Results 71 to 80 of about 202,771 (390)

Competitive pathways for peptide deamidation [PDF]

, 2011
Asparagine (Asn) residues spontaneously – yet non-enzymatically – deamidate to form aspartate under physiological conditions, causing time-dependent changes in the conformation of proteins, limiting their lifetime [1]. The 'molecular clocks' hypothesis [
Bulo, RE, Catak, Saron, De Sterck, Bart, Van Speybroeck, Veronique, Waroquier, Michel   +4 more
core  

Predicting protein decomposition: the case of aspartic-acid racemization kinetics [PDF]

, 1999
The increase in proportion of the non-biological (D-) isomer of aspartic acid (Asp) relative to the L- isomer has been widely used in archaeology and geochemistry as a tool for dating. The method has proved controversial, particularly when used for bones.
A. C. T. van Duin, Bongers J., Brennan T. V., Brunauer L. S., Capasso S., Capasso S., Cleland J. L., D. E. G. Briggs, Dru¡el E. R. M., E. Hagelberg, E. R. Waite, Fujii N., Fujisawa R., G. Eglington, Geiger T., Goodfriend G. A., Julg A., M. J. Collins, M. K. Jones, Mu, Ohtani S., Patel K., Shimoyama A., Stevenson C. L., Tyler-Cross R.   +24 more
core   +3 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Acrylamide formation in potato products [PDF]

, 2006
End of Project ReportAcrylamide, a substance classified as a potential carcinogen, occurs in heated starchy foods at concentrations many times in excess of levels permitted in drinking water. Early surveys indicated that levels of acrylamide in potato
Brunton, Nigel, Butler, Francis, Cummins, Enda, Danaher, Martin, Gormley, Ronan T., O'Keeffe, Michael   +5 more
core  

High-pressure Raman study of L-alanine crystal

, 2000
Pressure-dependent Raman scattering studies in the range 0.0 -- 32 kbar were carried out in L-alanine in order to investigate its external mode phonon spectra in relation to the phase transitions in the crystal.
A.J.D. Moreno, A.M.R. Teixeira, A.P. Ayala, Adamowicz, F.E.A. Melo, Forss, J. Mendes Filho, J.M. Sasaki, Jackson, Jonsson, Kwok, Lemanov, Loh, Machida, Migliori, Moreno, P.T.C. Freire, Ramanadham, Shoemaker, Silva, Simpson, Wang   +21 more
core   +2 more sources

Seasonal Response of Workers of the Allegheny Mound Ant, \u3ci\u3eFormica Exsectoides\u3c/i\u3e (Hymenoptera: Formicidae) to Artificial Honeydews of Varying Nutritional Content [PDF]

, 2018
Field colonies of Allegheny mound ants, Formica exsectoides, were tested at monthly intervals throughout the summer to assess their preference for artificial honeydews containing varying compositions of sugars and amino acids.
Bristow, C. M, Yanity, E.
core   +2 more sources

Thermal decomposition of the amino acids glycine, cysteine, aspartic acid, asparagine, glutamic acid, glutamine, arginine and histidine

bioRxiv, 2017
BackgroundThe pathways of thermal instability of amino acids have been unknown. New mass spectrometric data allow unequivocal quantitative identification of the decomposition products.ResultsCalorimetry, thermogravimetry and mass spectrometry were used ...
I. Weiss, Christina Muth, R. Drumm, H. Kirchner   +3 more
semanticscholar   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

Asparagine synthetase: Function, structure, and role in disease

Journal of Biological Chemistry, 2017
Asparagine synthetase (ASNS) converts aspartate and glutamine to asparagine and glutamate in an ATP-dependent reaction. ASNS is present in most, if not all, mammalian organs, but varies widely in basal expression. Human ASNS activity is highly responsive
C. Lomelino, J. Andring, R. McKenna, M. Kilberg   +3 more
semanticscholar   +1 more source