MC1RVariation in a New Mexico Population [PDF]
Cancer Epidemiology, Biomarkers & Prevention, 2019 AbstractBackground:The Melanocortin 1 Receptor (MC1R) contributes to pigmentation, an important risk factor for developing melanoma. Evaluating SNPs in MC1R and association with race/ethnicity, skin type, and perceived cancer risk in a New Mexico (NM) population will elucidate the role of MC1R in a multicultural population.Methods:We genotyped MC1R in ...
Kirsten A.M. White +12 more
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Scientific Reports, 2022 Coat color is often highly variable within and between animal taxa. Among hundreds of pigmentation-related genes, melanocortin-1 receptor (MC1R) plays key roles in regulating the synthesis of the dark eumelanin and the red–yellow pheomelanin.
Xiaochan Yan +7 more
doaj +1 more source
Melanism as a potential thermal benefit in eastern fox squirrels (Sciurus niger) [PDF]
, 2019 Melanistic fox squirrels (Sciurus niger) have expanded westward and increased in frequency in the Omaha, Nebraska, and Council Bluffs, Iowa, metropolitan areas.
Ciurej, Amanda K. +3 more
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The
BMC Research Notes, 2011 Background The guppy (Poecilia reticulata) is an important model organism for studying sexual selection; male guppies have complex and conspicuous pigmentation, and female guppies exhibit preferences for males with specific color spots. Understanding the
Yokoyama Jun +4 more
doaj +1 more source
Distinct pigmentary and melanocortin 1 receptor-dependent components of cutaneous defense against ultraviolet radiation. [PDF]
PLoS Genetics, 2007 Genetic variation at the melanocortin 1 receptor (MC1R) is an important risk factor for developing ultraviolet (UV) radiation-induced skin cancer, the most common form of cancer in humans.
Craig S April, Gregory S Barsh
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Molecules, 2021 Excess melanin deposition in the skin causes cosmetic problems. HSP70 upregulation decreases microphthalmia-associated transcription factor (MITF) expression, which eventually decreases tyrosinase activity and melanogenesis.
Hyoung Moon Kim +7 more
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In Vitro Behavior and UV response of melanocytes derived from carriers of CDKN2A mutations and MC1R variants. [PDF]
, 2019 Co-inheritance of germline mutation in cyclin-dependent kinase inhibitor 2A (CDKN2A) and loss-of-function (LOF) melanocortin 1 receptor (MC1R) variants is clinically associated with exaggerated risk for melanoma.
Abdel-Malek, ZA +10 more
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Melanocortin 1 Receptor Regulates Pathological and Physiological Cardiac Remodeling
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground The melanocortin 1 receptor (MC1R) is abundantly expressed in the skin and leukocytes, where it regulates skin pigmentation and inflammatory responses.
Anni Suominen +9 more
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Assessing losses of genetic variability in the endangered Mallorquí horse
Czech Journal of Animal Science, 2010 Information contained in the studbook of the endangered Mallorquí horse was analysed to assess the genetic variability of the breed. Also, the effect of selection for coat colour variation was assessed using a set of 15 microsatellites genotyped on 68 ...
I. Álvarez +5 more
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Who's behind that mask and cape? The Asian leopard cat's Agouti (ASIP) allele likely affects coat colour phenotype in the Bengal cat breed. [PDF]
, 2014 Coat colours and patterns are highly variable in cats and are determined mainly by several genes with Mendelian inheritance. A 2-bp deletion in agouti signalling protein (ASIP) is associated with melanism in domestic cats. Bengal cats are hybrids between
Davis, BW +5 more
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