Results 71 to 80 of about 182,632 (352)

Asparagine in Blood Plasma [PDF]

Nature, 1953
FREE asparagine has twice before been reported in animal tissues, namely, in the liver, kidney and spleen of sheep1, and, recently, in human urine2. The evidence given below shows that it is also present in the blood plasma of both man and the goat: the concentrations are, in fact, comparable to those of many other free amino-acids in blood plasma.
openaire   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Extracellular Vesicle‐Packaged Linc‐ZNF25‐1 from Pancreatic Cancer Cell Promotes Pancreatic Stellate Cell Uptake of Asparagine to Advance Chemoresistance

Advanced Science
Extensive fibrous stroma plays an important role in gemcitabine (GEM) resistance. However, the mechanism by which pancreatic cancer cells interact with pancreatic stellate cells (PSCs) to promote GEM resistance remains unclear.
Miao Yu, Mingxin Su, Zhenfeng Tian, Lele Pan, Zongmeng Li, Enlai Huang, Yinting Chen   +6 more
doaj   +1 more source

Sex-specific effects of exogenous asparagine on colorectal tumor growth, 17β-estradiol levels, and aromatase

Pharmacological Research
Sex-related differences in asparagine metabolism are associated with cancer prognosis. However, the effect of exogenous asparagine on colorectal cancer (CRC) growth in men and women remains unclear.
Oladimeji Aladelokun, Katherine Benitez, Yuying Wang, Abhishek Jain, Domenica Berardi, Georgio Maroun, Xinyi Shen, Jatin Roper, Joanna Gibson, Kaelyn Sumigray, Sajid A. Khan, Caroline H. Johnson   +11 more
doaj   +1 more source

A Mouse Amidase Specific for N-terminal Asparagine: the gene, the enzyme, and their function in the N-end rule pathway [PDF]

, 1996
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. In both fungi and mammals, the tertiary destabilizing N-terminal residues asparagine and glutamine function through their conversion, by enzymatic ...
Arfin, Stuart M., Bradshaw, Ralph A., Copeland, Neal G., Grigoryev, Sergei, Jenkins, Nancy A., Kwon, Yong Tae, Stewart, Albert E., Varshavsky, Alexander   +7 more
core  

Amino acids in the uterine luminal fluid reflects the temporal changes in transporter expression in the endometrium and conceptus during early pregnancy in cattle [PDF]

, 2014
In cattle, conceptus-maternal interactions are critical for the establishment and maintenance of pregnancy. A major component of this early interaction involves the transport of nutrients and secretion of key molecules by uterine epithelial cells to help
Bazer, Fuller W., Forde, Niamh, Kelly, Alan K., Lonergan, Pat, Mamo, Solomon, Simintiras, Constantine A., Spencer, Thomas E., Sturmey, Roger, Ye, Xiaoqin   +8 more
core   +5 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Asparagine Synthetase Gene OsASN2 Is Crucial for Rice Seed Development and Germination

Plants
Seed development plays a critical role in determining both crop yield and grain quality in rice. As a key nutrient storage organ, the rice endosperm development not only contributes to grain filling but also plays an essential role during the early ...
Rui Hu, Kaiming Liang, Xiangyu Hu, Meijuan Li, Qunhuan Ye, Yuanhong Yin, Cai Tang, Xinyu Wang, Youqiang Fu, Junfeng Pan, Mingyong Zhang, Xuhua Zhong   +11 more
doaj   +1 more source

Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancer [PDF]

, 2023
Lingeng Lu, Qian Zhang, Xinyi Shen, Pinyi Zhen, Audrey Marin, Rolando García-Milian, Jatin Roper, Sajid Khan, Caroline H. Johnson   +8 more
openalex   +1 more source