Results 121 to 130 of about 11,568 (220)
Role of Mc1r in UV-Induced Melanoma in Animal Models
Journal of Carcinogenesis & Mutagenesis, 2014 The role of UV and pigmentation are very difficult to control for in human studies, and mechanisms difficult to infer based on statistical association with melanoma. The animal models are not representative of the human situation. But on the other hand, animal studies can be useful for basic studies that will ultimately help in building up a picture of
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Functional variation of MC1R alleles from red-haired individuals
, 2001 Red hair in humans is associated with variant alleles of the MSH receptor gene, MC1R. Loss of MC1R function in other mammals results in red or yellow hair pigmentation.
Jackson, Ian J. +5 more
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Evidence for variable selective pressures at MC1R
It is widely assumed that genes that influence variation in skin and hair pigmentation are under selection. To date, the melanocortin 1 receptor (MC1R) is the only gene identified that explains substantial phenotypic variance in human pigmentation.
Healy E; Todd C; Ray AJ; Flanagan N; Birch-Machin MA; Rees JL; Harding RM; Ellis NS; Dixon C; Sajantila A; Jackson IJ
core
, 2012 Mc1r haplotype neighbor joining tree with the 66 identified haplotypes. Haplotypes are associated with lizards whose dorsal coloration is either light, dark, or both (dark/light).
Eric J. Routman (125449) +2 more
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Radioligand binding and intracellular trafficking properties of MC1R-TUBB3 isoforms.
, 2015 (A-B) Competition binding assay of HEK293T cells transfected with MC1R-001, Iso1 and Iso2. Cells were incubated with 125I-labelled NDP-MSH (5x10-11 M) and increasing concentrations of non-labelled competing NDP-MSH, from 10−12 to 10−7 M, extensively ...
Celia Jiménez-Cervantes (836701) +5 more
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Analysi of MC1R polymorphism in Sardo-Modicana cattle
, 2009 Coat colour has been a topic of interest for both breeders and geneticists. Currently most cattle breeds are identified by their coat colour. In mammals, red/yellow and black/brown colours are determined by the distribution of two pigments: pheomelanin and eumelanin.
Rassu, Salvatore Pier Giacomo +4 more
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MC1R Expression in Skin: Is it Confined to Melanocytes? [PDF]
Journal of Investigative Dermatology, 2007 Roberts, Donald W. +2 more
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Ultrarapid MC1R protein and associated plumage color evolution in the domestic chicken. [PDF]
Proc Natl Acad Sci U S AMa C +10 more
europepmc +1 more source