Results 61 to 70 of about 5,708 (209)

Finding Cycles and Trees in Sublinear Time [PDF]

, 2011
We present sublinear-time (randomized) algorithms for finding simple cycles of length at least $k\geq 3$ and tree-minors in bounded-degree graphs. The complexity of these algorithms is related to the distance of the graph from being $C_k$-minor-free ...
Alon, Benjamini, Bollobás, Fischer, Friedman, Goldreich, Goldreich, Goldreich, Goldreich, Goldreich, Hassidim, Kaufman, Kawarabayashi, Kuratowski, Parnas, Reznik, Robertson, Robertson, Ron, Ron, Wagner   +20 more
core   +4 more sources

Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice

npj Vaccines, 2022
Adjuvants enhance the magnitude and the durability of the immune response to vaccines. However, there is a paucity of comparative studies on the nature of the immune responses stimulated by leading adjuvant candidates.
Lilit Grigoryan, Audrey Lee, Alexandra C. Walls, Lilin Lai, Benjamin Franco, Prabhu S. Arunachalam, Yupeng Feng, Wei Luo, Abigail Vanderheiden, Katharine Floyd, Samuel Wrenn, Deleah Pettie, Marcos C. Miranda, Elizabeth Kepl, Rashmi Ravichandran, Claire Sydeman, Natalie Brunette, Michael Murphy, Brooke Fiala, Lauren Carter, Robert L. Coffman, David Novack, Harry Kleanthous, Derek T. O’Hagan, Robbert van der Most, Jason S. McLellan, Mehul Suthar, David Veesler, Neil P. King, Bali Pulendran   +29 more
doaj   +1 more source

AS03-adjuvanted, very-low-dose influenza vaccines induce distinctive immune responses compared to unadjuvanted high-dose vaccines in BALB/c mice

Frontiers in Immunology, 2015
During the 2009-2010 influenza pandemic, an adjuvanted, dose-sparing vaccine was recommended for most Canadians. We hypothesize that differences exist in the responses to AS03-adjuvanted, low antigen (Ag) dose versus unadjuvanted, full-dose vaccines.
Karen K Yam, Jyotsana eGupta, Kaitlin eWinter, Elizabeth eAllen, Angela eBrewer, Édith eBeaulieu, Corey P Mallett, David S Burt, Brian J Ward, Brian J Ward   +9 more
doaj   +1 more source

Whole‐blood cytokine secretion assay as a high‐throughput alternative for assessing the cell‐mediated immunity profile after two doses of an adjuvanted SARS‐CoV‐2 recombinant protein vaccine candidate

Clinical & Translational Immunology, 2022
Objectives We previously described the Phase I‐II evaluation of SARS‐CoV‐2 recombinant protein candidate vaccine, CoV2‐PreS‐dTM, with AF03‐ or AS03‐adjuvant systems (ClinicalTrials.gov, NCT04537208).
Stephen C De Rosa, Kristen W Cohen, Matthew Bonaparte, Bo Fu, Sanjay Garg, Catherine Gerard, Paul A Goepfert, Ying Huang, Daniel Larocque, M. Juliana McElrath, Daryl Morris, Robbert Van der Most, Guy deBruyn, Anke Pagnon   +13 more
doaj   +1 more source

Projective-injective modules, Serre functors and symmetric algebras [PDF]

, 2005
We describe Serre functors for (generalisations of) the category O associated with a semi-simple complex Lie algebra. In our approach, projective-injective modules play an important role.
Mazorchuk, Volodymyr, Stroppel, Catharina   +1 more
core   +2 more sources

Phase I, randomized, observer-blind, placebo-controlled studies to evaluate the safety, reactogenicity and immunogenicity of an investigational non-typeable Haemophilus influenzae (NTHi) protein vaccine in adults [PDF]

, 2016
Background: Non-typeable Haemophilus influenzae (NTHi) is a major cause of various respiratory diseases. The development of an effective vaccine against NTHi mandates new approaches beyond conjugated vaccines as this opportunistic bacterium is non ...
Aris, Emmanuel, Caubet, Magalie, Devaster, Jeanne-Marie, Haazen, Wouter, Leroux-Roels, Geert, Peeters, Mathieu, Shakib, Sepehr, Van Damme, Pierre   +7 more
core   +2 more sources

Identification of Mannose‐Capped‐Arabinomannan 101‐mer as a Potential Influenza Virus Vaccine Adjuvant

Advanced Science, EarlyView.
Well‐defined and synthetic mannose‐capped arabinomannan 101‐mer from Mycobacterium tuberculosis cell wall was identified as a potent influenza vaccine adjuvant, boosting the antibody response, realizing full protection and showing excellent safety. ABSTRACT Many natural bacterial components as adjuvants can activate the host immune system, but the ...
Yu‐Fang Zhang, Ruihong Xu, Jia Luo, Yuxin Ma, Guozhi Xiao, Ye Liu   +5 more
wiley   +1 more source

Comparison of adverse events following immunization with pandemic influenza A (H1N1)pdm09 vaccine with or without adjuvant among health professionals in Rio de Janeiro, Brazil

Memorias do Instituto Oswaldo Cruz, 2012
A vaccination campaign against pandemic influenza A (H1N1)pdm09 was held in Brazil in March 2010, using two types of monovalent split virus vaccines: an AS03-adjuvanted vaccine and a non-adjuvanted vaccine.
José Cerbino-Neto, Ananza Tainá da Silva Santos, Maria Isabel Fragoso da Silveira Gouvea, Renata Saraiva Pedro, Grazielle Viana Ramos, Lusiele Guaraldo, Guilherme Loureiro Werneck   +6 more
doaj   +1 more source

Efficacy and Safety of a Plant-Based Virus-Like Particle Vaccine for COVID-19 Adjuvanted with AS03

medRxiv, 2022
Background: Several COVID-19 vaccines are currently being deployed but supply constraints, concerns over durability of immune responses, solidifying vaccine hesitancy/resistance and vaccine efficacy in the face of emerging variants mean that new vaccines
K. Hager, G. P. Marc, P. Gobeil, R. Diaz, G. Heizer, C. Llapur, A. Makarkov, E. Vasconcellos, S. Pillet, F. Riera, K. Bhutada, P. Wolff, G. Wallace, H. Aazami, C. Jones, F. Polack, J. Atkins, I. Boulay, J. Dhaliwall, N. Charland, M. Couture, J. Jiang-Wright, N. Landry, S. Lapointe, A. Lorin, A. Mahmood, L. Moulton, E. Pahmer, J. Parent, P. Saxena, A. Séguin, L. Tran, T. Breuer, M. Ceregido, M. Koutsoukos, F. Roman, J. Namba, Marc‐André D'Aoust, S. Trépanier, Y. Kimura, The CoVLP Study Team, B. Ward   +41 more
semanticscholar   +1 more source

A Prussian Blue Nanozyme‐Adjuvanted Vaccine Presenting Phosphocholine Antigens for Induction of Immunotolerance in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study developed a novel nano‐vaccine (Ferritin‐PC@PBNZs) comprising a ferritin‐based scaffold for the multivalent display of phosphorylcholine (PC) antigens, integrated with Prussian blue nanozymes (PBNZs) as a potent adjuvant. By leveraging the ferritin carrier for high‐density and ordered antigen display, the nano‐vaccine significantly augments ...
Jingyi Sheng, Yubo Huang, Xinyue Li, Yin Liu, Yuehuang Wu, Yuxin Zhang, Ning Gu   +6 more
wiley   +1 more source