Results 31 to 40 of about 9,263 (182)

Palmitoylation-dependent activation of MC1R prevents melanomagenesis [PDF]

Nature, 2017
The melanocortin-1 receptor (MC1R), a G-protein-coupled receptor, has a crucial role in human and mouse pigmentation. Activation of MC1R in melanocytes by α-melanocyte-stimulating hormone (α-MSH) stimulates cAMP signalling and melanin production and enhances DNA repair after ultraviolet irradiation.
Chen, Shuyang, Zhu, Bo, Yin, Chengqian, Liu, Wei, Han, Changpeng, Liu, Tongzheng, Li, Xin, Chen, Xiang, Li, Chunying, Hu, Limin, Zhou, Jun, Xu, Zhi-Xiang, Gao, Xiumei, Goding, Colin R., Cui, Rutao, Chen, Baoen, Wu, Xu   +16 more
openaire   +5 more sources

Assessing losses of genetic variability in the endangered Mallorquí horse

Czech Journal of Animal Science, 2010
Information contained in the studbook of the endangered Mallorquí horse was analysed to assess the genetic variability of the breed. Also, the effect of selection for coat colour variation was assessed using a set of 15 microsatellites genotyped on 68 ...
I. Álvarez, L.J. Royo, L. Pérez-Pardal, I. Fernández, L. Payeras, F. Goyache   +5 more
doaj   +1 more source

Distinct pigmentary and melanocortin 1 receptor-dependent components of cutaneous defense against ultraviolet radiation. [PDF]

PLoS Genetics, 2007
Genetic variation at the melanocortin 1 receptor (MC1R) is an important risk factor for developing ultraviolet (UV) radiation-induced skin cancer, the most common form of cancer in humans.
Craig S April, Gregory S Barsh
doaj   +1 more source

Attenuation Effect of Radiofrequency Irradiation on UV-B-Induced Skin Pigmentation by Decreasing Melanin Synthesis and through Upregulation of Heat Shock Protein 70

Molecules, 2021
Excess melanin deposition in the skin causes cosmetic problems. HSP70 upregulation decreases microphthalmia-associated transcription factor (MITF) expression, which eventually decreases tyrosinase activity and melanogenesis.
Hyoung Moon Kim, Seyeon Oh, Chang Hu Choi, Jin Young Yang, Sunggeun Kim, Donghwan Kang, Kuk Hui Son, Kyunghee Byun   +7 more
doaj   +1 more source

Lack of somatic alterations of MC1R in primary melanoma [PDF]

Pigment Cell & Melanoma Research, 2008
SummaryGermline variation of the melanocortin 1 receptor gene (MC1R) is a risk factor for cutaneous melanoma. Recent studies have indicated that the risk is significantly higher for melanomas with somatic BRAF mutations, suggesting that MC1R variants may have a more specific role than their demonstrated effects on skin and hair pigmentation. To address
Kim, R. D., Curtin, John, Bastian, Boris C.   +2 more
openaire   +3 more sources

Melanocortin 1 Receptor Regulates Pathological and Physiological Cardiac Remodeling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The melanocortin 1 receptor (MC1R) is abundantly expressed in the skin and leukocytes, where it regulates skin pigmentation and inflammatory responses.
Anni Suominen, Aino Suni, Saku Ruohonen, Zoltán Szabó, Lotta Pohjolainen, Minying Cai, Eriika Savontaus, Virpi Talman, Risto Kerkelä, Petteri Rinne   +9 more
doaj   +1 more source

Specific mutations in the genes of MC1R and TYR have an important influence on the determination of pheomelanin pigmentation in Korean native chickens

Journal of Advanced Veterinary and Animal Research, 2021
Objective: The TYR (Tyrosinase) and MC1R (Melanocortin 1 receptor) genes are recognized as important genes involved in plumage pigmentation in Korean native chickens. Specifically, most color patterns in chicken result from differential expression of the
In Sik Nam, Min Gee Oh, Myoung Soo Nam, Woan Sub Kim   +3 more
doaj   +1 more source

CDKN2A and MC1R analysis in amelanotic and pigmented melanoma

Melanoma Research, 2009
Amelanotic melanoma (AM) is a rare subtype of melanoma with little or no clinically visible pigment; it is more difficult to diagnose than pigmented melanoma (PM), and has a worse prognosis. In the attempt to find a genetic explanation for the distinction between AM and PM, we conducted a case-case study, matching AM and PM patients, and testing them ...
GHIORZO, PAOLA, PASTORINO, LORENZA, Pizzichetta MA, Bono R, Queirolo P, Talamini R, Annessi G, BRUNO, WILLIAM, NASTI, SABINA, GARGIULO, SARA, BATTISTUZZI, LINDA, Sini MC, Palmieri G, BIANCHI, GIOVANNA, Italian Melanoma Intergroup   +14 more
openaire   +6 more sources

Genetic Diversity, Adaptation, Wild Introgression, and Coat Color Mutation of Golden Yak

Animal Research and One Health, EarlyView.
Genetic diversity, adaptation, wild introgression, and coat color mutation of golden yak from two populations on the Qinghai‐Xizang Plateau. ABSTRACT The golden yak lives on the Qinghai‐Xizang Plateau with a golden coat and adapts to high altitudes and strong ultraviolet environment. The golden coat is a prominent phenotype in many domesticated species,
Huixuan Yan, Jialei Chen, Chuzhao Lei, Fengwei Zhang, Shunzhong He, Weiru Song, Hongyan Ma, Shuling Li, Guomei Li, Laba Yongcuo, Jianlin Han, Johannes A. Lenstra, Qiang Zhang, Rende Song, Basang Wangdui, Ningbo Chen   +15 more
wiley   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source