Results 1 to 10 of about 9,263 (182)

MC1R and the response of melanocytes to ultraviolet radiation [PDF]

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005
The constitutive color of our skin plays a dramatic role in our photoprotection from solar ultraviolet radiation (UVR) that reaches the Earth and in minimizing DNA damage that gives rise to skin cancer. More than 120 genes have been identified and shown to regulate pigmentation, one of the key genes being melanocortin 1 receptor (MC1R) that encodes the
Zalfa Abdel-Malek
exaly   +3 more sources

Associations of MC1R Substitutions With Body Color Variation in a Desert Lizard [PDF]

Ecology and Evolution
Body color variation is widespread among animals, and the melanocortin 1 receptor (MC1R) acts as a vital switch gene in regulating pigmentation. A small number of amino acid substitutions, or even a single one, in MC1R are known to influence the body ...
Haojie Tong, Qianjin Lin, Shuangyue Shi, Kaixin Wang, Yaxin Guo, Richard P. Brown, Yuanting Jin   +6 more
doaj   +2 more sources

MC1R depalmitoylation inhibition reveals a physiological role for pheomelanin. [PDF]

PNAS Nexus
Abstract Pheomelanin is a sulfur-containing pigment produced by melanocytes notably in individuals with red hair/fair skin and animals with orange integumentary structures. Pheomelanin is not photoprotective as the dark eumelanin, but is cytotoxic, being related to a high risk of melanoma independently of UV radiation.
Galván I, García-Guerra M, Araujo-Roque M.   +2 more
europepmc   +3 more sources

MC1R Is a Prognostic Marker and Its Expression Is Correlated with MSI in Colorectal Cancer

Current Issues in Molecular Biology, 2021
Melanocortin 1 receptor (MC1R) is thought to be a marker of poor prognosis and a potential target for the treatment of melanoma. Studies have found that MC1R promotes several tumor behaviors, including cell proliferation and differentiation, pigment ...
Lixiong Peng, Jiang Chang, Xilin Liu, Shiying Lu, Honglin Ren, Xiaoshi Zhou, Zengshan Liu, Pan Hu   +7 more
doaj   +1 more source

Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson’s disease

Molecular Neurodegeneration, 2022
Background Epidemiological studies suggest a link between the melanoma-related pigmentation gene melanocortin 1 receptor (MC1R) and risk of Parkinson’s disease (PD).
Waijiao Cai, Pranay Srivastava, Danielle Feng, Yue Lin, Charles R. Vanderburg, Yuehang Xu, Pamela Mclean, Matthew P. Frosch, David E. Fisher, Michael A. Schwarzschild, Xiqun Chen   +10 more
doaj   +1 more source

The MC1R Gene and Youthful Looks [PDF]

Current Biology, 2016
Looking young for one's age has been a desire since time immemorial. This desire is attributable to the belief that appearance reflects health and fecundity. Indeed, perceived age predicts survival [1] and associates with molecular markers of aging such as telomere length [2]. Understanding the underlying molecular biology of perceived age is vital for
Liu, F., Hamer, M.A., Deelen, J., Lall, J.S., Jacobs, L., Heemst, D. van, Murray, P.G., Wollstein, A., Craen, A.J.M. de, Uh, H.W., Zeng, C.Q., Hofman, A., Uitterlinden, A.G., Houwing-Duistermaat, J.J., Pardo, L.M., Beekman, M., Slagboom, P.E., Nijsten, T., Kayser, M., Gunn, D.A.   +19 more
openaire   +5 more sources

The role of melanocortin 1 receptor on melanogenesis pathway in skin color differentiation of red tilapia

Aquaculture Reports, 2022
The skin color differentiation and variation are the main problems limiting the development of red tilapia commercial culture. The specific function and regulation mechanism of mc1r gene in fish pigmentation are still poorly understood. In this study, we
Lan-mei Wang, Bing-jie Jiang, Wen-bin Zhu, Jian-jun Fu, Ming-kun Luo, Wei Liu, Zai-jie Dong   +6 more
doaj   +1 more source

Evidence for Variable Selective Pressures at MC1R [PDF]

The American Journal of Human Genetics, 2000
It is widely assumed that genes that influence variation in skin and hair pigmentation are under selection. To date, the melanocortin 1 receptor (MC1R) is the only gene identified that explains substantial phenotypic variance in human pigmentation. Here we investigate MC1R polymorphism in several populations, for evidence of selection. We conclude that
Harding, Rosalind M., Healy, Eugene, Ray, Amanda J., Ellis, Nichola S., Flanagan, Niamh, Todd, Carol, Dixon, Craig, Sajantila, Antti, Jackson, Ian J., Birch-Machin, Mark A., Rees, Jonathan L.   +10 more
openaire   +4 more sources

MC1R signaling through the cAMP-CREB/ATF-1 and ERK-NFκB pathways accelerates G1/S transition promoting breast cancer progression

npj Precision Oncology, 2023
MC1R, a G-protein coupled receptor, triggers ultraviolet light-induced melanin synthesis and DNA repair in melanocytes and is implicated in the pathogenesis of melanoma.
Vipin Shankar Chelakkot, Kiara Thomas, Todd Romigh, Andrew Fong, Lin Li, Shira Ronen, Shuyang Chen, Pauline Funchain, Ying Ni, Joshua Arbesman   +9 more
doaj   +1 more source

Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats

Journal of Neuroinflammation, 2021
Background Microglia-mediated neuroinflammation plays a crucial role in the pathogenesis of hypoxic-ischemic (HI)-induced brain injury. Activation of melanocortin-1 receptor (MC1R) has been shown to exert anti-inflammatory and neuroprotective effects in ...
Shufeng Yu, Desislava Met Doycheva, Marcin Gamdzyk, Yijun Yang, Cameron Lenahan, Gaigai Li, Dujuan Li, Lifei Lian, Jiping Tang, Jun Lu, John H. Zhang   +10 more
doaj   +1 more source