Results 111 to 120 of about 11,568 (220)
The Role of MC1R in Speciation & Phylogeny
The American Biology Teacher, 2013 A point mutation in the MC1R gene, a G-protein-coupled receptor, has been found that could have led to the formation of two subspecies of Solomon Island flycatcher from a single ancestral population. I discuss the many roles that G-protein-coupled receptors play in vertebrate physiology and how one particular point mutation can have enormous ...
openaire +1 more source
Neuropsychiatric Disease and Treatment, 2021 Yue Wu,1,* Jiajun Yin,2,* Bixiu Yang,3 Li Tang,4 Wei Feng,5 Xiaowei Liu,1 Xingfu Zhao,1 Zaohuo Cheng1 1Department of Geriatric Psychiatry, The Affiliated Wuxi Mental Health Center with Nanjing Medical University, Wuxi, Jiangsu Province, People’s ...
Wu Y +7 more
doaj
, 2010 Individuals with red hair and fair skin due to MC1R gene variants are at higher risk of cutaneous neoplasia, consistent with MC1R having a role in photoprotection.
Friedmann, Peter S. +7 more
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MC1R and NR4A receptors in cellular stress and DNA repair: implications for UVR protection
, 2014 Ultraviolet radiation (UVR) is the most common mutagen which melanocytes are exposed to. UVR causes a diverse range of DNA photolesions contributing to genome instability and promotes melanoma and non-melanoma development.
Aaron G. Smith +5 more
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Germline MC1R Variants and BRAF Mutant Melanoma
, 2008 Recent studies have demonstrated that melanocortin-1 receptor (MC1R) variants increase the risk of melanomas harboring BRAF mutations. This finding provides insight into the relationship between host genotype and selection for somatic mutation type ...
Hacker, Elke +3 more
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Melanocortin-1 receptor (MC1R) expression in Caco-2 cells.
, 2017 Cells were grown into confluent monolayers for 21 days on culture inserts and immunostained for MC1R. Nuclei were labeled with propidium iodide. Optical sections prepared by a confocal microscope show MC1R expression levels at the apical and basal ...
András Harazin (3567704) +13 more
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Molecular mechanism of MC1R association with skin cancer risk phenotypes
, 2008 The melanocortin-1 receptor (MC1R) is a G-protein coupled receptor (GPCR) expressed on the surface of the melanocyte. MC1R activation after UV exposure results in the production of the dark eumelanin pigment and the tanning process in humans, providing ...
Ms Kimberley Beaumont
core
Is the MC1R variant p.R160W associated with Parkinson's? [PDF]
Annals of Neurology, 2015 Steven J, Lubbe +11 more
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Confirmation of the role of Mc1r on cell migration using an in vivo metastasis model.
, 2012 (A, B) Effect of Mc1r knockdown on the development of pulmonary metastatic colony was determined. B16F10 melanoma cells were treated with MT1-Mc1r (A) or WT1-Mc1r (B) and injected into tail vein of C57BL/6 mice.
Jung-Hyun Lee (181962) +7 more
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