Results 71 to 80 of about 11,568 (220)

BRAF and MC1R in Melanoma: Different in Head and Neck Tumors? [PDF]

Journal of Investigative Dermatology, 2013
In this issue, Hacker et al. (2012) report the largest study to date on the association between MC1R variants and BRAF mutant melanoma. Although they did not observe a significant overall correlation, there was a significant negative association between BRAF and MC1R mutations for head/neck melanomas.
Fink, Emma C., Fisher, David E.
openaire   +2 more sources

Microbial Metabolite‐Stimulated Bitter Taste Receptor T2R14 Signaling Is Modulated by CFTR Interactions

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Bitter taste receptors (T2Rs) play an important role in physiological and cellular responses. Bitter tasting chemicals and microbial metabolites can bind to T2R14, which enables interactions between T2R14 and specific intracellular domains of the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel.
Tejas Gupte, Nisha Singh, Vikram Bhatia, Kavisha Arora, Shayan Amiri, Paul Fernyhough, Anjaparavanda P. Naren, Shyamala Dakshinamurti, Prashen Chelikani   +8 more
wiley   +1 more source

Activation of the melanocortin-1 receptor attenuates neuronal apoptosis after traumatic brain injury by upregulating Merlin expression

Brain Research Bulletin
Traumatic brain injury (TBI) is a common disease worldwide with high mortality and disability rates. Besides the primary mechanical injury, the secondary injury associated with TBI can also induce numerous pathological changes, such as brain edema, nerve
Jinqi Lu, Jin Wang, Haibo Ni, Bing Li, Jingjing Yang, Jie Zhu, Jie Qian, Rong Gao, Rong Xu   +8 more
doaj   +1 more source

NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NF-κB pathway after intracerebral hemorrhage in mice

Journal of Neuroinflammation, 2019
Background Neuroinflammation and blood-brain barrier (BBB) disruption are two vital mechanisms of secondary brain injury following intracerebral hemorrhage (ICH).
Xuan Wu, Siming Fu, Yun Liu, Hansheng Luo, Feng Li, Yiying Wang, Meng Gao, Yuan Cheng, Zongyi Xie   +8 more
doaj   +1 more source

MC1R Is a potent regulator of PTEN after UV exposure in melanocytes

, 2013
The individuals carrying melanocortin-1 receptor (MC1R) variants, especially those associated with red hair color, fair skin, and poor tanning ability (RHC trait), are more prone to melanoma; however, the underlying mechanism is poorly defined.
Ken Dutton-Regester, Juxiang Cao, Goding, CR, Xiangpeng Dai, Rutao Cui, Cui, R, Yongjun Wang, Goding, Colin R., Hacker, E, Wan, Lixin, Widlund, Hans, Stefania Lenna, Hayward, NK, Rhoda M. Alani, Dai, Xiangpeng, Xu, GX, Colin R. Goding, Dutton-Regester, K, Goding, Colin, Hans R. Widlund, Celia Jimenez-Cervantes, Wei, Wenyi, Cui, Rutao, Widlund, HR, Hayward, Nicholas, Wenyi Wei, Wang, Yongjun, Leslie, Nick R; id_orcid, Alani, Rhonda, Leslie, Nick, Widlund, Hans R., Alani, Rhoda M., Alani, RM, Lenna, Stefania, Xu, George X., Cao, J, Cao, Juxiang, Leslie, NR, Wang, Y, Ryu, Byungwoo, Lixin Wan, Dai, X, Lenna, S, Nick R. Leslie, Wan, L, Ryu, B, Jimenez-Cervantes, Celia, George X. Xu, Jimenez-Cervantes, C, Hacker, Elke, Nicholas K. Hayward, Elke Hacker, Dutton-Regester, Ken, Hayward, Nicholas K., Xu, George, Byungwoo Ryu, Wei, W, Jimenez-Carvantes, Celia   +57 more
core   +1 more source

Exterior characteristics and coat colour marker of MC1R gene in Bali Crossbred cattle

Journal of the Indonesian Tropical Animal Agriculture
Crossbreeding between Bali cattle with exotic bulls (such as Simmental and Limousin) has been widely developed in several regions in Indonesia. This study aims to determine changes in exterior characteristics and differences in vital statistics of Bali ...
G. M. Swasti, E. Wardana, H. Aditama, P. Panjono, T. Hartatik   +4 more
doaj   +1 more source

ASIP Variants in Livestock: It's Not Black and White

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT Fur and feather pigmentation play an important role in the survival and reproduction of many species, as well as in selective breeding and agriculture. The synthesis of pigment molecules, eumelanin and pheomelanin, is partially regulated by the agouti signalling protein (ASIP) encoded by the ASIP gene.
Isabella M. Brown, Kylie A. Munyard
wiley   +1 more source

Melanocortin 1 receptor mediates melanin production by interacting with the BBSome in primary cilia.

PLoS Biology
Production of melanin pigments is a protective mechanism of the skin against ultraviolet (UV)-induced damage and carcinogenesis. However, the molecular basis for melanogenesis is still poorly understood.
Xiaoyu Tian, Hanyu Wang, Song Liu, Wei Liu, Kaiyue Zhang, Xiaohan Gao, Qingchao Li, Huijie Zhao, Liangran Zhang, Peiwei Liu, Min Liu, Youjun Wang, Xueliang Zhu, Rutao Cui, Jun Zhou   +14 more
doaj   +1 more source

A Novel Pale-Yellow Coat Color of Rabbits Generated viaMC1R Mutation With CRISPR/Cas9 System

Frontiers in Genetics, 2019
Coat color is of great importance in animal breed characteristics; it is not only a significant productive trait but also an indispensable economic trait, especially in the rabbit industry.
Ning Xiao, Hongli Li, Laiba Shafique, Shanshan Zhao, Xiaoping Su, Yu Zhang, Kuiqing Cui, Qingyou Liu, Deshun Shi   +8 more
doaj   +1 more source

In Vivo and In Vitro Evaluation of PTeCA (1H‐Pyrrole‐2,3,4,5‐Tetracarboxylic Acid) in Hair Matrix as a Marker for Oxidative Cosmetic Treatment

Drug Testing and Analysis, Volume 18, Issue 6, Page 739-749, June 2026.
A total of 3378 self‐reported treated and untreated hair samples were analyzed for PTCA and PTeCA by LC‐MS/MS. Moreover, their in vitro formation was assessed in 225 untreated hair by different cosmetic treatments with and without oxidative agents. Data suggest that PTeCA could be a reliable marker for oxidative cosmetic treatments in hair.
Sara Casati, Alessandro Ravelli, Roberta F. Bergamaschi, Agata Magliocco, Sofia Vanerio, Gabriella Roda, Paola Rota, Marica Orioli, Alessio Battistini   +8 more
wiley   +1 more source