Results 51 to 60 of about 1,183 (130)

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, Volume 58, Issue 10, October 2025.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source

ASIC2 and 3 contribute to the composition of ASICs in murine sympathetic cardiac afferents

The FASEB Journal, 2007
Acid‐Sensing Ion Channels (ASICs) are proton‐gated channels that are highly expressed in cardiac afferents. 4 genes encode ASICs; our objective here was to determine the subunit composition in cardiac afferents. Whole‐cell patch‐clamp experiments were performed on cultured upper thoracic (C8‐T3) dorsal root ganglia (DRG) neurons from wild type (WT) or ...
Tomonori Hattori, Christopher J. Benson
openaire   +1 more source

Calcium regulation of muscle spindle mechanosensory afferent function

Experimental Physiology, Volume 110, Issue 10, Page 1457-1472, October 1, 2025.
Abstract Extracellular calcium is crucial for the normal function of muscle spindle sensory afferents. They express multiple calcium buffering proteins. Extracellular calcium is essential for recycling of synaptic‐like vesicles (SLVs) in the terminals and for the stretch‐evoked inward calcium current of the receptor potential.
Anna Simon, Richard A. Lofthouse, Philip Miti, Claudiu V. Giuraniuc, Robert W. Banks, Guy S. Bewick   +5 more
wiley   +1 more source

Transcriptomic signatures of host immune responses in aphthous ulcers, the earliest lesions of Crohn's disease, suggest that bacterial uptake, rather than global dysbiosis, is the initiating factor

Immunology &Cell Biology, Volume 103, Issue 5, Page 473-484, May‐June 2025.
To identify mechanisms underlying the earliest stages of disease initiation, we compared gene expression in aphthous ulcers, Peyer's patches, inflamed and endoscopically normal mucosa from patients and controls using total RNA‐seq. The signatures obtained suggest epithelial stress, plasma cell activation, monocyte activation and interferon‐γ signaling ...
Phillip J Whiley, Ojas V A Dixit, Mukta Das Gupta, Hardip Patel, Guoyan Zhao, Susan J Connor, Kim M Summers, David A Hume, Paul Pavli, Claire L O'Brien   +9 more
wiley   +1 more source

Neurocardiology: translational advancements and potential

The Journal of Physiology, Volume 603, Issue 7, Page 1729-1779, 31 March 2025.
Abstract figure legend Afferent signalling pathways of the autonomic nervous system and their efferent targets in the heart, kidneys and vasculature. Abstract In our original white paper published in the The Journal of Physiology in 2016, we set out our knowledge of the structural and functional organization of cardiac autonomic control, how it ...
N. Herring, O. A. Ajijola, R. D. Foreman, A. V. Gourine, A. L. Green, J. Osborn, D. J. Paterson, J. F. R. Paton, C. M. Ripplinger, C. Smith, T. L. Vrabec, H. J. Wang, I. H. Zucker, J. L. Ardell   +13 more
wiley   +1 more source

Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing

The Journal of Physiology, 2004
Mechanosensitive cation channels are thought to be crucial for different aspects of mechanoperception, such as hearing and touch sensation. In the nematode C. elegans, the degenerins MEC‐4 and MEC‐10 are involved in mechanosensation and were proposed to form mechanosensitive cation channels.
Roza, Carolina, Puel, Jean-Luc, Kress, Michaela, Baron, Anne, Diochot, Sylvie, Lazdunski, Michel, Waldmann, Rainer   +6 more
openaire   +3 more sources

Pangenome and genome variation analyses of pigs unveil genomic facets for their adaptation and agronomic characteristics

iMeta, Volume 3, Issue 6, December 2024.
The development of a comprehensive pig graph pangenome assembly encompassing 27 genomes represents the most extensive collection of pig genomic data to date. Analysis of this pangenome reveals the critical role of structural variations in driving adaptation and defining breed‐specific traits.
Dong Li, Yulong Wang, Tiantian Yuan, Minghao Cao, Yulin He, Lin Zhang, Xiang Li, Yifan Jiang, Ke Li, Jingchun Sun, Guangquan Lv, Guosheng Su, Qishan Wang, Yuchun Pan, Xinjian Li, Yu Jiang, Gongshe Yang, Martien A. M. Groenen, Martijn F. L. Derks, Rongrong Ding, Xiangdong Ding, Taiyong Yu   +21 more
wiley   +1 more source

Contrasting Autonomic and Cardiovascular Phenotypes in ASIC1a and ASIC2 deficient mice

The FASEB Journal, 2008
Members of the acid‐sensing ion channel (ASIC) family are differentially expressed in subpopulations of sensory and central neurons and have been implicated in a variety of neuronal functions. We recently demonstrated that mice deficient in ASIC2, a subunit implicated in mechanotransduction, exhibit baroreflex and autonomic ...
Rasna Sabharwal, John A Wemmie, Francois M Abboud, Mark W Chapleau   +3 more
openaire   +1 more source

pH: A major player in degenerative intervertebral disks

JOR SPINE, Volume 7, Issue 4, December 2024.
Chronic lower back pain, often caused by degenerative disk disease (DDD), is a major global health issue with significant socioeconomic impact. Although the relationship between disk degeneration and pain is well‐established, the role of low pH in contributing to pain has been underexplored.
Matthew A. R. Trone, Joshua D. Stover, Alejandro Almarza, Robert D. Bowles   +3 more
wiley   +1 more source

Genome-wide associations with longevity and reproductive traits in U.S. rangeland ewes

Frontiers in Genetics
Introduction: Improving ewe longevity is an important breeding and management goal, as death loss and early culling of mature ewes are economic burdens in the sheep industry.
Jamin A. Smitchger, J. Bret Taylor, Michelle R. Mousel, Daniel Schaub, Jacob W. Thorne, Jacob W. Thorne, Gabrielle M. Becker, Brenda M. Murdoch   +7 more
doaj   +1 more source