Results 21 to 30 of about 3,001 (154)

Narcolepsy, autoimmunity, and influenza A H1N1 vaccination [PDF]

Encephalitis, 2021
Narcolepsy is a rare neurological disorder characterized by excessive daytime sleepiness (EDS) with or without cataplexy. A main pathophysiology of narcolepsy is hypocretin deficiency in the central nervous system resulting from a selective loss of ...
Jun-Sang Sunwoo
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AS03-adjuvanted H7N9 inactivated split virion vaccines induce cross-reactive and protective responses in ferrets

npj Vaccines, 2021
Human infections with avian H7N9 subtype influenza viruses are a major public health concern and vaccines against H7N9 are urgently needed for pandemic preparedness.
Daniel Stadlbauer, Leon de Waal, Edith Beaulieu, Shirin Strohmeier, Edwin J. B. Veldhuis Kroeze, Philippe Boutet, Albert D. M. E. Osterhaus, Florian Krammer, Bruce L. Innis, Raffael Nachbagauer, Koert J. Stittelaar, Corey P. Mallett   +11 more
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PHASE 3 STUDY OF SAFETY AND IMMUNOGENICITY OF GBP510 VACCINE ADJUVANTED WITH AS03 IN ADULTS

International Journal of Infectious Diseases, 2023
Intro: GBP510 contains the self-assembling recombinant nanoparticle displaying SARS‐CoV-2 Spike protein receptor binding domain and is adjuvanted with AS03.
J.Y. Song, W.S. Choi, H.J. Cheong, H. Kim   +3 more
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Immunogenicity and protective efficacy of GBP510/AS03 vaccine against SARS-CoV-2 delta challenge in rhesus macaques

npj Vaccines, 2023
Despite the availability of several effective SARS-CoV-2 vaccines, additional vaccines will be required for optimal global vaccination. In this study, we investigate the immunogenicity and protective efficacy of the GBP510 protein subunit vaccine ...
Catherine Jacob-Dolan, Jingyou Yu, Katherine McMahan, Victoria Giffin, Abishek Chandrashekar, Amanda J. Martinot, Tochi Anioke, Olivia C. Powers, Kevin Hall, David Hope, Jessica Miller, Nichole P. Hachmann, Benjamin Chung, Sarah Gardner, Daniel Sellers, Julia Barrett, Mark G. Lewis, Hanne Andersen, Harry Kleanthous, Ki-Woen Seo, Su Jeen Lee, Yong Wook Park, Hun Kim, Dan H. Barouch   +23 more
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Safety and immunogenicity of a SARS-CoV-2 recombinant protein nanoparticle vaccine (GBP510) adjuvanted with AS03: A randomised, placebo-controlled, observer-blinded phase 1/2 trial

EClinicalMedicine, 2022
Summary: Background: Vaccination has helped to mitigate the COVID-19 pandemic. Ten traditional and novel vaccines have been listed by the World Health Organization for emergency use.
Joon Young Song, Won Suk Choi, Jung Yeon Heo, Jin Soo Lee, Dong Sik Jung, Shin-Woo Kim, Kyung-Hwa Park, Joong Sik Eom, Su Jin Jeong, Jacob Lee, Ki Tae Kwon, Hee Jung Choi, Jang Wook Sohn, Young Keun Kim, Ji Yun Noh, Woo Joo Kim, François Roman, Maria Angeles Ceregido, Francesca Solmi, Agathe Philippot, Alexandra C. Walls, Lauren Carter, David Veesler, Neil P. King, Hun Kim, Ji Hwa Ryu, Su Jeen Lee, Yong Wook Park, Ho Keun Park, Hee Jin Cheong   +29 more
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Adjuvantation of Influenza Vaccines to Induce Cross-Protective Immunity

Vaccines, 2021
Influenza poses a huge threat to global public health. Influenza vaccines are the most effective and cost-effective means to control influenza. Current influenza vaccines mainly induce neutralizing antibodies against highly variable globular head of ...
Zhuofan Li, Yiwen Zhao, Yibo Li, Xinyuan Chen   +3 more
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Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization in macaques and protection in hamsters

Communications Medicine, 2023
Background Since the beginning of the COVID-19 pandemic, several variants of concern (VOC) have emerged for which there is evidence of an increase in transmissibility, more severe disease, and/or reduced vaccine effectiveness.
Catherine Berry, Vincent Pavot, Natalie G. Anosova, Michael Kishko, Lu Li, Tim Tibbitts, Alice Raillard, Sylviane Gautheron, Sheila Cummings, Dinesh S. Bangari, Swagata Kar, Caroline Atyeo, Yixiang Deng, Galit Alter, Cindy Gutzeit, Marguerite Koutsoukos, Roman M. Chicz, Valerie Lecouturier   +17 more
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Comparison of different adjuvants for immune efficacy of recombinant PKF protein of Acinetobacter baumannii

陆军军医大学学报, 2023
Objective To compare the immune effects of recombinant PKF protein of Acinetobacter baumannii with different immune modes and different adjuvants. Methods After recombinant PKF protein was obtained by plasmid expression and purification, the protein was ...
ZHANG Shanshan, ZHANG Shanshan, LI Guocheng, FENG Rang, XUE Ruoyi   +4 more
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Systems serology-based comparison of antibody effector functions induced by adjuvanted vaccines to guide vaccine design

npj Vaccines, 2023
The mechanisms by which antibodies confer protection vary across vaccines, ranging from simple neutralization to functions requiring innate immune recruitment via Fc-dependent mechanisms.
Carolin Loos, Margherita Coccia, Arnaud M. Didierlaurent, Ahmed Essaghir, Jonathan K. Fallon, Douglas Lauffenburger, Corinne Luedemann, Ashlin Michell, Robbert van der Most, Alex Lee Zhu, Galit Alter, Wivine Burny   +11 more
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A Self-Emulsified Adjuvant System Containing the Immune Potentiator Alpha Tocopherol Induces Higher Neutralizing Antibody Responses than a Squalene-Only Emulsion When Evaluated with a Recombinant Cytomegalovirus (CMV) Pentamer Antigen in Mice

Pharmaceutics, 2023
The development of new vaccine adjuvants represents a key approach to improvingi the immune responses to recombinant vaccine antigens. Emulsion adjuvants, such as AS03 and MF59, in combination with influenza vaccines, have allowed antigen dose sparing ...
Rushit N. Lodaya, Amey P. Kanitkar, Asma Ashraf, Douty Bamba, Mansoor M. Amiji, Derek T. O’Hagan   +5 more
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