Results 11 to 20 of about 9,263 (182)

Influence of MC1R Gene Variants on Coat Color of Indicine Cattle Breeds. [PDF]

Anim Genet
ABSTRACT Indicine cattle display a broad range of coat colors, representing a relevant and breed‐defining trait required for registration in breeder association. Among the genes involved in pigmentation, MC1R stands out for modulating the synthesis of melanin‐related proteins and remains poorly explored in indicine cattle breeds. Therefore, we aimed to
Maciel SVSA, Oliveira IPP, Senes BB, Santana CJS, Alves JS, da Silva EA, Franco FO, da Silva BCF, Cairo FC, Cairo FC, Vercesi-Filho AE, Costa RB, de Camargo GMF.   +12 more
europepmc   +2 more sources

Effect of polymorphisms in the 5’-flanking sequence of MC1R on feather color in Taihang chickens

Poultry Science, 2022
: MC1R plays an important role in the regulation of the formation, transfer, and deposition of melanin in animals and is important for determining coat color.
Yekai Fan, Xianwen Wu, Yamin Li, Haiyin Han, Yifan Zhang, Junqi Yang, Yufang Liu   +6 more
doaj   +1 more source

Role of MC1R variants in uveal melanoma [PDF]

British Journal of Cancer, 2003
Variants of the melanocortin-1 receptor (MC1R) gene have been linked to sun-sensitive skin types and hair colour, and may independently play a role in susceptibility to cutaneous melanoma. To assess the role of MC1R variants in uveal melanoma, we have analysed a cohort of 350 patients for the changes within the major region of the gene displaying ...
Hearle, N, Humphreys, J, Damato, BE, Wort, R, Talaban, R, Wixey, J, Green, H, Easton, DF, Houlston, RS   +8 more
openaire   +6 more sources

MC1R Functions, Expression, and Implications for Targeted Therapy

Journal of Investigative Dermatology, 2022
The G protein-coupled MC1R is expressed in melanocytes and has a pivotal role in human skin pigmentation, with reduced function in human genetic variants exhibiting a red hair phenotype and increased melanoma predisposition. Beyond its role in pigmentation, MC1R is increasingly recognized as promoting UV-induced DNA damage repair.
Stefania Guida, Gabriella Guida, Colin Ronald Goding   +2 more
openaire   +3 more sources

Single‐cell profiling of MC1R‐inhibited melanocytes

Pigment Cell & Melanoma Research, 2023
AbstractThe human red hair color (RHC) trait is caused by increased pheomelanin (red‐yellow) and reduced eumelanin (black‐brown) pigment in skin and hair due to diminished melanocortin 1 receptor (MC1R) function. In addition, individuals harboring the RHC trait are predisposed to melanoma development.
Berns, H. Matthew, Watkins‐Chow, Dawn E., Lu, Sizhu, Louphrasitthiphol, Pakavarin, Zhang, Tongwu, Brown, Kevin M., Moura‐Alves, Pedro, Goding, Colin R., Pavan, William J.   +8 more
openaire   +3 more sources

Inherited variation at MC1R and histological characteristics of primary melanoma. [PDF]

PLoS ONE, 2015
Variation in the melanocortin-1receptor (MC1R) gene is associated with pigmentary phenotypes and risk of malignant melanoma. Few studies have reported on MC1R variation with respect to tumor characteristics, especially clinically important prognostic ...
Nicholas J Taylor, Klaus J Busam, Lynn From, Pamela A Groben, Hoda Anton-Culver, Anne E Cust, Colin B Begg, Terence Dwyer, Richard P Gallagher, Stephen B Gruber, Irene Orlow, Stefano Rosso, Nancy E Thomas, Roberto Zanetti, Timothy R Rebbeck, Marianne Berwick, Peter A Kanetsky   +16 more
doaj   +1 more source

Polymorphic loci of coat color in mini-pigs

Вавиловский журнал генетики и селекции, 2016
The present work is phenomenological and purely descriptive. It shows polymorphism of colors in a breeding group of mini-pig in the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences (ICG SB RAS) and makes some ...
S. V. Nikitin, K. S. Shatokhin, S. P. Knyazev, G. M. Goncharenko, V. I. Zaporozhets, V. I. Ermolayev   +5 more
doaj   +1 more source

Discriminant analysis of colour measurements reveals allele dosage effect of ASIP/MC1R in bay horses

Czech Journal of Animal Science, 2018
Considering the variability of bay coat colour, we aimed to investigate the association of different shades of bay with ASIP and MC1R genotype combinations and we studied the discrimination between the bay and black coat colour.
Thomas Druml, Gertrud Grilz-Seger, Michaela Horna, Gottfried Brem   +3 more
doaj   +1 more source

Phenotypic and Genetic Features that Differ Between Hereditary and Sporadic Melanoma: Results of a Preliminary Study from a Single Center from Turkey

Dermatology Practical & Conceptual, 2023
Introduction: We have observed that most cutaneous melanoma patients under our supervision lack characteristic phenotypical features for melanoma. In contrast; history of cancers other than melanoma and age at onset before 50 were common.
Aysel Çakır, Gonca Elcin, Saadettin Kilickap, Özay Gököz, Zihni Ekim Taskiran, İsmail Celik   +5 more
doaj   +1 more source

Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity

Nature Communications, 2023
Inhibition of T cell infiltration dampens antitumor immunity and causes resistance to immune checkpoint blockade (ICB) therapy. By in vivo CRISPR screening in B16F10 melanoma in female mice, here we report that loss of melanocortin-1 receptor (MC1R) in ...
Yazhong Cui, Yang Miao, Longzhi Cao, Lifang Guo, Yue Cui, Chuanzhe Yan, Zhi Zeng, Mo Xu, Ting Han   +8 more
doaj   +1 more source