Comparison of the adjuvant effect of AS01, AS03 and alum on the immune response to GMP-grade H5N1 antigen in guinea pigs [PDF]
Scientific ReportsAdjuvants function as an enhancer and activator of the immune response and can be of pivotal importance for the efficacy of vaccines. AS01, which is a liposome formulation spiked with the saponin derivate QS-21 and the detoxified lipopolysaccharide MPL-A,
Emmelie Eckhardt +7 more
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A Rabies Virus Glycoprotein Subunit Vaccine Produced in Pichia pastoris Induces Neutralizing Antibodies in Mice [PDF]
VaccinesBackground: Rabies is a highly fatal zoonotic disease that causes approximately 59,000 human deaths worldwide each year. Current inactivated rabies vaccines require multiple doses and are associated with high costs.
Ye Yang +11 more
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Human Vaccines and Immunotherapeutics, 2017 We investigated the long-term immune profiles of dose-sparing, AS03-adjuvanted vaccines compared to a traditional high-dose, unadjuvated influenza vaccine formulation.
Corey P Mallett +2 more
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Human Vaccines and Immunotherapeutics, 2017 An increased risk of narcolepsy following administration of an AS03-adjuvanted A(H1N1)pdm09 pandemic influenza vaccine (Pandemrix™) was described in children and adolescents in certain European countries.
Eric Destexhe +2 more
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Transcriptomic and proteomic signatures following AS03-adjuvanted Influenza A/H7N9 vaccine [PDF]
Frontiers in ImmunologyIntroductionVaccines targeting avian influenza virus A/H7N9 are poorly immunogenic. While the immune responses can be improved with oil-in-water emulsion adjuvants such as Adjuvant System 03 (AS03), the cellular mechanisms underpinning the adjuvant ...
C. Buddy Creech +8 more
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AS03-adjuvanted H5N1 vaccine enhances immune response by modulating NR4A1, SDC1, ID3 genes, and reducing cortisol [PDF]
Human Vaccines & ImmunotherapeuticsThe AS03-adjuvanted H5N1 influenza vaccine induces significantly higher immune responses compared to the non-adjuvanted H5N1 vaccine. However, the immunological mechanisms underlying this enhancement remain unclear. We aimed to identify the key genes and
Lairun Jin, Jingxin Li, Fengcai Zhu
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Adjuvanted influenza vaccination increases pre-existing H5N1 cross-reactive antibodies [PDF]
Nature CommunicationsHighly pathogenic H5N1 avian influenza viruses of clade 2.3.4.4b cause sporadic human infections and currently raise concerns about a new influenza pandemic.
Mariana Alcocer Bonifaz +4 more
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Novel nanoemulsion adjuvant stabilized by TPGS possesses equivalent physicochemical properties, Turbiscan stability, and adjuvanticity to AS03 for eliciting robust immunogenicity of subunit vaccines in mice [PDF]
Human Vaccines & ImmunotherapeuticsEmulsion-based antigen delivery systems have emerged as a novel approach to enhance the effectiveness of subunit vaccines. This study presents the development of a newly formulated oil-in-water (o/w) nanoemulsion adjuvant (NEA) composed of squalene oil ...
Quanyi Yin, Shuoyao Song, Zhilei Liu
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Distinct effects of adjuvants on B cell responses to protein or polysaccharide antigens contained in glycoconjugate vaccines [PDF]
Frontiers in ImmunologyBackgroundProtein-polysaccharide conjugate vaccines rely on the induction of T-cell-dependent responses that support germinal center (GC) reactions to potentiate the expansion of antigen-specific memory B-cell (MBC) populations and high-avidity antibody ...
Sonia Budroni +13 more
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Modular assembly and immunological evaluation of a promising bioconjugate nanovaccine against Klebsiella pneumoniae O2 serotype [PDF]
npj VaccinesThe antimicrobial-resistant (AMR) Klebsiella pneumoniae (Kp) poses an enormous threat to human health, with O2 serotypes accounting for up to 35–59% of infections. Although the O-polysaccharide (OPS) of the Kp O2 serotype can be used as an antigen target
Peng Sun +11 more
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