Results 61 to 70 of about 149,328 (227)

Nicotiana benthamiana asparagine synthetase associates with IP‐L and confers resistance against tobacco mosaic virus via the asparagine‐induced salicylic acid signalling pathway

Molecular plant pathology, 2021
Asparagine synthetase is a key enzyme that catalyses the conversion of amide groups from glutamine or ammonium to aspartate, which leads to the generation of asparagine. However, the role of asparagine synthetase in plant immunity remains largely unknown.
Changyun Liu, Shaorui Tian, Xing Lv, Y. Pu, Hao-Ran Peng, Guang-Jin Fan, Xiaozhou Ma, Lisong Ma, Xianchao Sun   +8 more
semanticscholar   +1 more source

Asparagine metabolism in higher plants

, 1975
The factors causing the production of large amounts of asparagine in seedlings, excised leaves, and in the transport system of legumes and certain trees are discussed. An attempt has been made to correlate the radioactive precursor studies with the known
P.J. Lea, Lea, P. J., L. Fowden, Fowden, L.   +3 more
core   +1 more source

Targeting NAT10 inhibits osteosarcoma progression via ATF4/ASNS-mediated asparagine biosynthesis

Cell Reports Medicine
Summary: Despite advances in treatment, the prognosis of patients with osteosarcoma remains unsatisfactory, and searching for potential targets is imperative.
Yutong Zou, Siyao Guo, Lili Wen, Dongming Lv, Jian Tu, Yan Liao, Weidong Chen, Ziyun Chen, Hongbo Li, Junkai Chen, Jingnan Shen, Xianbiao Xie   +11 more
doaj   +1 more source

Asparagine: a key metabolic junction in targeted tumor therapy.

Pharmacological Research
Nutrient bioavailability in the tumor microenvironment plays a pivotal role in tumor proliferation and metastasis. Among these nutrients, glutamine is a key substance that promotes tumor growth and proliferation, and its downstream metabolite asparagine ...
Xuan Wang, Weijian Gong, X. Xiong, Xue-Mei Jia, Juan Xu   +4 more
semanticscholar   +1 more source

QUANTUM-CHEMICAL SIMULATION OF THE INTERACTION OF AMINO ACIDS WITH CALCIUM CARBONATE

Современная наука и инновации, 2023
This article presents the results of quantum chemical modeling of the interaction of the CO32-anion with a number of proteinogenic amino acids to identify the most energetically advantageous system and further compare with the results of a laboratory ...
D. M. Remizov, A. A. Blinova, M. A. Pirogov, D. G. Maglakelidze, P. S. Leontiev   +4 more
doaj   +1 more source

Asparagine Dependency is a Targetable Metabolic Vulnerability in TP53-Altered Castration-Resistant Prostate Cancer

Cancer Research
The TP53 tumor suppressor is frequently altered in lethal, castration-resistant prostate cancer (CRPC). However, to date there are no effective treatments that specifically target TP53 alterations. Using transcriptomic and metabolomic analyses, we showed
Young A. Yoo, Songhua Quan, William Yang, Qianyu Guo, Yara Rodríguez, Zachary R. Chalmers, Mary F Dufficy, Barbara Lackie, Vinay Sagar, K. Unno, M. Truica, N. Chandel, S. Abdulkadir   +12 more
semanticscholar   +1 more source

ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase

Cell Metabolism, 2020
Summary Activating transcription factor 4 (ATF4) is a master transcriptional regulator of the integrated stress response (ISR) that enables cell survival under nutrient stress.
Robert T. Williams, Rohiverth Guarecuco, Leah A. Gates, D. Barrows, Maria C. Passarelli, Bryce W. Carey, Lou Baudrier, Swarna Jeewajee, Konnor C. La, Benjamin Prizer, S. Malik, J. Garcia-Bermudez, Xiphias Ge Zhu, J. Cantor, H. Molina, Thomas S. Carroll, Robert G. Roeder, O. Abdel-Wahab, C. D. Allis, Kıvanç Birsoy   +19 more
semanticscholar   +1 more source

Thermodynamic study of asparagine and glycyl-asparagine using computational methods [PDF]

, 2015
This work aimed to develop an ab initio procedure for accurately calculating pKa values and applied it to study the acidity of asparagine and glycyl-asparagine.
Farhoush Kiani, Hannaneh Behzadi, Behzadi,Hannaneh, Fardad Koohyar, Kiani,Farhoush, Koohyar,Fardad   +5 more
core   +1 more source

Food safety: Structure and expression of the asparagine synthetase gene family of wheat [PDF]

, 2016
Asparagine is an important nitrogen storage and transport molecule, but its accumulation as a free amino acid in crops has implications for food safety because free asparagine is a precursor for acrylamide formation during cooking and processing ...
Gao, Runhong, Halford, Nigel G., Powers, S. J., Gao, R., Powers, Stephen J., Huang, Jianhua, Xu, H., Curtis, Tanya Y., Halford, N. G., Xu, Hongwei, Curtis, T. Y., Huang, J.   +11 more
core   +1 more source

Effects of Chickpea Protein on Carbohydrate Reactivity in Acrylamide Formation in Low Humidity Model Systems

Foods, 2020
Asparagine and reducing sugars are the principal precursors of acrylamide in foods. Their main sources in pastries are flour and hen egg yolks. One method of reducing acrylamide content in food may be to add a chickpea protein preparation. The aim of the
Karolina Miśkiewicz, Justyna Rosicka-Kaczmarek, Ewa Nebesny   +2 more
doaj   +1 more source