Immunogenicity and safety of SARS-CoV-2 recombinant protein nanoparticle vaccine GBP510 adjuvanted with AS03: interim results of a randomised, active-controlled, observer-blinded, phase 3 trialResearch in context [PDF]
EClinicalMedicine, 2023 Summary: Background: GBP510 vaccine contains self-assembling, recombinant nanoparticles displaying SARS-CoV-2 spike receptor-binding domains. We report interim phase 3 immunogenicity results for GBP510 adjuvanted with AS03 (GBP510/AS03) compared with ...
Joon Young Song +60 more
doaj +3 more sources
The antibody landscapes following AS03 and MF59 adjuvanted H5N1 vaccination [PDF]
npj Vaccines, 2022 Current seasonal and pre-pandemic influenza vaccines induce short-lived predominantly strain-specific and limited heterosubtypic responses. To better understand how vaccine adjuvants AS03 and MF59 may provide improved antibody responses to vaccination ...
Johannes B. Goll +16 more
doaj +2 more sources
Neuronal Antibodies in Children with or without Narcolepsy following H1N1-AS03 Vaccination. [PDF]
PLoS ONE, 2015 Type 1 narcolepsy is caused by deficiency of hypothalamic orexin/hypocretin. An autoimmune basis is suspected, but no specific antibodies, either causative or as biomarkers, have been identified. However, the AS03 adjuvanted split virion H1N1 (H1N1-AS03)
Simon Thebault +9 more
doaj +2 more sources
Cell-Based Systems Biology Analysis of Human AS03-Adjuvanted H5N1 Avian Influenza Vaccine Responses: A Phase I Randomized Controlled Trial. [PDF]
PLoS ONE, 2017 BACKGROUNDVaccine development for influenza A/H5N1 is an important public health priority, but H5N1 vaccines are less immunogenic than seasonal influenza vaccines. Adjuvant System 03 (AS03) markedly enhances immune responses to H5N1 vaccine antigens, but
Leigh M Howard +15 more
doaj +2 more sources
An innate immune signature induced by AS01- or AS03-adjuvanted vaccines predicts the antibody response magnitude and quality consistently over time [PDF]
Frontiers in ImmunologyBackgroundAntibody-mediated protection can depend on mechanisms varying from neutralization to Fc-dependent innate immune-cell recruitment. Adjuvanted vaccine development relies on a holistic understanding of how adjuvants modulate the quantity/titer and
Setareh Tasdighian +6 more
doaj +3 more sources
AS03- and MF59-Adjuvanted Influenza Vaccines in Children [PDF]
Frontiers in Immunology, 2017 Influenza is a major cause of respiratory disease leading to hospitalization in young children. However, seasonal trivalent influenza vaccines (TIVs) have been shown to be ineffective and poorly immunogenic in this population.
Amanda L. Wilkins +9 more
doaj +3 more sources
Analysis of the dose-sparing effect of adjuvanted Sabin-inactivated poliovirus vaccine (sIPV)
Human Vaccines & Immunotherapeutics, 2018 Sabin-based inactivated poliovirus vaccine(sIPV) is gradually replacing live-attenuated oral polio vaccine(OPV). Sabin-inactivated poliovirus vaccine(sIPV) has played a vital role in reducing economic burden of poliomyelitis and maintaining appropriate ...
Zhuofan Li +7 more
doaj +2 more sources
Persistently high antibody responses after AS03-adjuvanted H1N1pdm09 vaccine: Dissecting the HA specific antibody response [PDF]
npj Vaccines, 2021 Current influenza vaccines have a suboptimal effectiveness. The introduction of a novel A/H1N1 influenza virus in 2009 (H1N1pdm09) provided a unique opportunity to study the humoral response to the AS03-adjuvanted H1N1pdm09 vaccine and repeated annual ...
Anders Madsen +4 more
doaj +2 more sources
EClinicalMedicine, 2023 Summary: Background: In a parallel-group, international, phase 3 study (ClinicalTrials.gov NCT04762680), we evaluated prototype (D614) and Beta (B.1.351) variant recombinant spike protein booster vaccines with AS03-adjuvant (CoV2 preS dTM-AS03). Methods:
Guy de Bruyn +157 more
doaj +2 more sources
Low Seroconversion after One Dose of AS03-Adjuvanted H1N1 Pandemic Influenza Vaccine in Solid-Organ Transplant Recipients [PDF]
Canadian Journal of Infectious Diseases and Medical Microbiology, 2013 BACKGROUND: Immunocompromised individuals are more susceptible to complications produced by influenza infection. As a result, solid-organ transplant (SOT) recipients were targeted as a priority group to receive AS03-adjuvanted H1N1 influenza vaccine ...
Mariangela R Resende +6 more
doaj +2 more sources