Results 61 to 70 of about 9,263 (182)

Through the Sands of Time: Evolutionary History and Systematics of the Awl‐Headed Snakes (Colubridae: Lytorhynchus) in the Saharo‐Sindian Region

Zoologica Scripta, EarlyView.
ABSTRACT The psammophilous colubrid genus Lytorhynchus is widely distributed in the deserts of the Saharo‐Sindian region and adjacent areas. The taxonomy of the genus and the number of recognised species have remained unstable since the last taxonomic revision in 1970, with differing views on the taxonomic status of L. gaddi and L. kennedyi.
Lukáš Pola, Daniel Jablonski, Rafaqat Masroor, Bassam Abu Afifeh, Roberta Graboski, Mohammad Abu Baker, Zuhair S. Amr, Ahmed Mohajja AlShammari, Avrajjal Ghosh, Salvador Carranza, Jiří Šmíd   +10 more
wiley   +1 more source

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 468-484, September 2026.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Melanocortin 1 receptor mediates melanin production by interacting with the BBSome in primary cilia.

PLoS Biology
Production of melanin pigments is a protective mechanism of the skin against ultraviolet (UV)-induced damage and carcinogenesis. However, the molecular basis for melanogenesis is still poorly understood.
Xiaoyu Tian, Hanyu Wang, Song Liu, Wei Liu, Kaiyue Zhang, Xiaohan Gao, Qingchao Li, Huijie Zhao, Liangran Zhang, Peiwei Liu, Min Liu, Youjun Wang, Xueliang Zhu, Rutao Cui, Jun Zhou   +14 more
doaj   +1 more source

Activation of the melanocortin-1 receptor attenuates neuronal apoptosis after traumatic brain injury by upregulating Merlin expression

Brain Research Bulletin
Traumatic brain injury (TBI) is a common disease worldwide with high mortality and disability rates. Besides the primary mechanical injury, the secondary injury associated with TBI can also induce numerous pathological changes, such as brain edema, nerve
Jinqi Lu, Jin Wang, Haibo Ni, Bing Li, Jingjing Yang, Jie Zhu, Jie Qian, Rong Gao, Rong Xu   +8 more
doaj   +1 more source

Untangling the Copy Number Variation at the Basis of Belted Phenotypes in Cattle Using Long‐Read Sequencing

Animal Genetics, Volume 57, Issue 4, August 2026.
ABSTRACT The belted phenotype in cattle, a distinctive white belt across the midsection observed in breeds such as the Dutch Belted and Belted Galloway, is caused by a copy number variant (CNV) upstream of TWIST2, a gene involved in melanocyte development.
Rensco A. H. Hogers, Mirte Bosse, Annemieke P. Rattink, Rayner González‐Prendes, Marta Gòdia, Kimberley Laport, Martien A. M. Groenen, Richard P. M. A. Crooijmans, Aniek C. Bouwman   +8 more
wiley   +1 more source

Crucial role of the melanocortin receptor MC1R in experimental colitis [PDF]

Gut, 2006
Background and aims: α-Melanocyte stimulating hormone (αMSH) is known to exert anti-inflammatory effects, for example in murine DSS (dextran sodium sulphate induced) colitis. The anti-inflammatory functions of αMSH are mediated by the melanocortin1-receptor (MC1R) in an autoregulatory loop.
C, Maaser, K, Kannengiesser, C, Specht, A, Lügering, T, Brzoska, T A, Luger, W, Domschke, T, Kucharzik   +7 more
openaire   +2 more sources

The Mottling Phenotype in Chickens Shows Genetic Heterogeneity and Is Caused by Mutations at the EDNRB2 Locus

Animal Genetics, Volume 57, Issue 4, August 2026.
ABSTRACT Mottling is a widespread intra‐feather pattern present in many breeds of domestic chickens worldwide and inherited as an autosomal recessive trait. An amino acid substitution Arg332His in the EDNRB2 gene was previously reported as responsible for the mottling phenotype in several Japanese breeds of chickens.
Jingyi Li, Chiara Bortoluzzi, McKaela Hodge, Bertrand Bed'hom, Yifan Guo, Brian Davis, Benjamin Dorshorst, Paul Siegel, David Gourichon, Michèle Tixier‐Boichard, Leif Andersson   +10 more
wiley   +1 more source

Melanocortin-1 receptor expression as a predictive factor for postoperative outcomes in melanoma patients: a retrospective study

Frontiers in Immunology
Background and objectiveThis study aims to explore the relationship between melanocortin-1 receptor (MC1R) expression levels and clinical pathological parameters of melanoma, as well as its potential as a prognostic biomarker.MethodsThis retrospective ...
Tian Xiang, Tian Xiang, Haiying Li, Xiaowei Wang, Danke Su   +4 more
doaj   +1 more source

A Novel Pale-Yellow Coat Color of Rabbits Generated viaMC1R Mutation With CRISPR/Cas9 System

Frontiers in Genetics, 2019
Coat color is of great importance in animal breed characteristics; it is not only a significant productive trait but also an indispensable economic trait, especially in the rabbit industry.
Ning Xiao, Hongli Li, Laiba Shafique, Shanshan Zhao, Xiaoping Su, Yu Zhang, Kuiqing Cui, Qingyou Liu, Deshun Shi   +8 more
doaj   +1 more source

The Synthetic Melanocortin Agonist NDP‐MSH Ameliorates THSD7A‐Associated Membranous Nephropathy in an Active Immunization Mouse Model

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Active immunization with recombinant THSD7A in mice induces autoreactive B cell activation and differentiation into CD138+ antibody‐secreting cells, leading to the production of anti‐THSD7A autoantibodies, glomerular immune injury and proteinuria, characteristic of membranous nephropathy. NDP‐MSH treatment modulates the MITF/IRF4 axis in primed B cells,
Mingzhuo Zhang, Mengxuan Chen, Yan Ge, William Gunning, Rujun Gong   +4 more
wiley   +1 more source