Results 81 to 90 of about 16,448 (221)

Evidence of coat color variation sheds new light on ancient canids. [PDF]

, 2013
International audienceWe have used a paleogenetics approach to investigate the genetic landscape of coat color variation in ancient Eurasian dog and wolf populations.
Arbogast, Rose-Marie, Balasescu, Adrian, Boroneant, Adina, Duffraisse, Marilyne, Gillet, Benjamin, Hitte, Christophe, Hughes, Sandrine, Hänni, Catherine, Lagoutte, Laetitia, Mashkour, Marjan, Ollivier, Morgane, Petit, Coraline, Pionnier-Capitan, Maud, Tresset, Anne, Vigne, Jean-Denis   +14 more
core   +5 more sources

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Functional variation of MC1R alleles from red-haired individuals [PDF]

Human Molecular Genetics, 2001
Red hair in humans is associated with variant alleles of the alphaMSH receptor gene, MC1R. Loss of MC1R function in other mammals results in red or yellow hair pigmentation. We show that a mouse bacterial artificial chromosome (BAC) which contains Mc1r will efficiently rescue loss of Mc1r in transgenic mice, and that overexpression of the receptor ...
Healy, Eugene, Jordan, Siobhán A., Budd, Peter S., Suffolk, Ruth, Rees, Jonathan L., Jackson, Ian J.   +5 more
openaire   +3 more sources

Influence of MC1R Gene Variants on Coat Color of Indicine Cattle Breeds

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT Indicine cattle display a broad range of coat colors, representing a relevant and breed‐defining trait required for registration in breeder association. Among the genes involved in pigmentation, MC1R stands out for modulating the synthesis of melanin‐related proteins and remains poorly explored in indicine cattle breeds. Therefore, we aimed to
Silel V. S. A. Maciel, Ingrid P. P. Oliveira, Beatriz B. Senes, Carolaine J. S. Santana, Jackeline S. Alves, Edilane A. da Silva, Fernando O. Franco, Bárbara C. F. da Silva, Fernando C. Cairo, Frederico C. Cairo, Aníbal E. Vercesi‐Filho, Raphael B. Costa, Gregório M. F. de Camargo   +12 more
wiley   +1 more source

Exterior characteristics and coat colour marker of MC1R gene in Bali Crossbred cattle

Journal of the Indonesian Tropical Animal Agriculture
Crossbreeding between Bali cattle with exotic bulls (such as Simmental and Limousin) has been widely developed in several regions in Indonesia. This study aims to determine changes in exterior characteristics and differences in vital statistics of Bali ...
G. M. Swasti, E. Wardana, H. Aditama, P. Panjono, T. Hartatik   +4 more
doaj   +1 more source

NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NF-κB pathway after intracerebral hemorrhage in mice

Journal of Neuroinflammation, 2019
Background Neuroinflammation and blood-brain barrier (BBB) disruption are two vital mechanisms of secondary brain injury following intracerebral hemorrhage (ICH).
Xuan Wu, Siming Fu, Yun Liu, Hansheng Luo, Feng Li, Yiying Wang, Meng Gao, Yuan Cheng, Zongyi Xie   +8 more
doaj   +1 more source

A melanocortin 1 receptor (MC1R) gene polymorphism is useful for authentication of Massese sheep dairy products [PDF]

, 2011
Massese is an Italian sheep breed, with black or grey coat colour, mainly reared in the Tuscany and Emilia Romagna regions. Recently, the emerging interests in this breed have resulted in the production of Pecorino cheese obtained with only Massese milk.
Beretti, F., Dall'Olio, S., Fontanesi, L., Matassino, D., Portolano, B., Russo, V.   +5 more
core   +1 more source

Global consensus on the management of melanin hyperpigmentation disorders

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 5, Page 760-772, May 2026.
A global Delphi consensus of 10 dermatology experts established evidence‐based recommendations for melanin hyperpigmentation disorders, providing unified classification, photoprotection guidance and treatment algorithms. This framework harmonizes terminology and supports individualized management across diverse skin types and health systems.
Thierry Passeron, Seemal R. Desai, Marwa Abdallah, Firas Al‐Niaimi, Ncoza Dlova, Pearl E. Grimes, Jorge Ocampo‐Candiani, Rashmi Sarkar, Leihong Flora Xiang, Helio Amante Miot   +9 more
wiley   +1 more source

Genome-Wide Association Study of Tanning Phenotype in a Population of European Ancestry [PDF]

, 1922
We conducted a multistage genome-wide association study (GWAS) of tanning response after exposure to sunlight in over 9,000 men and women of European ancestry who live in the United States.
Nan, Hongmei, Kraft, Peter, Qureshi, Abrar A., Guo, Qun, Chen, Constance, Hankinson, Susan E., Hu, Frank B., Thomas, Gilles, Hoover, Robert N., Chanock, Stephen, Hunter, David J., Han, Jiali   +11 more
core   +2 more sources

Haplotype‐Based Analysis of OCA2 Variants in Oculocutaneous Albinism

Pigment Cell &Melanoma Research, Volume 39, Issue 3, May 2026.
This study defines multi‐allele haplotypes, comprised of rare disease variants combined with common eQTL, sQTL and GWAS variants, for oculocutaneous albinism type 2 (OCA2). These haplotypes have implications for variant pathogenicity assessments and phenotypic variability.
Meredith F. Gillis, Madeleine R. Ames, Linnea Lundh, Valer Gotea, Laura Elnitski, Frank Donovan, NISC Comparative Sequencing Program, Adebowale Adeyemo, Charles Rotimi, Brian Brooks, Wadih Zein, William Gahl, William S. Oetting, David R. Adams, Stacie K. Loftus   +14 more
wiley   +1 more source