Results 51 to 60 of about 32,132 (230)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

H2O2 Signature and Innate Antioxidative Profile Make the Difference Between Sensitivity and Tolerance to Salt in Rice Cells [PDF]

, 2018
Salt tolerance is a complex trait that varies between and within species. H2O2 profiles as well as antioxidative systems have been investigated in the cultured cells of rice obtained from Italian rice varieties with different salt tolerance.
Barizza, Elisabetta, Beatrice Ronci, Maria, De Gara, Laura, Formentin, Elide, Ijaz, Bushra, LO SCHIAVO, Fiorella, Locato, Vittoria, Stevanato, Piergiorgio, Sudiro, Cristina, Zottini, Michela   +9 more
core   +2 more sources

Suppressor of gamma response 1 modulates the DNA damage response and oxidative stress response in leaves of cadmium-exposed Arabidopsis thaliana [PDF]

, 2020
Cadmium (Cd) exposure causes an oxidative challenge and inhibits cell cycle progression, ultimately impacting plant growth. Stress-induced effects on the cell cycle are often a consequence of activation of the DNA damage response (DDR).
Cuypers, Ann, De Veylder, Lieven, Eekhout, Thomas, Hendrix, Sophie, Horemans, Nele, Huybrechts, Michiel, Iven, Verena, Keunen, Els, Pecqueur, Ingeborg, Vangronsveld, Jaco   +9 more
core   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Characterization of the antioxidant system during the vegetative development of pea plants

Biologia Plantarum, 2010
The antioxidative system was studied during the development of pea plants. The reduced glutathione (GSH) content was higher in shoots than in roots, but a greater redox state of glutathione existed in roots compared with shoots, at least after 7 d of ...
P. Díaz-Vivancos, G. Barba-Espín, M. J. Clemente-Moreno, J. A. Hernández   +3 more
doaj   +1 more source

Ascorbate-mediated regulation of growth, photoprotection, and photoinhibition in Arabidopsis thaliana. [PDF]

, 2018
The requirements for ascorbate for growth and photosynthesis were assessed under low (LL; 250 µmol m-2 s-1) or high (HL; 1600 µmol m-2 s-1) irradiance in wild-type Arabidopsis thaliana and two ascorbate synthesis mutants (vtc2-1 and vtc2-4) that have 30%
Alexander V Ruban, Alexandra J Townsend, Aller, Aro, Asada, Awad, Baier, Barbara Karpinska, Bartoli, Bartoli, Bashandy, Bratt, Brwa Rasool, Christine H Foyer, Cohu, Conklin, de Simone, de Simone, Demmig-Adams, Dowdle, Dutilleul, Foyer, Foyer, Foyer, Foyer, Foyer, Gallie, Giacomelli, Greenberg, Guo, Heber, Heyneke, Horling, Jahns, Jahns, Kangasjärvi, Karpinska, Karpinska, Kerchev, Kiddle, Kromdijk, Lichtenthaler, Lim, Mano, Maruta, Meyer, Miyaji, Munné-Bosch, Müller-Moulé, Müller-Moulé, Neff, Noctor, Nurhayati Razak, Osmond, Page, Pastori, Pavet, Pignocchi, Powles, Queval, Rouhier, Ruban, Ruban, Sarah Alomrani, Shaikhali, Smirnoff, Smirnoff, Tamaoki, Taylor, Tedone, Tyystjärvi, Tyystjärvi, Tóth, Vanderauwera, Wang, Ware, Wheeler, William Plumb, Yabuta, Yin, Zechmann, Zhang, Zhang   +82 more
core   +2 more sources

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

Advanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou   +5 more
wiley   +1 more source

Foliar-Applied Glutathione Mitigates Cadmium-Induced Oxidative Stress by Modulating Antioxidant-Scavenging, Redox-Regulating, and Hormone-Balancing Systems in Brassica napus

Frontiers in Plant Science, 2021
The antioxidant glutathione (GSH) mitigates adverse physio-metabolic effects and defends against abiotic types of stress, such as cadmium (Cd) stress. However, its function and role in resisting Cd phytotoxicity by leveraging plant antioxidant-scavenging,
Ha-il Jung, Tae-Gu Lee, Jinwook Lee, Mi-Jin Chae, Eun-Jin Lee, Myung-Sook Kim, Goo-Bok Jung, Amoakwah Emmanuel, Amoakwah Emmanuel, Sangho Jeon, Bok-Rye Lee   +10 more
doaj   +1 more source

Metarhizium anisopliaeMitigates the Phytotoxicity of Lead and Nanoplastics on Rice by Modifying Physiological, Transcriptomic, Metabolomic Activities, and Soil Microbiome

Advanced Science, EarlyView.
Metarhizium anisopliae alleviates the phytotoxic effects of polyethylene nanoplastics (NP) and lead (Pb) in rice by decreasing Pb uptake, restoring antioxidant and hormonal equilibrium, and promoting growth. Additionally, the fungus modifies the rhizosphere microbiota, enhancing both contaminant tolerance and plant growth, thereby effectively ...
Jing Peng, Qi Yan, Muhammad Umair Hassan, Muhammad Imran, Fasih Ullah Haider, Jianfeng Liang, Xingmin Wang, Shaukat Ali   +7 more
wiley   +1 more source

Fulvic Acid Enhances Oat Growth and Grain Yield Under Drought Deficit by Regulating Ascorbate–Glutathione Cycle, Chlorophyll Synthesis, and Carbon–Assimilation Ability

Agronomy
Drought deficit inhibits oat growth and yield. Fulvic acid (FA) can enhance plant stress tolerance, but its effects on regulating the ascorbate–glutathione cycle, chlorophyll synthesis, and carbon–assimilation ability remain unclear.
Shanshan Zhu, Junzhen Mi, Baoping Zhao, Yongjian Kang, Mengxin Wang, Jinghui Liu   +5 more
doaj   +1 more source