Results 41 to 50 of about 9,263 (182)

Bioinformatics Analysis of the Melanocortin 1 Receptor Gene (MC1R) in the Southern Platyfish Xiphophorus maculatus (Günther, 1866) [PDF]

International Journal Bioautomation, 2020
The Southern platyfish Xiphophorus maculatus is one of the most popular ornamental fish used widely as a premier model system in understanding the genetic basis of color pattern polymorphism. Coloration in X.
Abdul Khader Sultan Mohideen, Anbu Arun
doaj   +1 more source

Beyond the Classics: The Synergy of AI and Genomics Reveals an Expanded Repertoire of Pigmentation Genes

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Classical approaches for coloration analysis are limited by human low‐resolution phenotyping and genetic analysis. Artificial intelligence allows us to find genes beyond the tip of the iceberg that explain color and pattern diversity in nature. ABSTRACT Pigmentation has long served as a powerful system for exploring gene–trait relationships, yet much ...
Ehsan Pashay Ahi, Nidal Karagic
wiley   +1 more source

Association of MC1R variation and plumage color diversity of Nigerian domestic pigeon (Columba livia domestica)

Journal of Advanced Veterinary and Animal Research, 2022
Objectives: Domestic pigeons (Columba livia domestica) have diverse plumage pigmentations. Melanocortin 1 receptor (MC1R) gene variation has been correlated with color traits.
Xiang-Xiang Jiang, Adeniyi Charles Adeola, Foluke Eunice Sola-Ojo, Ibraheem Atolagbe Abubakar, Isiaka Hannah Fatima, Ojuerayetan Judah Olaoluwa, Abdulwahab Barakat Abodurin, Olawale Abdulafeez Olasunkanmi, Oladejo Hafsat Abisola, Oladipo Uthman, Adeshina Esther Kehinde, Hussein Hamidat, Taiwo Eyitayo Nishola, Semiu Folaniyi Bello, Min-Sheng Peng, Ya-Ping Zhang   +15 more
doaj   +1 more source

MC1R signaling. Intracellular partners and pathophysiological implications

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017
The melanocortin-1 receptor (MC1R) preferentially expressed in melanocytes is best known as a key regulator of the synthesis of epidermal melanin pigments. Its paracrine stimulation by keratinocyte-derived melanocortins also activates DNA repair pathways and antioxidant defenses to build a complex, multifaceted photoprotective response.
Cecilia, Herraiz, Jose C, Garcia-Borron, Celia, Jiménez-Cervantes, Conchi, Olivares   +3 more
openaire   +2 more sources

Cutaneous Pigmentary Changes During Setmelanotide Therapy: Dermoscopic and Confocal Findings in Two Patients

JEADV Clinical Practice, EarlyView.
ABSTRACT Setmelanotide is a melanocortin‐4 receptor agonist approved for the treatment of rare forms of genetic obesity. Through off‐target activation of the melanocortin‐1 receptor, it may induce cutaneous pigmentation changes; however, data regarding its effects on melanocytic nevi remain limited.
Martina Cavicchi, Claudia Lasagni, Silvana Ciardo, Francesca Giusti, Albino Eccher, Caterina Longo   +5 more
wiley   +1 more source

Effectiveness and Safety of Setmelanotide in a Patient With a Heterozygous PCSK1 Deficiency

Obesity, EarlyView.
ABSTRACT Setmelanotide, a melanocortin 4 receptor (MC4R) agonist, is a promising pharmacological treatment option for people with rare monogenic obesity conditions affecting the leptin‐melanocortin signaling pathway, including proprotein convertase subtilisin/kexin type 1 (PCSK1) gene mutations.
Ellina Lytvyak, Arshdeep Rattol, Eduardo Grunvald   +2 more
wiley   +1 more source

MODELLING OF 3D-STRUCTURES OF THE RARE MELANOCORTIN-1-RECEPTOR MUTATIONS ASSOCIATED TO MELANISM IN THE BANANAQUIT

Acta Biológica Colombiana, 2020
Melanism in plumage color is often associated to the single nucleotide polymorphism of the melanocortin-1-receptor (MC1R). Despite the striking association between the substitution of a Glutamic-acid by for a Lysine at position 92 on the MC1R protein and
Raúl Ernesto Sedano-Cruz, Daniel Camilo Osorio   +1 more
doaj   +1 more source

Coat colour phenotype of Qingyu pig is associated with polymorphisms of melanocortin receptor 1 gene [PDF]

Asian-Australasian Journal of Animal Sciences, 2017
Objective Qingyu pig, a Chinese indigenous pig breed, exhibits two types of coat colour phenotypes, including pure black and white with black spotting respectively.
Xiaoqian Wu, Zhendong Tan, Linyuan Shen, Qiong Yang, Xiao Cheng, Kun Liao, Lin Bai, Surong Shuai, Mingzhou Li, Xuewei Li, Shunhua Zhang, Li Zhu   +11 more
doaj   +1 more source

Fine‐scale spatial variation in eastern grey squirrel melanism across a complex urban landscape

Journal of Animal Ecology, EarlyView.
By sampling 197 parks, the study demonstrates how natural geography creates divergence within cities. The findings reveal that the St. Lawrence River and its tributaries act as barriers, disrupting urban melanism clines in grey squirrels. Ultimately, the research indicates that natural features still dictate evolutionary rules in anthropogenic ...
Francis Quang‐Hai Dinh, Isabella C. Richmond, Andrew P. Hendry, Allison M. Roth   +3 more
wiley   +1 more source

Involvement of the melanocortin-1 receptor in acute pain and pain of inflammatory but not neuropathic origin.

PLoS ONE, 2010
BackgroundResponse to painful stimuli is susceptible to genetic variation. Numerous loci have been identified which contribute to this variation, one of which, MC1R, is better known as a gene involved in mammalian hair colour. MC1R is a G protein-coupled
Ada Delaney, Margaret Keighren, Susan M Fleetwood-Walker, Ian J Jackson   +3 more
doaj   +1 more source