Results 61 to 70 of about 15,022,634 (265)

Association between oral 5-ASA adherence and health care utilization and costs among patients with active ulcerative colitis

BMC Gastroenterology, 2012
Background Observational cohort study to assess the association between adherence to oral 5-aminosalicylates (5-ASAs) and all-cause costs and health care utilization among patients with active ulcerative colitis (UC) in the United States.
Mitra Debanjali, Hodgkins Paul, Yen Linnette, Davis Keith L, Cohen Russell D   +4 more
doaj   +1 more source

Inflammatory Bowel Diseases and Coexisting Spondyloarthritis: A Neglected and too Often Under-Reported Association by Radiologists. A Multicenter Study by Italian Research Group of Imaging in Rheumatology

Gastroenterology Insights, 2020
Purpose: The purpose of this study was to evaluate the prevalence and the underreporting rate of sacroiliitis (SI) in a large cohort of patients with biopsy-proved Crohn’s disease (CD) who underwent magnetic resonance enterography (MRE) or computed ...
Maria Antonietta Mazzei, Francesco Gentili, Susanna Guerrini, Nunzia Di Meglio, Giuseppe Lo Re, Marina Carotti, Francesca Interlicchia, Alfonso Reginelli, Antonio Barile, Giulia Sadotti, Ubaldo Plastina Romeo, Ernesto La Paglia, Nicola Maggialetti, Rita Lo Scalzo, Alessia Vinci, Giuseppe Capodieci, Giovanna Vacca, Federico Bruno, Luca Cantarini, Bruno Frediani, Antonio Marchesoni, Andrea Giovagnoni, Luca Volterrani, Luca Brunese   +23 more
doaj   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Effect of Intravenous Golimumab on Fatigue and the Relationship with Clinical Response in Adults with Active Ankylosing Spondylitis in the Phase 3 GO-ALIVE Study

Rheumatology and Therapy, 2023
Introduction We studied the effect of intravenous (IV)-golimumab on fatigue and the association of fatigue improvement with clinical response post hoc in adults with active ankylosing spondylitis (AS) in the GO-ALIVE trial.
Atul Deodhar, Natalie J. Shiff, Cinty Gong, Eric K. H. Chan, Elizabeth C. Hsia, Kim Hung Lo, Alianu Akawung, Lilianne Kim, Stephen Xu, John D. Reveille   +9 more
doaj   +1 more source

Nanoscale Confinement Enhances Ultrafast Demagnetization

Advanced Science, EarlyView.
Next generation spintronics may depend on successfully combining femtosecond spin dynamics with nanoscale device miniaturization. We address this by systematically studying the effect of nanoscale confinement on the femtosecond demagnetization of Iron. By combining ultrafast experiments sensitive to spins, charge carriers, and phonons, we uncover a nm ...
Yoav William Windsor, Tobias Lojewski, Moumita Kundu, Klaus Sokolowski‐Tinten, Nico Rothenbach, Andrea Eschenlohr, Markus Ernst Gruner, Katharina Ollefs, Carolin Schmitz‐Antoniak, Soma Salamon, Daniela Zahn, Laurenz Rettig, Christian Schüßler‐Langeheine, Niko Pontius, Renkai Li, Mianzhen Mo, Suji Park, Xiaoshe Shen, Stephen Weathersby, Xijie Wang, Rossitza Pentcheva, Heiko Wende, Ulrich Nowak, Uwe Bovensiepen   +23 more
wiley   +1 more source

The life and health challenges of young Malaysian couples: results from a stakeholder consensus and engagement study to support non-communicable disease prevention [PDF]

, 2014
BACKGROUND: Malaysia faces burgeoning obesity and diabetes epidemics with a 250% and 88% increase respectively between 1996 and 2006. Identifying the health challenges of young adults in Malaysia, who constitute 27.5 % of the population, is critical for ...
SA Norris, H Anuar, Cheah, J., Norris, S., Matzen, P., JCH Cheah, Anuar, H., Hanson, Mark A., M Hanson, BB Jensen, P Matzen, Jensen, B.   +11 more
core   +1 more source

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Advanced Science, EarlyView.
After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan   +9 more
wiley   +1 more source

The status and correlation factors of fatigue in patients with ankylosing spondylitis (FACIT-F): a cross-sectional study based on the Chinese population

BMC Rheumatology
Objective To analyze the status and correlation factors of fatigue in patients with ankylosing spondylitis (AS), and provide a reference for improving the fatigue status of patients with AS.
Tiantian Sun, Kun Yang, Yuening Chen, Zhaoyang Geng, Xinning Qu, Qing Yu, Hongxiao Liu   +6 more
doaj   +1 more source

Discriminating capacity of the ASAS health index in patients with axial spondyloarthritis treated with ixekizumab

Seminars in Arthritis and Rheumatism
To test the discriminating capacity of different thresholds of the Assessment of SpondyloArthritis international Society Health Index (ASAS HI) in placebo-controlled trials of patients with axial spondyloarthritis (axSpA), including radiographic (r-axSpA) and non-radiographic (nr-axSpA) subtypes.The discriminating capacities of absolute (≥2.0-≥4.0 ...
Uta Kiltz, Anna Moltó, Désirée van der Heijde, Louis Bessette, Annelies Boonen, Rebecca Bolce, Christophe Sapin, Theresa Hunter Gibble, Boris Janos, Andris Kronbergs, Khai Jing Ng, Jürgen Braun   +11 more
openaire   +3 more sources

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source