Results 61 to 70 of about 16,448 (221)

In Vivo and In Vitro Evaluation of PTeCA (1H‐Pyrrole‐2,3,4,5‐Tetracarboxylic Acid) in Hair Matrix as a Marker for Oxidative Cosmetic Treatment

Drug Testing and Analysis, EarlyView.
A total of 3378 self‐reported treated and untreated hair samples were analyzed for PTCA and PTeCA by LC‐MS/MS. Moreover, their in vitro formation was assessed in 225 untreated hair by different cosmetic treatments with and without oxidative agents. Data suggest that PTeCA could be a reliable marker for oxidative cosmetic treatments in hair.
Sara Casati, Alessandro Ravelli, Roberta F. Bergamaschi, Agata Magliocco, Sofia Vanerio, Gabriella Roda, Paola Rota, Marica Orioli, Alessio Battistini   +8 more
wiley   +1 more source

Bayesian inference of natural selection from allele frequency time series

, 2016
The advent of accessible ancient DNA technology now allows the direct ascertainment of allele frequencies in ancestral populations, thereby enabling the use of allele frequency time series to detect and estimate natural selection.
Evans, Steven N., Schraiber, Joshua G., Slatkin, Montgomery   +2 more
core   +1 more source

AMPK Phosphorylates ZDHHC13 to Increase MC1R Activity and Suppress Melanomagenesis

Cancer Research, 2023
Abstract Inherited genetic variations in the melanocortin-1 receptor (MC1R) responsible for human red hair color (RHC) variants are associated with impaired DNA damage repair and increased melanoma risk.
Sun, Y, Li, X, Yin, C, Zhang, J, Liang, E, Wu, X, Ni, Y, Arbesman, J, Goding, CR, Chen, S   +9 more
openaire   +3 more sources

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

MODELLING OF 3D-STRUCTURES OF THE RARE MELANOCORTIN-1-RECEPTOR MUTATIONS ASSOCIATED TO MELANISM IN THE BANANAQUIT

Acta Biológica Colombiana, 2020
Melanism in plumage color is often associated to the single nucleotide polymorphism of the melanocortin-1-receptor (MC1R). Despite the striking association between the substitution of a Glutamic-acid by for a Lysine at position 92 on the MC1R protein and
Raúl Ernesto Sedano-Cruz, Daniel Camilo Osorio   +1 more
doaj   +1 more source

The genetic basis of color-related local adaptation in a ring-like colonization around the Mediterranean. [PDF]

, 2015
Uncovering the genetic basis of phenotypic variation and the population history under which it established is key to understand the trajectories along which local adaptation evolves.
Antoniazza, S., Burri, R., Ducrest, A.L., European Barn Owl, Network, Fumagalli, L., Gaigher, A., Goudet, J., Roulin, A., Simon, C.   +8 more
core   +1 more source

Cutaneous Squamous Cell Carcinoma Amongst Solid Organ Transplant Recipients: A Systematic Review of Molecular Alterations

JEADV Clinical Practice, EarlyView.
ABSTRACT Background As solid organ transplantation becomes more prevalent, more patients are living on long‐term immunosuppression, greatly increasing the risk of cutaneous squamous cell carcinoma (cSCC). Although significant improvements have been achieved in the treatment of cSCC, further studies are needed to identify the specific protein expression
William Murray, Robin Caird, Michael O'Connor, Ciara Drumm, Emma O'Hora, Franklin Crossen, Aoife Lally, Aurelie Fabre, Roisin Dolan   +8 more
wiley   +1 more source

Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project [PDF]

, 2012
Background: For complex diseases like cancer, pooled-analysis of individual data represents a powerful tool to investigate the joint contribution of genetic, phenotypic and environmental factors to the development of a disease.
Anno, H. (Hirofumi), Autier, P.J.M. (Philippe), Bagnardi, V. (Vincenzo), Blizzard, L. (Leigh), Branicki, W. (Wojciech), Cornelius, L. (Lynn), Debniak, T. (Tadeusz), Dwyer, T. (Terry), Fargnoli, M.C. (Maria Concetta), Fernandez-De-Misa, R. (Ricardo), Gandini, S. (Sara), García-Borrón, J.C. (José C), Ghiorzo, P. (Paola), Gruis, N.A. (Nelleke), Han, J., Hansson, J. (Johan), Helsing, P. (Per), Kanetsky, P.A. (Peter A), Kayser, M.H. (Manfred), Kumar, R. (Rajiv), Landi, M.T. (Maria Teresa), Little, J. (Julian), Liu, F. (Fan), Maisonneuve, P. (Patrick), Morling, N. (Niels), Motokawa, T. (Tomonori), Nagore, E. (Eduardo), Newton-Bishop, J. (Julia), Nijsten, T.E.C. (Tamar), Palmieri, D. (Dario), Raimondi, S. (Susana), Ribas, G. (Gloria), Sera, J.P. de, Specchia, C. (Claudia), Stratigos, A. (Alexander), Wong, T.H. (Terence)   +35 more
core   +1 more source

Effectiveness and Safety of Setmelanotide in a Patient With a Heterozygous PCSK1 Deficiency

Obesity, EarlyView.
ABSTRACT Setmelanotide, a melanocortin 4 receptor (MC4R) agonist, is a promising pharmacological treatment option for people with rare monogenic obesity conditions affecting the leptin‐melanocortin signaling pathway, including proprotein convertase subtilisin/kexin type 1 (PCSK1) gene mutations.
Ellina Lytvyak, Arshdeep Rattol, Eduardo Grunvald   +2 more
wiley   +1 more source

Involvement of the melanocortin-1 receptor in acute pain and pain of inflammatory but not neuropathic origin.

PLoS ONE, 2010
BackgroundResponse to painful stimuli is susceptible to genetic variation. Numerous loci have been identified which contribute to this variation, one of which, MC1R, is better known as a gene involved in mammalian hair colour. MC1R is a G protein-coupled
Ada Delaney, Margaret Keighren, Susan M Fleetwood-Walker, Ian J Jackson   +3 more
doaj   +1 more source