The impact of Asic2 deletion on metabolic homeostasis in mice [PDF]
Physiological ReportsAcid‐Sensing Ion Channel 2 (Asic2) is expressed in many brain regions, including the hypothalamus, the homeostatic center for hunger‐satiety‐energy expenditure.
Madison Hamby +9 more
doaj +5 more sources
Investigating role of ASIC2 in synaptic and behavioral responses to drugs of abuse [PDF]
Frontiers in Molecular Biosciences, 2023 Drugs of abuse produce rearrangements at glutamatergic synapses thought to contribute to drug-reinforced behaviors. Acid-Sensing Ion Channels (ASICs) have been suggested to oppose these effects, largely due to observations in mice lacking the ASIC1A ...
Subhash C Gupta +2 more
exaly +6 more sources
The role of ASIC2 in glioma progression: implications for prognosis and therapeutic targeting [PDF]
PeerJGlioma, the most frequent primary intracranial tumor, is characterized by infiltrative growth in the central nervous system, pronounced invasiveness, high malignancy, and poor clinical prognosis.
Wenxiu Tian +10 more
doaj +5 more sources
The relationship between acid-sensing ion channel, ASIC2, and oncogenic β-catenin signaling in ovarian cancer [PDF]
Scientific ReportsInflammation associated with incessant ovulation plays a key role in epithelial ovarian cancer (EOC) pathogenesis. Ion channels, such as acid-sensing ion channel-2 or ASIC2 are known to be upregulated in inflammatory conditions and may play a role in ...
Tanvi Joshi +2 more
exaly +3 more sources
Mice lacking ASIC2 and βENaC are protected from high-fat-diet-induced metabolic syndrome [PDF]
Frontiers in EndocrinologyIntroductionDegenerin proteins, such as βENaC and ASIC2, have been implicated in cardiovascular function. However, their role in metabolic syndrome have not been studied.
Madison Hamby +4 more
doaj +4 more sources
A variant of ASIC2 mediates sodium retention in nephrotic syndrome [PDF]
JCI Insight, 2021 Idiopathic nephrotic syndrome (INS) is characterized by proteinuria and renal sodium retention leading to edema. This sodium retention is usually attributed to epithelial sodium channel (ENaC) activation after plasma aldosterone increase.
Marc Fila +18 more
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Loss of βENaC Prevents Hepatic Steatosis but Promotes Abdominal Fat Deposition Associated with a High-Fat Diet [PDF]
BiologyBackground: Degenerin proteins, such as Acid-Sensing Ion Channel 2 (ASIC2) and β Epithelial Na+ Channel (βENaC), have been implicated in cardiovascular function.
Madison Hamby +3 more
doaj +2 more sources
Simultaneous disruption of mouse ASIC1a, ASIC2 and ASIC3 genes enhances cutaneous mechanosensitivity. [PDF]
PLoS ONE, 2012 Three observations have suggested that acid-sensing ion channels (ASICs) might be mammalian cutaneous mechanoreceptors; they are structurally related to Caenorhabditis elegans mechanoreceptors, they are localized in specialized cutaneous mechanosensory ...
Sinyoung Kang +7 more
doaj +4 more sources
Bone marrow monocytes and macrophages from mice lacking βENaC and ASIC2 have a reduced chemotactic migration response and polarization [PDF]
Physiological ReportsThe monocyte–macrophage system plays an important role in phagocytosis of pathogens and cellular debris following infection or tissue injury in several pathophysiological conditions.
Robert Wasson +4 more
doaj +2 more sources
Potential Implications of Acid-Sensing Ion Channels ASIC2 and ASIC4 in Gonadal Differentiation of Dicentrarchus labrax Subjected to Water Temperature Increase during Gonadal Development [PDF]
AnimalsIn this study, the expression and implication of acid-sensing ion channels 2 and 4 (ASIC2 and ASIC4) in the gonadal sex differentiation of Dicentrarchus labrax (D.
Kamel Mhalhel +7 more
doaj +2 more sources