Results 1 to 10 of about 16,379 (162)

TET2 orchestrates YAP signaling to potentiate targetable vulnerability in hepatocellular carcinoma [PDF]

Cell Death and Disease
Hepatocellular carcinoma (HCC) is a leading cause of global cancer-associated mortality. Although various therapies have substantially ameliorated clinical outcome, patients invariably suffer from cancer relapse, highlighting the need for more optimized ...
Jing He, Mingen Lin, Fei Teng, Xue Sun, Ziyin Tian, Jiaxi Li, Yan Ma, Yue Dai, Yi Gao, Hongchen Li, Tongguan Tian, Kai Xu, Xinxing Li, Lei Lv, Yanping Xu   +14 more
doaj   +2 more sources

MC1R Is a Prognostic Marker and Its Expression Is Correlated with MSI in Colorectal Cancer

Current Issues in Molecular Biology, 2021
Melanocortin 1 receptor (MC1R) is thought to be a marker of poor prognosis and a potential target for the treatment of melanoma. Studies have found that MC1R promotes several tumor behaviors, including cell proliferation and differentiation, pigment ...
Lixiong Peng, Jiang Chang, Xilin Liu, Shiying Lu, Honglin Ren, Xiaoshi Zhou, Zengshan Liu, Pan Hu   +7 more
doaj   +1 more source

Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson’s disease

Molecular Neurodegeneration, 2022
Background Epidemiological studies suggest a link between the melanoma-related pigmentation gene melanocortin 1 receptor (MC1R) and risk of Parkinson’s disease (PD).
Waijiao Cai, Pranay Srivastava, Danielle Feng, Yue Lin, Charles R. Vanderburg, Yuehang Xu, Pamela Mclean, Matthew P. Frosch, David E. Fisher, Michael A. Schwarzschild, Xiqun Chen   +10 more
doaj   +1 more source

MC1R signaling through the cAMP-CREB/ATF-1 and ERK-NFκB pathways accelerates G1/S transition promoting breast cancer progression

npj Precision Oncology, 2023
MC1R, a G-protein coupled receptor, triggers ultraviolet light-induced melanin synthesis and DNA repair in melanocytes and is implicated in the pathogenesis of melanoma.
Vipin Shankar Chelakkot, Kiara Thomas, Todd Romigh, Andrew Fong, Lin Li, Shira Ronen, Shuyang Chen, Pauline Funchain, Ying Ni, Joshua Arbesman   +9 more
doaj   +1 more source

The role of melanocortin 1 receptor on melanogenesis pathway in skin color differentiation of red tilapia

Aquaculture Reports, 2022
The skin color differentiation and variation are the main problems limiting the development of red tilapia commercial culture. The specific function and regulation mechanism of mc1r gene in fish pigmentation are still poorly understood. In this study, we
Lan-mei Wang, Bing-jie Jiang, Wen-bin Zhu, Jian-jun Fu, Ming-kun Luo, Wei Liu, Zai-jie Dong   +6 more
doaj   +1 more source

Effect of polymorphisms in the 5’-flanking sequence of MC1R on feather color in Taihang chickens

Poultry Science, 2022
: MC1R plays an important role in the regulation of the formation, transfer, and deposition of melanin in animals and is important for determining coat color.
Yekai Fan, Xianwen Wu, Yamin Li, Haiyin Han, Yifan Zhang, Junqi Yang, Yufang Liu   +6 more
doaj   +1 more source

Pigment Intensity in Dogs is Associated with a Copy Number Variant Upstream of KITLG. [PDF]

, 2020
Dogs exhibit a wide variety of coat color types, and many genes have been identified that control pigment production, appearance, and distribution. Some breeds, such as the Nova Scotia Duck Tolling Retriever (NSDTR), exhibit variation in pheomelanin ...
Affolter, Verena, Bannasch, Danika, Grahn, Robert, Kallenberg, Angelica, Rebhun, Robert, Weich, Kalie, York, Daniel   +6 more
core   +2 more sources

Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats

Journal of Neuroinflammation, 2021
Background Microglia-mediated neuroinflammation plays a crucial role in the pathogenesis of hypoxic-ischemic (HI)-induced brain injury. Activation of melanocortin-1 receptor (MC1R) has been shown to exert anti-inflammatory and neuroprotective effects in ...
Shufeng Yu, Desislava Met Doycheva, Marcin Gamdzyk, Yijun Yang, Cameron Lenahan, Gaigai Li, Dujuan Li, Lifei Lian, Jiping Tang, Jun Lu, John H. Zhang   +10 more
doaj   +1 more source

Phenotypic and Genetic Features that Differ Between Hereditary and Sporadic Melanoma: Results of a Preliminary Study from a Single Center from Turkey

Dermatology Practical & Conceptual, 2023
Introduction: We have observed that most cutaneous melanoma patients under our supervision lack characteristic phenotypical features for melanoma. In contrast; history of cancers other than melanoma and age at onset before 50 were common.
Aysel Çakır, Gonca Elcin, Saadettin Kilickap, Özay Gököz, Zihni Ekim Taskiran, İsmail Celik   +5 more
doaj   +1 more source

Molecular Marker-Assisted Selection of Green Shank and White Feather Traits in Chickens

Guangdong nongye kexue, 2023
【Objective】The shank and feather color, as the characteristic traits of breeds, which remains an important selective trait in the breeding process of new varieties.
Xuewen CHAI, Jishang GONG, Fangfang CUI, Zhaofeng KANG, Yanping WU, Min ZHOU, Xuemei SUN, Jiguo XU   +7 more
doaj   +1 more source