Results 31 to 40 of about 11,568 (220)

Functional divergence of the pigmentation gene melanocortin-1 receptor (MC1R) in six endemic Macaca species on Sulawesi Island

Scientific Reports, 2022
Coat color is often highly variable within and between animal taxa. Among hundreds of pigmentation-related genes, melanocortin-1 receptor (MC1R) plays key roles in regulating the synthesis of the dark eumelanin and the red–yellow pheomelanin.
Xiaochan Yan, Yohey Terai, Kanthi Arum Widayati, Akihiro Itoigawa, Laurentia Henrieta Permita Sari Purba, Fahri Fahri, Bambang Suryobroto, Hiroo Imai   +7 more
doaj   +1 more source

Distinct pigmentary and melanocortin 1 receptor-dependent components of cutaneous defense against ultraviolet radiation. [PDF]

PLoS Genetics, 2007
Genetic variation at the melanocortin 1 receptor (MC1R) is an important risk factor for developing ultraviolet (UV) radiation-induced skin cancer, the most common form of cancer in humans.
Craig S April, Gregory S Barsh
doaj   +1 more source

Attenuation Effect of Radiofrequency Irradiation on UV-B-Induced Skin Pigmentation by Decreasing Melanin Synthesis and through Upregulation of Heat Shock Protein 70

Molecules, 2021
Excess melanin deposition in the skin causes cosmetic problems. HSP70 upregulation decreases microphthalmia-associated transcription factor (MITF) expression, which eventually decreases tyrosinase activity and melanogenesis.
Hyoung Moon Kim, Seyeon Oh, Chang Hu Choi, Jin Young Yang, Sunggeun Kim, Donghwan Kang, Kuk Hui Son, Kyunghee Byun   +7 more
doaj   +1 more source

MC1R variants as melanoma risk factors independent of at-risk phenotypic characteristics: a pooled-analysis from the M-SKIP project [PDF]

, 2018
Purpose: Melanoma represents an important public health problem, due to its high case-fatality rate. Identification of individuals at high risk would be of major interest to improve early diagnosis and ultimately survival.
Landi M. T., Fargnoli M. C., Raimondi Sara, Little J, Julia Newton-Bishop, Sera, Francesco, Sara Gandini, Menin, Chiara, Han, Jiali, Tagliabue, E, Garcia-Borron, J.C., Menin, C, DeAnn Lazovich, Maria Concetta Fargnoli, Kanetsky, Peter A., Newton-Bishop J., Kanetsky P. A, Menin, C., Landi MT, Jiali Han, Raimondi S, Tagliabue, Elena, Jose Carlos García-Borrón, Newton-Bishop, J, Gandini S, Maisonneuve P, Fargnoli MC, Gruis NA, Gandini, S, Polsky D., Maisonneuve, Patrick, Bellocco R, Lazovich, DeAnn, Newton-Bishop, J., Bellocco, R., Sera F, Menin C, Raimondi, S, Fargnoli, MC, Landi, Maria Teresa, M-SKIP Study Group, David Polsky, Sera, F., Rino Bellocco, Chiara Menin, Tagliabue E, Han J, Tagliabue, E., Guida S, Little J., Polsky, D, Elena Tagliabue, Little, J., Lorenza Pastorino, Lazovich D., M-SKIP sudy group, Little, J, Julian Little, Gruis, NA, Kanetsky, P.A., Gandini, Sara, Polsky, David, Peter Kanetsky, Han, J, Raimondi, Sara, Newton-Bishop J, Bellocco, R, Gruis, Nelleke A, Ghiorzo P. i, Ghiorzo, P, Maisonneuve, P, Kanetsky, PA, Lazovich D, Gruis, N.A., Patrick Maisonneuve, Gruis, Nelleke A., Sara Raimondi, Francesco Sera, Maisonneuve, P., Fargnoli, M.C., Lazovich, D., Landi, MT, Lazovich, D, Kanetsky PA, Little, Julian, Han J., Maria Teresa Landi, Gruis N. A., Landi, M.T., Garcia-Borron, JC, Han, J.L., Fargnoli, Maria Concetta, Ghiorzo P, Sera, F, Raimondi, S., Ghiorzo, Paola, Bellocco, Rino, Polsky, D., Kanetsky, Peter A, Ghiorzo, P., Gabriella Guida, García-Borrón JC, García-Borrón, Jose Carlos, Nelleke Gruis, Paola Ghiorzo, Polsky D, Gandini, S., Newton-Bishop, Julia   +107 more
core   +1 more source

Lack of somatic alterations of MC1R in primary melanoma [PDF]

Pigment Cell & Melanoma Research, 2008
SummaryGermline variation of the melanocortin 1 receptor gene (MC1R) is a risk factor for cutaneous melanoma. Recent studies have indicated that the risk is significantly higher for melanomas with somatic BRAF mutations, suggesting that MC1R variants may have a more specific role than their demonstrated effects on skin and hair pigmentation. To address
Kim, R. D., Curtin, John, Bastian, Boris C.   +2 more
openaire   +3 more sources

Melanocortin 1 Receptor Regulates Pathological and Physiological Cardiac Remodeling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The melanocortin 1 receptor (MC1R) is abundantly expressed in the skin and leukocytes, where it regulates skin pigmentation and inflammatory responses.
Anni Suominen, Aino Suni, Saku Ruohonen, Zoltán Szabó, Lotta Pohjolainen, Minying Cai, Eriika Savontaus, Virpi Talman, Risto Kerkelä, Petteri Rinne   +9 more
doaj   +1 more source

A polymorphism study of the human Agouti gene and its association with MC1R

, 2001
To determine whether the Agouti Signalling Protein (ASP) gene is associated with skin and hair coloration in humans, the complete coding region of ASP was screened for polymorphisms.
van Daal, Angela M., Box, Neil F., Voisey, Joanne   +2 more
core   +1 more source

Assessing losses of genetic variability in the endangered Mallorquí horse

Czech Journal of Animal Science, 2010
Information contained in the studbook of the endangered Mallorquí horse was analysed to assess the genetic variability of the breed. Also, the effect of selection for coat colour variation was assessed using a set of 15 microsatellites genotyped on 68 ...
I. Álvarez, L.J. Royo, L. Pérez-Pardal, I. Fernández, L. Payeras, F. Goyache   +5 more
doaj   +1 more source

Specific mutations in the genes of MC1R and TYR have an important influence on the determination of pheomelanin pigmentation in Korean native chickens

Journal of Advanced Veterinary and Animal Research, 2021
Objective: The TYR (Tyrosinase) and MC1R (Melanocortin 1 receptor) genes are recognized as important genes involved in plumage pigmentation in Korean native chickens. Specifically, most color patterns in chicken result from differential expression of the
In Sik Nam, Min Gee Oh, Myoung Soo Nam, Woan Sub Kim   +3 more
doaj   +1 more source

MC1R transcripts and intergenic splice isoforms of MC1R and TUBB3.

, 2015
(A) Schematic panel showing the exon organization of MC1R splice variants (MC1R-001 and MC1R-002) and MC1R-TUBB3 chimeric transcripts, Iso1 and Iso2. Exons of all MC1R derived transcripts are represented in colored boxes and the number of nucleotides in ...
Celia Jiménez-Cervantes (836701), José Carlos García-Borrón (836702), Marta Abrisqueta (836700), Cecilia Herraiz (836697), Maria Castejón-Griñán (836699), Conchi Olivares (836698)   +5 more
core   +1 more source