Cost-analysis of treatment of childhood acute lymphoblastic leukemia with asparaginase preparations: the impact of expensive chemotherapy [PDF]
Haematologica, 2013 Asparaginase is an expensive drug, but important in childhood acute lymphoblastic leukemia. In order to compare costs of PEGasparaginase, Erwinia asparaginase and native E.
Wing H. Tong +6 more
doaj +4 more sources
Marine-derived L-asparaginase: unlocking marine power in anti-tumor therapeutics [PDF]
Frontiers in ImmunologyL-asparaginase, a critical enzyme for cancer therapy, has been primarily produced by microbes. Researches are being conducted to identify better stabilizing, low immunogenicity and highly active alternative sources has focused on marine microorganisms ...
Ritika Gopalakrishnan +5 more
doaj +2 more sources
L‒asparaginase activity in some endophytic fungi: Glutaminase‒free and low urease co‒activities. [PDF]
PLoS ONEIn this study, L‒asparaginase production in several endophytic fungi was evaluated along with their L‒glutaminase and urease co-activities. The effect of L‒asparagine and different culture media on L-asparaginase production were also evaluated. Among the
Zahra Zaeimian +2 more
doaj +2 more sources
Isolation and screening of l-asparaginase free of glutaminase and urease from fungal sp. [PDF]
3 Biotech, 2016 l-Asparaginase is a chemotherapeutic drug used in the treatment of acute lymphoblastic leukaemia (ALL), a malignant disorder in children. l-Asparaginase helps in removing acrylamide found in fried and baked foods that is carcinogenic in nature.
Kruthi Doriya, Devarai Santhosh Kumar
exaly +3 more sources
Recombinant L-asparaginase from Stenotrophomonas maltophilia: a promising low-immunogenic anticancer agent [PDF]
Microbial Cell FactoriesL-asparaginase is a crucial enzyme used in chemotherapy regimens for the treatment of acute lymphoblastic leukemia (ALL), its incorporation in the pediatric treatment protocols helped in achieving a high cure rate.
Nada A. Abdelrazek +4 more
doaj +2 more sources
Haematologica, 2023 For several decades, asparaginase has been considered world-wide as an essential component of combination chemotherapy for the treatment of childhood acute lymphoblastic leukemia (ALL).
Wing H. Tong, Carmelo Rizzari
doaj +1 more source
Microorganisms, 2021 L-asparaginase (E.C.3.5.1.1) hydrolyzes L-asparagine to L-aspartic acid and ammonia, which has been widely applied in the pharmaceutical and food industries.
Ruiying Jia +5 more
doaj +1 more source
Erythrocytes as Carriers of Therapeutic Enzymes. [PDF]
, 2020 Therapeutic enzymes are administered for the treatment of a wide variety of diseases. They exert their effects through binding with a high affinity and specificity to disease-causing substrates to catalyze their conversion to a non-noxious product, to ...
Bax, BE
core +1 more source
Structural Characterization of the Loop at the Alpha-Subunit C-Terminus of the Mixed Lineage Leukemia Protein Activating Protease Taspase1. [PDF]
, 2016 Acknowledgments We acknowledge the Fonds of Chemical Industry for funding JvdB by their Chemiefonds grant and the DFG for funding PB and CB (CRC 1093). Additional gratitude goes to Shirley Knauer for providing Taspase1 expression clones.
Bayer, Peter +4 more
core +11 more sources
Protracted Administration of L-Asparaginase in Maintenance Phase Is the Risk Factor for Hyperglycemia in Older Patients with Pediatric Acute Lymphoblastic Leukemia. [PDF]
PLoS ONE, 2015 Although L-asparaginase related hyperglycemia is well known adverse event, it is not studied whether the profile of this adverse event is affected by intensification of L-asparaginase administration.
Hideki Yoshida +19 more
doaj +1 more source