Results 11 to 20 of about 11,568 (220)

Evidence for variable selective pressures at MC1R [PDF]

The American Journal of Human Genetics, 2000
It is widely assumed that genes that influence variation in skin and hair pigmentation are under selection. To date, the melanocortin 1 receptor (MC1R) is the only gene identified that explains substantial phenotypic variance in human pigmentation.
Flanagan, Niamh, Dixon, Craig, Harding, Rosalind M., Sajantila, Antti, Jackson, Ian, Ray, Amanda, Rees, Jonathan, Ellis, N. S., Todd, Carole, Healy, Eugene, Birch-Machin, Mark A   +10 more
core   +7 more sources

MC1R functions, expression and implications for targeted therapy

Journal of Investigative Dermatology, 2021
The G protein-coupled MC1R is expressed in melanocytes and has a pivotal role in human skin pigmentation, with reduced function in human genetic variants exhibiting a red hair phenotype and increased melanoma predisposition.
Gabriella Guida, Colin Goding, Guida, Gabriella, Guida, Stefania, Guida S., Goding C. R., Stefania Guida, Guida G., Goding, Colin   +8 more
core   +4 more sources

Palmitoylation-dependent activation of MC1R prevents melanomagenesis [PDF]

Nature, 2017
The melanocortin-1 receptor (MC1R), a G protein-coupled receptor, plays a crucial role in human and mouse pigmentation. Activation of MC1R in melanocytes by α-melanocyte-stimulating hormone (α-MSH) stimulates cAMP signaling and melanin production and ...
Shuyang Chen, Chunying Li, Xin Li, Zhu, B, Liu, T, Changpeng Han, Tongzheng Liu, Liu, W, Yin, C, Chen, S, Chen, X, Li, C, Rutao Cui, Cui, R, Xiumei Gao, Zhou, J, Wu, X, Limin Hu, Chen, B, Han, C, Chengqian Yin, Jun Zhou, Colin R. Goding, Hu, L, Xu Wu, Goding, Colin, Xiang Chen, Xu, Z-X, Baoen Chen, Li, X, Zhi-Xiang Xu, Wei Liu, Gao, X, Bo Zhu, Goding, C   +34 more
core   +6 more sources

Role of MC1R variants in uveal melanoma [PDF]

British Journal of Cancer, 2003
Variants of the melanocortin-1 receptor (MC1R) gene have been linked to sun-sensitive skin types and hair colour, and may independently play a role in susceptibility to cutaneous melanoma.
Green, H, D F Easton, Damato, B. E., Talaban, R., J Wixey, Wort, R, J Humphreys, Hearle, N, B E Damato, Damato, BE, Wixey, J., R Wort, Wort, R., Wixey, J, N Hearle, Houlston, RS, Houlston, R. S., Humphreys, J., R S Houlston, Green, H., H Green, Easton, DF, Hearle, N., Talaban, R, Humphreys, J, Easton, D. F., R Talaban   +26 more
core   +7 more sources

MC1R Variation in a New Mexico Population [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2019
Background: The Melanocortin 1 Receptor (MC1R) contributes to pigmentation, an important risk factor for developing melanoma. Evaluating SNPs in MC1R and association with race/ethnicity, skin type, and perceived cancer risk in a New Mexico (NM ...
Hunley, Keith, Robers, Erika, Zielaskowski, Kate, Hay, Jennifer L, Kaphingst, Kimberly A, Guest, Dolores D, Hughes, Christopher R, Sussman, Andrew, Schwartz, Matthew R, Berwick, Merianne, White, Kirsten A.M, Buller, David B, Dailey, Yvonne T   +12 more
core   +3 more sources

Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads [PDF]

Nature Communications, 2019
Some genetic melanocortin-1 receptor (MC1R) variants responsible for human red hair color (RHC-variants) are consequently associated with increased melanoma risk.
et al.,, al., et, Chen, S, Han, C, Goding, C, Goding, Colin   +5 more
core   +5 more sources

Single-cell profiling of MC1R-inhibited melanocytes

Pigment Cell & Melanoma Research, 2023
The human red hair color (RHC) trait is caused by increased pheomelanin (red-yellow) and reduced eumelanin (black-brown) pigment in skin and hair due to diminished melanocortin 1 receptor (MC1R) function.
Brown, Kevin M, Goding, Colin R, Watkins-Chow, Dawn E, Berns, H Matthew, Lu, Sizhu, Louphrasitthiphol, Pakavarin, Zhang, Tongwu, Pavan, William J, Moura-Alves, Pedro   +8 more
core   +4 more sources

Melanocortin-1 receptor (MC1R): a review for dermatologists

Italian Journal of Dermatology and Venereology
Melanocortin-1 receptor (MC1R) and its variants have a pivotal role in melanin synthesis. However, MC1R has been associated to non-pigmen- tary pathways related to DNA-repair activities and inflammation. The aim of this review is to provide an up-to-date
Susana PUIG, Stefania GUIDA, Chiara DI RESTA, Franco RONGIOLETTI, Gabriella GUIDA, Mangano, Eleonora, Sallustio, Fabio, Stabile, Giorgio, Rongioletti, Franco, Giorgio STABILE, Giovanni PELLACANI, Longo, Caterina, Puig, Susana, Caterina LONGO, DI Resta, Chiara, Guida, Gabriella, Guida, Stefania, Eleonora MANGANO, Fabio SALLUSTIO, Pellacani, Giovanni   +19 more
core   +6 more sources

The MC1R Gene and Youthful Looks [PDF]

Current Biology, 2016
Looking young for one's age has been a desire since time immemorial. This desire is attributable to the belief that appearance reflects health and fecundity. Indeed, perceived age predicts survival [1] and associates with molecular markers of aging such as telomere length [2]. Understanding the underlying molecular biology of perceived age is vital for
Liu, F., Hamer, M.A., Deelen, J., Lall, J.S., Jacobs, L., Heemst, D. van, Murray, P.G., Wollstein, A., Craen, A.J.M. de, Uh, H.W., Zeng, C.Q., Hofman, A., Uitterlinden, A.G., Houwing-Duistermaat, J.J., Pardo, L.M., Beekman, M., Slagboom, P.E., Nijsten, T., Kayser, M., Gunn, D.A.   +19 more
openaire   +5 more sources

Molecular Marker-Assisted Selection of Green Shank and White Feather Traits in Chickens

Guangdong nongye kexue, 2023
【Objective】The shank and feather color, as the characteristic traits of breeds, which remains an important selective trait in the breeding process of new varieties.
Xuewen CHAI, Jishang GONG, Fangfang CUI, Zhaofeng KANG, Yanping WU, Min ZHOU, Xuemei SUN, Jiguo XU   +7 more
doaj   +1 more source