ASIC2 Subunits Facilitate Expression at the Cell Surface and Confer Regulation by PSD-95
PLoS ONE, 2014 Acid-sensing ion channels (ASICs) are Na+ channels activated by changes in pH within the peripheral and central nervous systems. Several different isoforms of ASICs combine to form trimeric channels, and their properties are determined by their subunit ...
Anne Marie S Harding +1 more
exaly +5 more sources
The mechanosensitive ion channel ASIC2 mediates both proprioceptive sensing and spinal alignment [PDF]
Experimental Physiology, 2023 By translating mechanical forces into molecular signals, proprioceptive neurons provide the CNS with information on muscle length and tension, which is necessary to control posture and movement.
Bavat Bornstein +9 more
doaj +4 more sources
Pterostilbene alleviates pulmonary fibrosis by regulating ASIC2 [PDF]
Chinese Medicine, 2021 Background Idiopathic pulmonary fibrosis (IPF) is a serious chronic disease of the respiratory system, but its current treatment has certain shortcomings and adverse effects.
Yanfang Peng +4 more
doaj +3 more sources
Acid-sensing ion channel 1a deficiency drives endocrine hypertension in male mice. [PDF]
J PhysiolAbstract figure legend Acid‐sensing ion channel 1a deficiency drives endocrine hypertension in aged male mice. Global deletion of ASIC1a (Asic1a−/−) in adult male mice (6 months old) elevates corticosterone, leading to hypokalaemia, volume expansion, increased pulse pressure and cardiomyocyte hypertrophy.
Garcia SM +9 more
europepmc +2 more sources
Local Ancestry and Adaptive Introgression in Xiangnan Cattle [PDF]
BiologyExploring the genetic landscape of native cattle is an exciting avenue for elucidating nuanced patterns of genetic variation and adaptive dynamics. Xiangnan cattle, a native Chinese cattle breed mainly produced in Hunan Province, are well adapted to the ...
Huixuan Yan +9 more
doaj +2 more sources
Commentary: Effects of combined treatment with transcranial and peripheral electromagnetic stimulation on performance and pain recovery from delayed onset muscle soreness induced by eccentric exercise in young athletes. A randomized clinical trial [PDF]
Frontiers in PhysiologyBalázs Sonkodi, Balázs Sonkodi
doaj +2 more sources
Acid-Sensing Ion Channel 2: Function and Modulation
Membranes, 2022 Acid-sensing ion channels (ASICs) have an important influence on human physiology and pathology. They are members of the degenerin/epithelial sodium channel family.
Andy Sivils +3 more
doaj +1 more source
Biology, 2022 Human neuroblastoma SH-SY5Y is a prominent neurobiological tool used for studying neuropathophysiological processes. We investigated acid-sensing (ASIC) and transient receptor potential vanilloid-1 (TRPV1) and ankyrin-1 (TRPA1) ion channels present in ...
Aleksandr P. Kalinovskii +6 more
doaj +1 more source
Role of acid-sensing ion channels in hypoxia- and hypercapnia-induced ventilatory responses. [PDF]
PLoS ONE, 2018 Previous reports indicate roles for acid-sensing ion channels (ASICs) in both peripheral and central chemoreception, but the contributions of ASICs to ventilatory drive in conscious, unrestrained animals remain largely unknown.
Neil D Detweiler +4 more
doaj +1 more source
Proton and non-proton activation of ASIC channels. [PDF]
PLoS ONE, 2017 The Acid-Sensing Ion Channels (ASIC) exhibit a fast desensitizing current when activated by pH values below 7.0. By contrast, non-proton ligands are able to trigger sustained ASIC currents at physiological pHs. To analyze the functional basis of the ASIC
Ivan Gautschi +2 more
doaj +1 more source