Results 11 to 20 of about 16,448 (221)

Associations of MC1R Substitutions With Body Color Variation in a Desert Lizard

Ecology and Evolution
Body color variation is widespread among animals, and the melanocortin 1 receptor (MC1R) acts as a vital switch gene in regulating pigmentation. A small number of amino acid substitutions, or even a single one, in MC1R are known to influence the body ...
Haojie Tong, Qianjin Lin, Shuangyue Shi, Kaixin Wang, Yaxin Guo, Richard P. Brown, Yuanting Jin   +6 more
doaj   +2 more sources

Germline MC1R status influences somatic mutation burden in melanoma [PDF]

Nature Communications, 2016
The major genetic determinants of cutaneous melanoma risk in the general population are disruptive variants (R alleles) in the melanocortin 1 receptor (MC1R) gene.
A Ozola, A Yates, C Wilks, CM Olsen, D Mitra, DL Duffy, DT Bishop, E Healy, E Hodis, E Pasquali, ED Pleasance, H Ikehata, I Adzhubei, J Cao, JA Newton-Bishop, JC García-Borrón, JE Hauser, JJ Latimer, JR Davies, JS Más, K Cibulskis, K Jagirdar, KA Beaumont, KA Beaumont, L Denat, LB Alexandrov, M Krauthammer, M Krauthammer, MF Berger, P Shriber, P Valverde, PB Cassidy, PC Ng, PF Williams, RA Sturm, S Raimondi, S van Buuren, SA Forbes, SG Jarrett, SG Jarrett, T Dwyer, TH Nasti, V Swope, YW Teh, Z Zhang, ZA Abdel-Malek   +45 more
core   +6 more sources

Single‐cell profiling of MC1R‐inhibited melanocytes

Pigment Cell & Melanoma Research, 2023
AbstractThe human red hair color (RHC) trait is caused by increased pheomelanin (red‐yellow) and reduced eumelanin (black‐brown) pigment in skin and hair due to diminished melanocortin 1 receptor (MC1R) function. In addition, individuals harboring the RHC trait are predisposed to melanoma development.
Berns, H. Matthew, Watkins‐Chow, Dawn E., Lu, Sizhu, Louphrasitthiphol, Pakavarin, Zhang, Tongwu, Brown, Kevin M., Moura‐Alves, Pedro, Goding, Colin R., Pavan, William J.   +8 more
openaire   +3 more sources

The MC1R Gene and Youthful Looks [PDF]

Current Biology, 2016
Looking young for one's age has been a desire since time immemorial. This desire is attributable to the belief that appearance reflects health and fecundity. Indeed, perceived age predicts survival [1] and associates with molecular markers of aging such as telomere length [2]. Understanding the underlying molecular biology of perceived age is vital for
Liu, F., Hamer, M.A., Deelen, J., Lall, J.S., Jacobs, L., Heemst, D. van, Murray, P.G., Wollstein, A., Craen, A.J.M. de, Uh, H.W., Zeng, C.Q., Hofman, A., Uitterlinden, A.G., Houwing-Duistermaat, J.J., Pardo, L.M., Beekman, M., Slagboom, P.E., Nijsten, T., Kayser, M., Gunn, D.A.   +19 more
openaire   +5 more sources

The ASIP Cys-98 Allele Is Not Associated With Black Coat Color in Water Buffaloes. [PDF]

Anim Genet
Animal Genetics, Volume 57, Issue 2, April 2026.
de Moraes JVS, Maciel SVSA, Oliveira IPP, Senes BB, Alves JS, Costa RB, de Camargo GMF.   +6 more
europepmc   +2 more sources

Role of MC1R variants in uveal melanoma [PDF]

British Journal of Cancer, 2003
Variants of the melanocortin-1 receptor (MC1R) gene have been linked to sun-sensitive skin types and hair colour, and may independently play a role in susceptibility to cutaneous melanoma. To assess the role of MC1R variants in uveal melanoma, we have analysed a cohort of 350 patients for the changes within the major region of the gene displaying ...
Hearle, N, Humphreys, J, Damato, BE, Wort, R, Talaban, R, Wixey, J, Green, H, Easton, DF, Houlston, RS   +8 more
openaire   +4 more sources

MC1R Functions, Expression, and Implications for Targeted Therapy

Journal of Investigative Dermatology, 2022
The G protein-coupled MC1R is expressed in melanocytes and has a pivotal role in human skin pigmentation, with reduced function in human genetic variants exhibiting a red hair phenotype and increased melanoma predisposition. Beyond its role in pigmentation, MC1R is increasingly recognized as promoting UV-induced DNA damage repair.
Stefania Guida, Gabriella Guida, Colin Ronald Goding   +2 more
openaire   +3 more sources

Melanocortin 1 receptor targeted imaging of melanoma with gold nanocages and positron emission tomography [PDF]

, 2018
Purpose: Melanoma is a lethal skin cancer with unmet clinical needs for targeted imaging and therapy. Nanoscale materials conjugated with targeting components have shown great potential to improve tumor delivery efficiency while minimizing undesirable ...
Black, Kvar, Detering, Lisa, Liu, Yongjian, Luehmann, Hannah, Pang, Bo, Sultan, Deborah, Xia, Younan, Yang, Miaoxin, Zhao, Yongfeng   +8 more
core   +2 more sources

The melanocortin receptors and their accessory proteins. [PDF]

, 2013
The five melanocortin receptors (MCRs) named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behavior as well as exocrine function.
Chan, LF, Clark, AJ, Gorrigan, RJ, Ramachandrappa, S   +3 more
core   +2 more sources

Inherited variation at MC1R and histological characteristics of primary melanoma. [PDF]

PLoS ONE, 2015
Variation in the melanocortin-1receptor (MC1R) gene is associated with pigmentary phenotypes and risk of malignant melanoma. Few studies have reported on MC1R variation with respect to tumor characteristics, especially clinically important prognostic ...
Nicholas J Taylor, Klaus J Busam, Lynn From, Pamela A Groben, Hoda Anton-Culver, Anne E Cust, Colin B Begg, Terence Dwyer, Richard P Gallagher, Stephen B Gruber, Irene Orlow, Stefano Rosso, Nancy E Thomas, Roberto Zanetti, Timothy R Rebbeck, Marianne Berwick, Peter A Kanetsky   +16 more
doaj   +1 more source