Results 51 to 60 of about 11,568 (220)

The use of MC1R and KIT genotypes for breed characterisation.

, 2003
We describe the characterisation of the two main coat colour determining loci (MC1R and KIT) for pigs and demonstrate how this information can be utilized for breed identification.
Mitsuhashi, T., Carrion, D., Archibald, A., Day, A., Evans, G., Andersson, L., Plastow, G., Haley, C.   +7 more
core   +1 more source

Effectiveness and Safety of Setmelanotide in a Patient With a Heterozygous PCSK1 Deficiency

Obesity, EarlyView.
ABSTRACT Setmelanotide, a melanocortin 4 receptor (MC4R) agonist, is a promising pharmacological treatment option for people with rare monogenic obesity conditions affecting the leptin‐melanocortin signaling pathway, including proprotein convertase subtilisin/kexin type 1 (PCSK1) gene mutations.
Ellina Lytvyak, Arshdeep Rattol, Eduardo Grunvald   +2 more
wiley   +1 more source

Palmitoylation-dependent activation of MC1R prevents melanomagenesis

, 2018
The melanocortin-1 receptor (MC1R), a G protein-coupled receptor, plays a crucial role in human and mouse pigmentation1–8. Activation of MC1R in melanocytes by α-melanocyte-stimulating hormone (α-MSH)9 stimulates cAMP signaling and melanin production and
Liu, Tongzheng, Hu, Limin, Li, Chunying, Zhou, Jun, Xu, Zhi-Xiang, Liu, Wei, Zhu, Bo, Gao, Xiumei, Li, Xin, Chen, Xiang, Chen, Shuyang, Yin, Chengqian, Wu, Xu, Han, Changpeng, Cui, Rutao, Goding, Colin R., Chen, Baoen   +16 more
core   +1 more source

MC1R signaling. Intracellular partners and pathophysiological implications

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017
The melanocortin-1 receptor (MC1R) preferentially expressed in melanocytes is best known as a key regulator of the synthesis of epidermal melanin pigments. Its paracrine stimulation by keratinocyte-derived melanocortins also activates DNA repair pathways and antioxidant defenses to build a complex, multifaceted photoprotective response.
Cecilia, Herraiz, Jose C, Garcia-Borron, Celia, Jiménez-Cervantes, Conchi, Olivares   +3 more
openaire   +2 more sources

MODELLING OF 3D-STRUCTURES OF THE RARE MELANOCORTIN-1-RECEPTOR MUTATIONS ASSOCIATED TO MELANISM IN THE BANANAQUIT

Acta Biológica Colombiana, 2020
Melanism in plumage color is often associated to the single nucleotide polymorphism of the melanocortin-1-receptor (MC1R). Despite the striking association between the substitution of a Glutamic-acid by for a Lysine at position 92 on the MC1R protein and
Raúl Ernesto Sedano-Cruz, Daniel Camilo Osorio   +1 more
doaj   +1 more source

Comparative Molecular Insights into Developmental and Behavioral Toxicity Induced by Octocrylene and Ethylhexyl Salicylate Exposure on Zebrafish

Integrative Zoology, EarlyView.
This study compared the ecological toxicity of organic ultraviolet filters, octocrylene (OC) and ethylhexyl salicylate (EHS), on zebrafish embryos and larvae. EHS exhibited higher acute toxicity, causing increased mortality, hypoactive behavior at 50 mg/L, and disruptions in lipid homeostasis, while OC primarily affected hypoxia response and ...
Xiaoyang Lu, Li Sun, Jiao Chen, Jing Wang, Miao Guan, Shixia Xu   +5 more
wiley   +1 more source

Melanocortin 1 Receptor (MC1R): Pharmacological and Therapeutic Aspects

, 2023
Melanocortins play crucial roles in regulating the stress response, inflammation, and skin pigmentation. In this review, we focus on the melanocortin 1 receptor (MC1R), a G protein-coupled receptor primarily known for regulating skin pigmentation and ...
Yoonwoo Mun, Dongyun Shin, Woohyun Kim
core   +1 more source

MC1R depalmitoylation inhibition reveals a physiological role for pheomelanin. [PDF]

PNAS Nexus
Abstract Pheomelanin is a sulfur-containing pigment produced by melanocytes notably in individuals with red hair/fair skin and animals with orange integumentary structures. Pheomelanin is not photoprotective as the dark eumelanin, but is cytotoxic, being related to a high risk of melanoma independently of UV radiation.
Galván I, García-Guerra M, Araujo-Roque M.   +2 more
europepmc   +3 more sources

Age‐specific melanoma risk associated with nevi: a pooled analysis from the M‐SKIP project

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Objective This study investigates the association of melanoma risk with total‐body nevus count and the presence of atypical nevi in younger (< 40 years) and older (> 60 years) individuals. Methods A pooled analysis was conducted within the M‐SKIP project, based on multiple melanoma case‐control studies.
Giulia Doi, Aurora Gaeta, Simone Ribero, Nelleke Gruis, Julia Newton‐Bishop, David Polsky, DeAnn Lazovich, Paola Ghiorzo, Gloria Ribas, Chiara Menin, Alexander J. Stratigos, Gabriella Guida, Susana Puig, Maria Concetta Fargnoli, Peter A. Kanetsky, Paola Queirolo, Vincenzo Bagnardi, Veronique Bataille, Sara Raimondi, Sara Gandini, M‐SKIP study group   +20 more
wiley   +1 more source

Mc1r promotes migration of melanoma cells.

, 2012
(A) Quantitative Real time RTPCR assays were carried out using B16F10 murine melanoma cells transfected with the universal control siRNA, MT1-Mc1r, or one of the three siRNAs specific for Mc1r, WT1-Mc1r, WT2-Mc1r, and WT3-Mc1r. The nucleotide sequence of
Jung-Hyun Lee (181962), Chang-Yeol Yeo (181967), Jaesang Kim (181982), Hyun Jung Min (181957), Eok-Soo Oh (181975), Dong Min Kang (181970), Ikjoo Seong (181949), Eun Sook Hwang (181978)   +7 more
core   +1 more source