Coat colours in the Massese sheep breed are associated with mutations in the agouti signalling protein (ASIP) and melanocortin 1 receptor (MC1R) genes [PDF]
Animal, 2011 Massese is an Italian dairy sheep breed characterized by animals with black skin and horns and black or apparent grey hairs. Owing to the presence of these two coat colour types, this breed can be considered an interesting model to evaluate the effects ...
Luca Fontanesi +2 more
exaly +5 more sources
Blocking ASIP to Protect MC1R Signaling and Mitigate Melanoma Risk: An In Silico Study [PDF]
PharmaceuticalsBackground: Melanin protects skin and hair from the effects of ultraviolet (UV) radiation damage, which contributes to all forms of skin cancer, including melanoma.
Farah Maarfi +3 more
doaj +2 more sources
Skin transcriptomic and selection signature analyses identify ASIP as a key gene in cattle coat color determination [PDF]
Frontiers in GeneticsObjectiveCoat color is a complex trait and plays an important role in breed identification. However, information regarding genes associated with coat color in cattle is limited, especially at the skin transcriptome level.MethodsWe investigated the ...
Xin Wang +10 more
doaj +2 more sources
Understanding the skin blackening phenomenon in Youzhou Dark goats based on the histological characteristics of melanocytes [PDF]
Journal of Advanced Veterinary and Animal ResearchObjective: The study was conducted to identify the molecular mechanism of the phenotype formation of Youzhou black sheep by histological cytology and transcriptomics.
Cancan Chen +7 more
doaj +2 more sources
Integrated genomic and structural dissection of melanism in Indian leopard (Panthera pardus fusca) [PDF]
BMC GenomicsBackground Melanism in wild felids represents an intriguing evolutionary trait, potentially advantageous under specific ecological conditions, but the genetic basis of this phenotype remains unclear in many populations.
Avijit Ghosh +7 more
doaj +2 more sources
Alteration of sheep coat color pattern by disruption of ASIP gene via CRISPR Cas9
Scientific Reports, 2017 Coat color is an important characteristic and economic trait in domestic sheep. Aiming at alteration of Chinese merino sheep coat color by genome manipulation, we disrupted sheep agouti signaling protein gene by CRISPR/Cas9.
Xuemei Zhang +14 more
exaly +2 more sources
How the Leopard Hides Its Spots: ASIP Mutations and Melanism in Wild Cats [PDF]
PLoS ONE, 2012 The occurrence of melanism (darkening of the background coloration) is documented in 13 felid species, in some cases reaching high frequencies at the population level. Recent analyses have indicated that it arose multiple times in the Felidae, with three
Warren E Johnson +2 more
exaly +2 more sources
Preliminary investigation of potential links between pigmentation variants and opioid analgesic effectiveness in horses during cerebrospinal fluid centesis [PDF]
BMC Veterinary ResearchBackground The pleiotropic effects of the melanocortin system show promise in overcoming limitations associated with large variations in opioid analgesic effectiveness observed in equine practice. Of particular interest is variation in the melanocortin-1-
Elouise K. Bacon +5 more
doaj +2 more sources
Multicenter proteome-wide Mendelian randomization study identifies causal plasma proteins in melanoma and non-melanoma skin cancers [PDF]
Communications BiologyThis study addresses the diagnostic and therapeutic challenges in malignant melanoma (MM) and non-melanoma skin cancers (NMSC). We aim to identify circulating proteins causally linked to MM and NMSC traits using a multicenter Mendelian randomization (MR)
Yajia Li +3 more
doaj +2 more sources
The Genetic Basis of Melanism in Abert’s Squirrel (Sciurus aberti) [PDF]
AnimalsMelanism is widespread in different taxa and has been hypothesized to provide adaptive benefits in certain environments. Melanism is typically caused by mutations in one of two regulatory genes: the Melanocortin 1 Receptor (MC1R) or the Agouti Signaling ...
Lake H. Barrett +2 more
doaj +2 more sources