Results 101 to 110 of about 11,568 (220)
Polymorphisms in the Melanocortin-1 Receptor (Mc1R) Gene in Vitiligo
Balkan Medical Journal, 2012 Objective: Vitiligo is a progressive skin pigmentation disorder, which may be acquired or hereditary, frequently seen, and may influence every age group. The melanocortin 1 receptor (MC1R) gene is a major determinant of human pigmentation. In our study, polymorphic differences of the MC1R gene at the DNA level has been investigated in patients with ...
ACAR, Eylem +2 more
openaire +4 more sources
TET2 orchestrates YAP signaling to potentiate targetable vulnerability in hepatocellular carcinoma
Cell Death and DiseaseHepatocellular carcinoma (HCC) is a leading cause of global cancer-associated mortality. Although various therapies have substantially ameliorated clinical outcome, patients invariably suffer from cancer relapse, highlighting the need for more optimized ...
Jing He +14 more
doaj +1 more source
The Journal of Poultry Science, 2014 In contrast to other domestic and wild animals, the genetic variation of MC1R gene and association with plumage color has not been investigated in domestic goose.
Jing Huang +6 more
doaj +1 more source
Identification of MC1R SNPs and their Association with Plumage Colors in Asian Duck
The Journal of Poultry Science, 2017 The melanocortin 1 receptor (MC1R) gene is a candidate functional gene that controls the pigment production in melanocytes. The aim of this study was to identify polymorphisms and investigate the effect of the MC1R gene on plumage coloration in duck ...
Hasina Sultana +8 more
doaj +1 more source
Effect of MC1R functionality on the Formalin Response.
, 2013 Data represents the number of paw flinch or flick responses per min ± SEM following the intraplantar injection of formalin in [A] male and [B] female adult Mc1re, Tg-Mc1re, Ay-Jkn1and control non-Ay-Jkn1 mice (n = 5–9 per genotype).
Ian J. Jackson (215017) +3 more
core +1 more source
Electrophoretic analysis and intracellular stability of MC1R-TUBB3 isoforms.
, 2015 (A) Expression of canonical and chimeric MC1R proteins in heterologous HEK293T cells. HEK293T cells were transiently transfected to express Flag-labelled WT MC1R-001, Iso1 and Iso2. Cells were detergent-solubilized, electrophoresed and blotted.
Celia Jiménez-Cervantes (836701) +5 more
core +1 more source
The melanocortin receptors and their accessory proteins. [PDF]
, 2013 The five melanocortin receptors (MCRs) named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behavior as well as exocrine function.
Adrian J. L. Clark +12 more
core +1 more source
Frontiers in Genetics, 2019 Melanocortin 1 receptor (MC1R), the agouti signaling protein (ASIP), and tyrosinase related protein 1 (TYRP1) are among the major regulators of pigmentation in mammals.
Fahad Alshanbari +7 more
doaj +1 more source
(CKPV)2 promotes cAMP production via MC1R.
, 2013 (A) Upper panel: the effects of MC1R siRNA (S1, S2 and S3, see sequence on Tab. 1) on MC1R mRNA level in primary cultured macrophages. Lower panel: MC1R siRNA knockdown almost blocked (CKPV)2-induced cAMP production in macrophages.
Xiang-rong Dai (282203) +16 more
core +1 more source
MC1R alignment_Fulgione et al. 2016.fasta
, 2016 MC1R sequences of pregnant wild boar samples ...
Trapanese, Martina +11 more
core +1 more source