Knockdown of asparagine synthetase A renders Trypanosoma brucei auxotrophic to asparagine.
PLoS Neglected Tropical Diseases, 2013 Asparagine synthetase (AS) catalyzes the ATP-dependent conversion of aspartate into asparagine using ammonia or glutamine as nitrogen source. There are two distinct types of AS, asparagine synthetase A (AS-A), known as strictly ammonia-dependent, and ...
Inês Loureiro +8 more
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Asparagine synthetase deficiency: A novel case with an unusual molecular mechanism [PDF]
Molecular Genetics and Metabolism Reports, 2019 We report the case of a girl with Asparagine synthetase deficiency, an autosomal recessive metabolic disorder characterized by severe microcephaly and epileptic encephalopathy secondary to pathogenic variants in the ASNS gene.
Marie Faoucher +11 more
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Characterizing asparagine synthetase deficiency variants in lymphoblastoid cell lines [PDF]
JIMD Reports, 2023 Asparagine synthetase (ASNS) catalyzes the synthesis of asparagine (Asn) from aspartate and glutamine. Biallelic mutations in the ASNS gene result in ASNS Deficiency (ASNSD).
Stephen J. Staklinski +7 more
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Reduced free asparagine in wheat grain resulting from a natural deletion of TaASN-B2: investigating and exploiting diversity in the asparagine synthetase gene family to improve wheat quality [PDF]
BMC Plant Biology, 2021 Background Understanding the determinants of free asparagine concentration in wheat grain is necessary to reduce levels of the processing contaminant acrylamide in baked and toasted wheat products.
Joseph Oddy +11 more
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Asparagine Synthetase-Mediated l-Asparagine Metabolism Disorder Promotes the Perineural Invasion of Oral Squamous Cell Carcinoma [PDF]
Frontiers in Oncology, 2021 Dysregulated amino acids metabolism reciprocally interplays with evolutionary phenotypic characteristics of cancer cells to enhance metastasis. The high metastasis potential of oral squamous cell carcinoma (OSCC) can manifest with perineural invasion ...
Yong Fu +11 more
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Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK SignalingSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2020 Asparaginase (ASNase) causes pancreatitis in approximately 10% of leukemia patients, and the mechanisms underlying this painful complication are not known.
Amitava Mukherjee +9 more
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Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression [PDF]
EMBO Molecular MedicinePolycystic kidney disease (PKD) is a genetic disorder characterized by bilateral cyst formation. We showed that PKD cells and kidneys display metabolic alterations, including the Warburg effect and glutaminolysis, sustained in vitro by the enzyme ...
Sara Clerici +16 more
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Severe microcephaly and metabolic epilepsy due to asparagine synthetase deficiency [PDF]
Annals of Indian Academy of Neurology, 2023 Arushi G Saini +3 more
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Correction: Knockdown of Asparagine Synthetase A Renders Auxotrophic to Asparagine.
PLoS Neglected Tropical Diseases, 2013 Inês Loureiro +7 more
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Asparagine Synthetase Chemotherapy [PDF]
Annual Review of Biochemistry, 2006 Modern clinical treatments of childhood acute lymphoblastic leukemia (ALL) employ enzyme-based methods for depletion of blood asparagine in combination with standard chemotherapeutic agents. Significant side effects can arise in these protocols and, in many cases, patients develop drug-resistant forms of the disease that may be correlated with up ...
Nigel G J, Richards, Michael S, Kilberg
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