence, potentially by
Caso, Covadonga, Béatrice Laupèze, Laupeze, Beatrice, Philippe Moris, Núñez López, Concepción, Innocent Nnadi Mbawuike, Claeys, Carine, Lidia Oostvogels, Caroline Hervé, José M Bayas, Concepción Núñez López, Couch, Robert B., Mbawuike, Innocent Nnadi, Carine Claeys, Mohamed El Idrissi, Bayas Rodríguez, José María, Covadonga Caso, El Idrissi, Mohamed, Moris, Philippe, Oostvogels, Lidia, Herve, Caroline, Robert B Couch   +21 more
core   +2 more sources

Influenza symptoms and their impact on elderly adults : randomised trial of AS03-adjuvanted or non-adjuvanted inactivated trivalent seasonal influenza vaccines [PDF]

, 2014
Background: Patient-reported outcomes (PROs) are particularly relevant in influenza vaccine trials in the elderly where reduction in symptom severity could prevent illness-related functional impairment. Objectives: To evaluate PROs in people aged 65years
Beran, Jiri, Gerrit A. van Essen, Xavier Duval, Ann R. Falsey, Jan Hendrik Richardus, Lidia Oostvogels, Martina Kovac, McNeil, Shelly, Geert Leroux‐Roels, Richardus, Jan Hendrik, Falsey, Ann R, Ruiz-Palacios, Guillermo, Osborne, Richard H, Leroux-Roels, Geert, Durand, Christelle, McElhaney, Janet E, Meral Esen, Innis, Bruce L, Oostvogels, Lidia, Odile Launay, Jeanne‐Marie Devaster, Guillermo Ruiz‐Palacios, Duval, Xavier, Esen, Meral, Gervais, Pierre, Pierre Gervais, Launay, Odile, Shelly McNeil, Feldman, Gregory, Richard H. Osborne, Mohammed Oujaa, van Essen, Gerrit A, Bruce L. Innis, Janet E. McElhaney, Christelle Durand, Oujaa, Mohammed, Kovac, Martina, Devaster, Jeanne-Marie, Jiri Beran, Gregory Feldman   +39 more
core   +1 more source

Immunopotentiation by Natural Extracts: Mechanisms and Applications in Influenza Vaccine Adjuvant Development. [PDF]

Food Sci Nutr
Natural Extracts as Candidate Influenza Vaccine Adjuvants. Seasonal influenza vaccines face limitations due to viral mutations and low efficacy in vulnerable populations. Traditional adjuvants often have safety or immune‐activation constraints, leading to increased interest in natural extracts from plants, marine organisms, and fungi.
Ho TL, Ko EJ.
europepmc   +2 more sources

Different Adjuvants Induce Common Innate Pathways That Are Associated with Enhanced Adaptive Responses against a Model Antigen in Humans

Frontiers in Immunology, 2017
To elucidate the role of innate responses in vaccine immunogenicity, we compared early responses to hepatitis B virus (HBV) surface antigen (HBsAg) combined with different Adjuvant Systems (AS) in healthy HBV-naïve adults, and included these parameters ...
Wivine Burny, Andrea Callegaro, Viviane Bechtold, Frédéric Clement, Sophie Delhaye, Laurence Fissette, Michel Janssens, Geert Leroux-Roels, Arnaud Marchant, Robert A. van den Berg, Nathalie Garçon, Robbert van der Most, Arnaud M. Didierlaurent, On Behalf of the ECR-002 Study Group, Viviane Bechtold, Wivine Burny, Andrea Callegaro, Isabelle Carletti, Frédéric Clement, Sophie Delhaye, Arnaud Didierlaurent, Meral Esen, Laurence Fissette, Julian Gabor, Nathalie Garçon, Edwige Haelterman, Caroline Hervé, Yves Horsmans, Michel Janssens, Peter Kremsner, Geert Leroux-Roels, Arnaud Marchant, Philippe Moris, Tino F Schwarz, Fernanda Tavares da Silva, Pascale Van Belle, Pierre Van Damme, Robert A. van den Berg, Robbert van der Most, Dirk Zuchner   +39 more
doaj   +1 more source

AS03-adjuvanted vaccine NK-cell gene responses correlated with serum IP-10 cytokine responses 3 days post-vaccination.

, 2017
Canonical correlation plots summarizing key correlation patterns between changes in serum cytokine/antibody responses and gene responses at day 3 in NK cells; (A) SV-AS03, (B) SV-PBS. See Fig 10legend for additional information.
Heather Hill (3666856), Allison Galassie (694630), Kathryn M. Edwards (534416), Leigh M. Howard (694627), Laura E. Gordy (353375), Sebastian Joyce (353377), Shawn E. Levy (694633), Tara M. Allos (694631), Xinnan Niu (694628), Nripesh Prasad (694629), Travis L. Jensen (3666853), Johannes B. Goll (495915), Andrew J. Link (366977), C. Buddy Creech (748289), Kristen L. Hoek (694625), Parimal Samir (694626)   +15 more
core   +1 more source

Investigating the effect of AS03 adjuvant on the plasma cell repertoire following pH1N1 influenza vaccination [PDF]

, 2016
Influenza pandemics require rapid deployment of effective vaccines for control. Adjuvants such as AS03 improve vaccine immunogenicity, but this mechanism is poorly understood.
Galson, J D, Trück, Johannes; https://orcid.org/, Kelly, D F, van der Most, R, Galson, J. D., Kelly, D. F., Trück, J., van der Most, R.   +7 more
core   +1 more source

AS03-adjuvanted vaccine gene responses in neutrophils, monocytes and dendritic cells correlated with serum IP-10 and MIP−1α serum cytokine responses 1 day post-vaccination.

, 2017
Canonical correlation plots summarizing key correlation patterns between changes in serum cytokine/antibody responses and gene responses at day 1 in (A,B) neutrophils (SV-AS03 and SV-PBS, respectively), (C) monocytes (SV-AS03), and (D) dendritic cells ...
Heather Hill (3666856), Allison Galassie (694630), Kathryn M. Edwards (534416), Leigh M. Howard (694627), Laura E. Gordy (353375), Sebastian Joyce (353377), Shawn E. Levy (694633), Tara M. Allos (694631), Xinnan Niu (694628), Nripesh Prasad (694629), Travis L. Jensen (3666853), Johannes B. Goll (495915), Andrew J. Link (366977), C. Buddy Creech (748289), Kristen L. Hoek (694625), Parimal Samir (694626)   +15 more
core   +1 more source

Robust induction of functional humoral response by a plant-derived Coronavirus-like particle vaccine candidate for COVID-19

npj Vaccines, 2023
Despite the success of existing COVID-19 vaccine platforms, the persistent limitations in global deployment of vaccines and waning immunity exhibited by many of the currently deployed vaccine platforms have led to perpetual outbreaks of SARS-CoV-2 ...
Paulina Kaplonek, Deniz Cizmeci, Jessica Shih-Lu Lee, Sally A. Shin, Stephanie Fischinger, Philipe Gobeil, Stéphane Pillet, Nathalie Charland, Brian J. Ward, Galit Alter   +9 more
doaj   +1 more source