Results 41 to 50 of about 1,183 (130)
Loci associated with conception rate in crossbred beef heifers.
PLoS ONE, 2020 The inability of beef cattle to maintain full term pregnancies has become an economic concern for the beef industry. Herd management and nutritional improvements have alleviated environmental impacts on embryonic and fetal loss, yet additional gains can ...
K F Oliver +7 more
doaj +1 more source
Impact and Crystallization Modeling of the Sudbury Basin and Its Implications for a Hadean Crust
Journal of Geophysical Research: Planets, Volume 131, Issue 6, June 2026.Abstract The 1.85 Ga Sudbury Structure hosts Earth's largest and best‐preserved impact‐induced melt sheet, the Sudbury Igneous Complex (SIC), which crystallized into distinct noritic, gabbroic, and granophyric layers. We conduct impact simulations with iSALE‐2D and crystallization modeling using alphaMELTS 2 to track the formation and evolution of the ...
Nicolas B. Litza +10 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2015 Acid-sensing ion channels (ASICs) are activated by an increase in the extracellular proton concentration. There are four genes (ASIC1-4) that encode six subunits, and they are involved in diverse neuronal functions, such as mechanosensation, learning and
Antonia eGonzález-Garrido +4 more
doaj +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.This study identifies ASIC1a as a key modulator of neuroinflammation following traumatic brain injury. Pharmacological inhibition of ASIC1a mitigates neuronal pyroptosis and improves neurological outcomes, a protective effect closely associated with the downregulation of the NF‐κB/NLRP3 signaling axis.
Jiawei Liang +9 more
wiley +1 more source
Physiological Reports, Volume 14, Issue 5, March 2026.Abstract Cardiac afferent neurons have been shown to trigger overactivation of neurohormonal systems known to drive adverse cardiac remodeling following myocardial infarction (MI). Acid‐sensing ion channels (ASICs) that are highly expressed in cardiac sympathetic afferents sense ischemia‐induced myocardial acidosis.
Karley M. Monaghan +14 more
wiley +1 more source
Astrocytic TCF7L2 Impacts Brain Osmoregulation and Restricts Neuronal Excitability
Glia, Volume 74, Issue 2, February 2026.Astrocytic TCF7L2 impacts extracellular glutamate and glutamine levels. Loss of astrocytic TCF7L2 disrupts extracellular potassium clearance. TCF7L2‐dependent astrocytic changes reduce neuronal excitability. ABSTRACT Astrocytes differentiate and mature during postnatal development, but the molecular mechanisms linking their maturation to neuronal ...
Mariusz Popek +10 more
wiley +1 more source
Advanced Science, Volume 13, Issue 6, 30 January 2026.This study describes derivation of two distinct mechanosensory subpopulations from human pluripotent stem cells using a transcription factor mediated approach. Of significance, functional interrogation of induced mechanosensory subtypes reveal their unique responses to mechanical stimulation in the absence of end‐organs.
Amy J. Hulme +12 more
wiley +1 more source
Sensory Neuroscience, Volume 1, Issue 3, December 2025.ABSTRACT Sensory neuron disorders, such as peripheral neuropathies and trigeminal neuralgia, cause chronic pain and sensory dysfunction; however, regenerative treatments are limited. Human pluripotent stem cells (hPSCs) provide a powerful platform to model these diseases by generating functional sensory neuron subtypes, including nociceptors and ...
Pushpanathan Muthuirulan +3 more
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Ion channels
British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +86 more
wiley +1 more source
Characterisation of spinal ligaments in the embryonic chick
Journal of Anatomy, Volume 247, Issue 6, Page 1174-1186, December 2025.Use of the embryonic chick provides an opportunity to examine the maturation of spinal ligaments during development, to inform anatomical defects in the spine. Abstract Ligaments are important connective tissues within the musculoskeletal system that connect bone to bone and provide support and stability.
Sarah Hennigan +2 more
wiley +1 more source