Results 21 to 30 of about 1,183 (130)

The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis

Journal of Experimental and Clinical Cancer Research, 2017
Background The tumor acidic microenvironment, a common biochemical event in solid tumors, offers evolutional advantage for tumors cells and even enhances their aggressive phenotype.
Zhihang Zhou, Jin-Wen Song, Xue Liu
exaly   +3 more sources

ASIC1a-Dependent Potentiation of Acid-Sensing Ion Channel Currents by Cyanide [PDF]

Biomolecules
Cyanide (CN) is a potent, fast-acting toxicant that impacts endogenous biomolecules in the nervous system, including acid-sensing ion channels (ASICs), which play a vital role in various neurological and psychological conditions.
Qian Jiang, Felix Yang, Amber Sun, Yuyang Chu, Joseph Cascone, Dylan Glaser, Xiang-Ping Chu   +6 more
doaj   +2 more sources

Endogenous Neuropeptide Nocistatin Is a Direct Agonist of Acid-Sensing Ion Channels (ASIC1, ASIC2 and ASIC3) [PDF]

Biomolecules, 2019
Acid-sensing ion channel (ASIC) channels belong to the family of ligand-gated ion channels known as acid-sensing (proton-gated) ion channels. Only a few activators of ASICs are known.
Dmitry I. Osmakov, Sergey G. Koshelev, Igor A. Ivanov, Yaroslav A. Andreev, Sergey A. Kozlov   +4 more
doaj   +3 more sources

Ion-Channel Proteins in the Prepubertal Bitch Reproductive System: The Immunolocalization of ASIC2, ASIC4, and PIEZO2. [PDF]

Int J Mol Sci
Ion channels play a crucial role in various physiological processes, yet their functions in the reproductive system remain underexplored. This study investigates the expression and the localization of ASIC2, ASIC4, and PIEZO2 ion channels in the reproductive tracts of prepubertal bitches.
Mhalhel K, Cavallaro M, Pansera L, Franco GA, Montalbano G, Laurà R, Abbate F, Germanà A, Levanti M, Aragona M.   +9 more
europepmc   +3 more sources

Sa12b Improves Biological Activity of Human Degenerative Nucleus Pulposus Mesenchymal Stem Cells in a Severe Acid Environment by Inhibiting Acid-Sensitive Ion Channels

Frontiers in Bioengineering and Biotechnology, 2022
Sa12b is a wasp peptide that can inhibit acid-sensitive ion channels (ASICs). The biological effects of nucleus pulposus mesenchymal stem cells (NP-MSCs) have not been investigated. Therefore, this study investigated the effect of Sa12b on the biological
Ziyu Wang, Letian Han, Haoyu Chen, Shengquan Zhang, Sumei Zhang, Hua Zhang, Yuhao Li, Hui Tao, Jie Li   +8 more
doaj   +1 more source

A new variant of ASIC2 mediates sodium retention in nephrotic syndrome [PDF]

, 2021
Abstract Idiopathic nephrotic syndrome (INS) is characterized by proteinuria and renal Na retention leading to oedema. This Na retention is usually attributed to epithelial sodium channel (ENaC) activation following plasma aldosterone increase. However, most nephrotic patients show normal aldosterone levels.
Marc Fila, Ali Sassi, Gaëlle Brideau, Lydie Cheval, Luciana Morla, Pascal Houillier, Christine Walter, Michel Gennaoui, Laure Collignon L, Mathilde Keck, Gabrielle Planelles, Naziha Bakouh, Michel Peuchmaur, Georges Deschênes, Ignacio Anegon, Séverine Remy, Bruno Vogt, Gilles Crambert, Alain Doucet   +18 more
openaire   +1 more source

Genome-Wide Analysis Reveals Selection Signatures Involved in Meat Traits and Local Adaptation in Semi-Feral Maremmana Cattle

Frontiers in Genetics, 2021
The Maremmana cattle is an ancient Podolian-derived Italian breed raised in semi-wild conditions with distinctive morphological and adaptive traits. The aim of this study was to detect potential selection signatures in Maremmana using medium-density ...
Slim Ben-Jemaa, Gabriele Senczuk, Elena Ciani, Roberta Ciampolini, Gennaro Catillo, Mekki Boussaha, Fabio Pilla, Baldassare Portolano, Salvatore Mastrangelo   +8 more
doaj   +1 more source

Region specific contribution of ASIC2 to acidosis-and ischemia-induced neuronal injury [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2016
Acidosis in the brain plays a critical role in neuronal injury in neurological diseases, including brain ischemia. One key mediator of acidosis-induced neuronal injury is the acid-sensing ion channels (ASICs). Current literature has focused on ASIC1a when studying acid signaling. The importance of ASIC2, which is also widely expressed in the brain, has
Nan, Jiang, Junjun, Wu, Tiandong, Leng, Tao, Yang, Yufan, Zhou, Qian, Jiang, Bin, Wang, Youjia, Hu, Yong-Hua, Ji, Roger P, Simon, Xiang-Ping, Chu, Zhi-Gang, Xiong, Xiang-Ming, Zha   +12 more
openaire   +2 more sources

Genome-Wide Association Studies Reveal Neurological Genes for Dog Herding, Predation, Temperament, and Trainability Traits

Frontiers in Veterinary Science, 2021
Genome-wide association study (GWAS) using dog breed standard values as phenotypic measurements is an efficient way to identify genes associated with morphological and behavioral traits.
Shuwen Shan, Fangzheng Xu, Bertram Brenig   +2 more
doaj   +1 more source

The Novel ASIC2 Locus Is Associated with Severe Gingival Inflammation

JDR Clinical & Translational Research, 2016
An increasing body of evidence suggests a significant genetic regulation of inflammatory response mechanisms; however, little is known regarding the genetic determinants of severe gingival inflammation (GI). We conducted a genome-wide association study of severe GI among 4,077 European American adults, participants in the Dental ...
Shaoping, Zhang, Kimon, Divaris, Kevin, Moss, Ning, Yu, Silvana, Barros, Julie, Marchesan, Thiago, Morelli, Cary, Agler, Steven J, Kim, Di, Wu, Kari E, North, James, Beck, Steven, Offenbacher   +12 more
openaire   +3 more sources