Results 61 to 70 of about 11,568 (220)

Involvement of the melanocortin-1 receptor in acute pain and pain of inflammatory but not neuropathic origin.

PLoS ONE, 2010
BackgroundResponse to painful stimuli is susceptible to genetic variation. Numerous loci have been identified which contribute to this variation, one of which, MC1R, is better known as a gene involved in mammalian hair colour. MC1R is a G protein-coupled
Ada Delaney, Margaret Keighren, Susan M Fleetwood-Walker, Ian J Jackson   +3 more
doaj   +1 more source

Coat colour phenotype of Qingyu pig is associated with polymorphisms of melanocortin receptor 1 gene [PDF]

Asian-Australasian Journal of Animal Sciences, 2017
Objective Qingyu pig, a Chinese indigenous pig breed, exhibits two types of coat colour phenotypes, including pure black and white with black spotting respectively.
Xiaoqian Wu, Zhendong Tan, Linyuan Shen, Qiong Yang, Xiao Cheng, Kun Liao, Lin Bai, Surong Shuai, Mingzhou Li, Xuewei Li, Shunhua Zhang, Li Zhu   +11 more
doaj   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

The Influence of MC1R Variants on Facial Aging Rate [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2015
Aging of the skin is influenced both by intrinsic factors, such as chronological age, and by extrinsic or environmental factors, such as chronic ultraviolet exposure and smoking. Skin photoaging is defined as premature aging of the skin due to chronic sun exposure. Variation in human skin and hair color is due to differences in the absolute amounts and
openaire   +2 more sources

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

MC1R sequences

, 2015
Columns contain the following data: Individual ID, Population, MC1R sequence (unphased, heterozygous positions are provided in IUPAC degenerate ...
Jerome Goudet (3248616), Reto Burri (481009), The European Barn Owl Network (3248613), Sylvain Antoniazza (482073), Céline Simon (482074), Luca Fumagalli (168843), Arnaud Gaigher (3194055), Alex Roulin (3248622), Anne-Lyse Ducrest (3191806)   +8 more
core   +1 more source

Variability of the mc1r gene in melanic and non-melanic Podarcis lilfordi and Podarcis pityusensis from the Balearic archipelago.

PLoS ONE, 2013
The association between polymorphism at the mc1r locus and colour variation was studied in two wall lizard species (Podarcis lilfordi and P. pityusensis) from the Balearic archipelago.
Joana M Buades, Virginia Rodríguez, Bàrbara Terrasa, Valentin Pérez-Mellado, Richard P Brown, Jose A Castro, Antònia Picornell, M M Ramon   +7 more
doaj   +1 more source

Prevalence and Grade of Patellar Luxation in Cavalier King Charles Spaniels Attending Primary‐Care Veterinary Practices in Australia

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Patella luxation was prevalent in Cavalier King Charles Spaniels attending Australian veterinary practices. Dogs which were younger, neutered, above the breed standard weight, and with ruby‐coloured coats were at increased risk, while dogs with bilateral luxation were more likely to be diagnosed with higher grade luxation .
Yaeji Son, Marianne D. Keller, Peter Williamson, Rosanne M. Taylor   +3 more
wiley   +1 more source

AMPK phosphorylates ZDHHC13 to increase MC1R activity and suppress melanomagenesis

, 2023
Inherited genetic variations in the melanocortin-1 receptor (MC1R) responsible for human red hair color (RHC-variants) are associated with impaired DNA damage repair and increased melanoma risk.
Arbesman, Joshua, Chen, Shuyang, Sun, Yu, Yin, Chengqian, Ni, Ying, Goding, Colin R, Zhang, Judy, Liang, Ershang, Li, Xin, Wu, Xianfang   +9 more
core   +1 more source

Environmental correlates of spatio‐temporal patterns of colour variation in a bird of prey: The common buzzard (Buteo buteo)

Ibis, Volume 168, Issue 3, Page 985-1001, July 2026.
High colour variability in animals has been associated with adaptability to environmental change. Establishing how such variability is distributed in time and space, and identifying environmental correlates, can help understand the processes driving it.
Kaspar Delhey, Elena F. Kappers, Mihai Valcu, Christiaan Both, Bart Kempenaers   +4 more
wiley   +1 more source