Journal of Animal Reproduction and Biotechnology, 2014 The objective of this study was to determine the breed differences in the 3'-untranslated region (UTR) of MC1R mRNA, which may be used to distinguish Korean brindle cattle (Chikso) from other breeds. We investigated the relationship between the variation
Hae-Lee Lee, Jae-Hee Park, Jong Gug Kim
doaj +1 more source
Nature Communications, 2023 Inhibition of T cell infiltration dampens antitumor immunity and causes resistance to immune checkpoint blockade (ICB) therapy. By in vivo CRISPR screening in B16F10 melanoma in female mice, here we report that loss of melanocortin-1 receptor (MC1R) in ...
Yazhong Cui +8 more
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An heuristic filtering tool to identify phenotype-associated genetic variants applied to human intellectual disability and canine coat colors [PDF]
, 2015 Background: Identification of one or several disease causing variant(s) from the large collection of variants present in an individual is often achieved by the sequential use of heuristic filters.
Bosmans, Tim +8 more
core +5 more sources
MC1R signaling. Intracellular partners and pathophysiological implications
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017 The melanocortin-1 receptor (MC1R) preferentially expressed in melanocytes is best known as a key regulator of the synthesis of epidermal melanin pigments. Its paracrine stimulation by keratinocyte-derived melanocortins also activates DNA repair pathways and antioxidant defenses to build a complex, multifaceted photoprotective response.
Cecilia, Herraiz +3 more
openaire +2 more sources
PLoS ONE, 2015 The melanocortin 1 receptor gene (MC1R) expressed in melanocytes is a major determinant of skin pigmentation. It encodes a Gs protein-coupled receptor activated by α-melanocyte stimulating hormone (αMSH).
Cecilia Herraiz +5 more
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The protective role of MC1R in chromosome stability and centromeric integrity in melanocytes
Cell Death Discovery, 2021 Variants in the melanocortin-1 receptor (MC1R) gene, encoding a trimeric G-protein-coupled receptor and activated by α-melanocyte-stimulating hormone (α-MSH), are frequently associated with red or blonde hair, fair skin, freckling, and skin sensitivity ...
Xin Li +6 more
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Understanding pseudo-albinism in sole (Solea senegalensis): a transcriptomics and metagenomics approach [PDF]
, 2019 Pseudo-albinism is a pigmentation disorder observed in flatfish aquaculture with a complex, multi-factor aetiology. We tested the hypothesis that pigmentation abnormalities are an overt signal of more generalised modifications in tissue structure and ...
Carballo, Carlos +7 more
core +1 more source
Current evidence for a modulation of low back pain by human genetic variants [PDF]
, 2009 The manifestation of chronic back pain depends on structural, psychosocial, occupational and genetic influences. Heritability estimates for back pain range from 30% to 45%. Genetic influences are caused by genes affecting intervertebral disc degeneration
Aberle +200 more
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Podarcis siculus latastei (Bedriaga, 1879) of the western pontine islands (italy) raised to the species rank, and a brief taxonomic overview of podarcis lizards [PDF]
, 2019 In recent years, great attention has been paid to many Podarcis species for which the observed intra-specific variability often revealed species complexes still characterized by an unresolved relationship. When compared to other species, P.
Bohme, W. +3 more
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Gene Expression Regulation by Agonist-Independent Constitutive Signaling of Melanocortin-1 Receptor [PDF]
Endocrinology and Metabolism, 2014 BackgroundMelanocortin-1 receptor (Mc1r), a key signaling receptor for melanogenesis, has been reported to mediate migration of B16F10 melanoma cells.
Ikjoo Seong, Jaesang Kim
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