Results 31 to 40 of about 1,183 (130)

A study of the expression of small conductance calcium-activated potassium channels (SK1-3) in sensory endings of muscle spindles and lanceolate endings of hair follicles in the rat. [PDF]

PLoS ONE, 2014
Processes underlying mechanotransduction and its regulation are poorly understood. Inhibitors of Ca2+-activated K+ channels cause a dramatic increase in afferent output from stretched muscle spindles.
Fiona Shenton, Guy S Bewick, Robert W Banks   +2 more
doaj   +1 more source

Immunohistochemical Detection of the Putative Mechanoproteins ASIC2 and TRPV4 in Avian Herbst Sensory Corpuscles [PDF]

The Anatomical Record, 2012
AbstractThe avian Herbst corpuscles are the equivalent of the Pacinian corpuscles in mammals, and detect vibration and the movement of joints and feathers. Therefore, they can be regarded as rapidly adapting low‐threshold mechanoreceptors. In recent years, it has been establish that some ion channels are involved in mechanosensation and are present in ...
Cabo R, Gálvez A, LAURA', Rosaria, San José I, Pastor JF, López Muñiz A, García Suárez O, Vega JA   +7 more
openaire   +2 more sources

The Isolated Thumb Domain of Acid‐Sensing Ion Channels Forms a Minimal Folding Unit Enabling Ligand Binding Studies

Angewandte Chemie, Volume 138, Issue 19, 4 May 2026.
An independently folded thumb domain from acid‐sensing ion channels (ASICs) preserves ligand‐binding and proton‐sensing properties. NMR‐based interaction and pKa analyses uncover how endogenous and exogenous peptides modulate ASICs, providing a simplified model for rational drug discovery targeting proton‐gated ion channels.
Biswa P. Mishra, Ben Cristofori‐Armstrong, Elena Budusan, Mimi Golder, Neville J. Butcher, Junyu Liu, Theo Crawford, Yanni K.‐Y. Chin, Anneka Pereira Schmidt, Xinying Jia, Taylor B. Smallwood, Richard J. Clark, Jan P. Wurm, Lachlan D. Rash, Mehdi Mobli   +14 more
wiley   +2 more sources

ASIC2 dependent activation of the baroreceptors is required for the arterial baroreflex

The FASEB Journal, 2010
We have shown that deletion of acid‐sensing ion channel (ASIC2) impairs baroreflex (BR) control of the circulation. This impairment may result from loss of baroreceptor sensitivity or loss of central neuronal responsiveness, or both.
Rasna Sabharwal, Donald Morgan, Carol A Whiteis, Kamal Rahmouni, Mark W. Chapleau, Francois M. Abboud   +5 more
openaire   +1 more source

Different cervical vertebral bone quality scores for bone mineral density assessment for the patients with cervical degenerative disease undergoing ACCF/ACDF: computed tomography and magnetic resonance imaging-based study

Journal of Orthopaedic Surgery and Research, 2023
Background Bone mineral density (BMD) is important for the outcome of cervical spine surgery. As the gold standard of assessing BMD, dual-energy X-ray absorptiometry scans are often not ordered or go unreviewed in patients’ charts. As the supplement, MRI-
Zhe Wang, Jingyao Zhang, Qian Chen, Yong Huang, Yueming Song, Limin Liu, Ganjun Feng   +6 more
doaj   +1 more source

Pterostilbene Alleviates Pulmonary Fibrosis by Regulating ASIC2

, 2020
Abstract Background: Idiopathic pulmonary fibrosis (IPF) is a serious chronic disease of the respiratory system, and its current treatment have certain shortcomings and adverse effects. In this study, we evaluate the anti-fibrotic activity of pterostilbene (PTE) using an IPF model induced by TGF-β1 in vitro.Methods: A549 and AEC cells were ...
Yanfang Peng, Yingwen Zhang, Yabing Zhang, Xiuping Wang, Yukun Xia, Taisheng Ye, Zhaoyan Wu, Haoliang Ke   +7 more
openaire   +1 more source

Surface Expression of ASIC2 Inhibits the Amiloride-sensitive Current and Migration of Glioma Cells [PDF]

Journal of Biological Chemistry, 2006
Gliomas are primary brain tumors with a complex biology characterized by antigenic and genomic heterogeneity and a propensity for invasion into normal brain tissue. High grade glioma cells possess a voltage-independent, amiloride-inhibitable, inward Na+ current. This current does not exist in normal astrocytes or low grade tumor cells.
Wanda H, Vila-Carriles, Gergely Gy, Kovacs, Biljana, Jovov, Zhen-Hong, Zhou, Amit K, Pahwa, Garrett, Colby, Ogenna, Esimai, G Yancey, Gillespie, Timothy B, Mapstone, James M, Markert, Catherine M, Fuller, James K, Bubien, Dale J, Benos   +12 more
openaire   +2 more sources

Regulation of VSMC migration through association of SLP3 and ASIC2

The FASEB Journal, 2009
Previous studies from our laboratory indicate Acid‐Sensing Ion Channel 2 (ASIC2) inhibits chemotactic migration in vascular smooth muscle cells (VSMC). Function of certain ASIC proteins is regulated by stomatin like proteins (SLP), a family of channel‐to‐membrane linking proteins.
Elizabeth McKey, Matthew Burford, Kimberly Gannon, Samira Grifoni, Heather Drummond   +4 more
openaire   +1 more source

ENHANCED SURFACE EXPRESSION OF ASIC2 INHIBITS VSMC MIGRATION

The FASEB Journal, 2007
Vascular smooth muscle cell (VSMC) migration plays a key role in tissue repair after arterial wall injury. Recent studies from our lab demonstrate that A cid S ensing I on C
Samira Campos Grifoni, Sydney Murphy, Heather Anne Drummond   +2 more
openaire   +1 more source

Decoding Dual Regulatory Layers: Integrating Differential Expression and Alternative Splicing Dynamics in the Evolution of Laryngeal Echolocation Across Chiropteran Lineages

Integrative Zoology, EarlyView.
We integrated short‐read and long‐read RNA‐seq data from cochlear tissues of echolocating and non‐echolocating bats to disentangle transcriptional and post‐transcriptional regulation. Echolocating bats showed neural‐function enrichment among differentially expressed genes, while alternatively spliced genes were linked to epigenetic regulation. Overlaps
Jianyu Wu, Daoyuan Hu, Min Chen, Xiuguang Mao   +3 more
wiley   +1 more source