Results 1 to 10 of about 15,191 (179)

Assessment of PEG-Asparaginase and Erwinia Asparaginase Activity Under Variable Storage Conditions [PDF]

Pharmaceutics
Background: PEG-Asparaginase and Erwinia asparaginase are enzyme-based anticancer therapies used in the treatment of acute lymphoblastic leukaemia (ALL) and lymphoblastic lymphoma (LBL), where adequate plasma enzyme activity is required for therapeutic ...
Søren Aleksander Friederici Dahl, Elke Hoffmann-Lücke, Birgitte Klug Albertsen, Eva Greibe   +3 more
doaj   +2 more sources

L‒asparaginase activity in some endophytic fungi: Glutaminase‒free and low urease co‒activities. [PDF]

PLoS ONE
In this study, L‒asparaginase production in several endophytic fungi was evaluated along with their L‒glutaminase and urease co-activities. The effect of L‒asparagine and different culture media on L-asparaginase production were also evaluated. Among the
Zahra Zaeimian, Khalil-Berdi Fotouhifar, Mohsen Farzaneh   +2 more
doaj   +2 more sources

Marine-derived L-asparaginase: unlocking marine power in anti-tumor therapeutics [PDF]

Frontiers in Immunology
L-asparaginase, a critical enzyme for cancer therapy, has been primarily produced by microbes. Researches are being conducted to identify better stabilizing, low immunogenicity and highly active alternative sources has focused on marine microorganisms ...
Ritika Gopalakrishnan, Kamala Kannan, Ragul Gunasekaran, Priya Ramachandran, Dhanraj Ganapathy, Pitchiah Sivaperumal   +5 more
doaj   +2 more sources

Recombinant L-asparaginase from Stenotrophomonas maltophilia: a promising low-immunogenic anticancer agent [PDF]

Microbial Cell Factories
L-asparaginase is a crucial enzyme used in chemotherapy regimens for the treatment of acute lymphoblastic leukemia (ALL), its incorporation in the pediatric treatment protocols helped in achieving a high cure rate.
Nada A. Abdelrazek, Sarra E. Saleh, Amal E. Ali, Mohammad M. Aboulwafa, Marwa M. Raafat   +4 more
doaj   +2 more sources

Microbial L-asparaginase for Application in Acrylamide Mitigation from Food: Current Research Status and Future Perspectives

Microorganisms, 2021
L-asparaginase (E.C.3.5.1.1) hydrolyzes L-asparagine to L-aspartic acid and ammonia, which has been widely applied in the pharmaceutical and food industries.
Ruiying Jia, Xiao Wan, Xu Geng, Deming Xue, Zhenxing Xie, Chaoran Chen   +5 more
doaj   +1 more source

Back to the future: the amazing journey of the therapeutic anti-leukemia enzyme asparaginase Erwinia chrysanthemi

Haematologica, 2023
For several decades, asparaginase has been considered world-wide as an essential component of combination chemotherapy for the treatment of childhood acute lymphoblastic leukemia (ALL).
Wing H. Tong, Carmelo Rizzari
doaj   +1 more source

Protracted Administration of L-Asparaginase in Maintenance Phase Is the Risk Factor for Hyperglycemia in Older Patients with Pediatric Acute Lymphoblastic Leukemia. [PDF]

PLoS ONE, 2015
Although L-asparaginase related hyperglycemia is well known adverse event, it is not studied whether the profile of this adverse event is affected by intensification of L-asparaginase administration.
Hideki Yoshida, Toshihiko Imamura, Akiko M Saito, Yoshihiro Takahashi, So-ichi Suenobu, Daiichiro Hasegawa, Takao Deguchi, Yoshiko Hashii, Hirohide Kawasaki, Mikiya Endo, Hiroki Hori, Nobuhiro Suzuki, Yoshiyuki Kosaka, Koji Kato, Keiko Yumura-Yagi, Junichi Hara, Megumi Oda, Atsushi Sato, Keizo Horibe, Japan Association of Childhood Leukemia Study   +19 more
doaj   +1 more source

Hypersensitivity reactions to asparaginase in mice are mediated by anti-asparaginase IgE and IgG and the immunoglobulin receptors FcεRI and FcγRIII

Haematologica, 2019
Asparaginase is an important drug for the treatment of leukemias. However, anti-asparaginase antibodies often develop, which can decrease asparaginase drug levels and increase the risk of relapse.
Sanjay Rathod, Manda Ramsey, Mary V. Relling, Fred D. Finkelman, Christian A. Fernandez   +4 more
doaj   +1 more source

Cost-analysis of treatment of childhood acute lymphoblastic leukemia with asparaginase preparations: the impact of expensive chemotherapy

Haematologica, 2013
Asparaginase is an expensive drug, but important in childhood acute lymphoblastic leukemia. In order to compare costs of PEGasparaginase, Erwinia asparaginase and native E.
Wing H. Tong, Inge M. van der Sluis, Cathelijne J.M. Alleman, Raphaële R.L. van Litsenburg, Gertjan J. L. Kaspers, Rob Pieters, Carin A. Uyl-de Groot   +6 more
doaj   +1 more source

Investigating the L-asparaginase Production in the Yeast Yarrowia ‎Lipolytica [PDF]

Biological Journal of Microorganism, 2018
Introduction: L-Asparaginase catalyzes the hydrolysis of L-asparagine to L-aspartic acid and ammonia. This enzyme is used for the treatment of patients with acute lymphoblastic leukemia, melanosarcoma and lymphosarcoma.
Farshad Darvishi, Fereshteh Shamsi
doaj   +1 more source