Results 21 to 30 of about 30,573 (214)

Oligodendroglioma cells lack glutamine synthetase and are auxotrophic for glutamine, but do not depend on glutamine anaplerosis for growth [PDF]

, 2018
In cells derived from several types of cancer, a transcriptional program drives high consumption of glutamine (Gln), which is used for anaplerosis, leading to a metabolic addiction for the amino acid. Low or absent expression of Glutamine Synthetase (GS),
Andreoli, Roberta, Bianchi, Massimiliano G., Bussolati, Ovidio, Chiu, Martina, Ciociola, Tecla, Lagrasta, Costanza A M, Ottaviani, Laura, Tardito, Saverio, Taurino, Giuseppe   +8 more
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Isolasi Enzim L-Asparaginase dari Rimpang Temulawak (Curcuma xanthorrhiza Roxb.) dan Uji Potensi terhadap Kultur Sel Leukemia Tipe K562

Jurnal Kimia Sains dan Aplikasi, 2010
Enzim L-Asparaginase merupakan enzim yang menghidrolisis L-asparagin menjadi asam L-aspartat dan amonia. L-Asparaginase dapat digunakan untuk mengobati penyakit kanker, yang bekerja dengan cara menghambat sintesis protein sel kanker tanpa merusak sel ...
Oktarina Puspitasari, Wuryanti Wuryanti
doaj   +1 more source

L-asparaginase: New about Well-Known Drug

Педиатрическая фармакология, 2021
The history of asparaginase clinical use is inextricably linked to the improvement of treatment programs for acute lymphoblastic leukaemia (ALL). Asparaginase, obtained from E.
Yuliya S. Korkina, Timur T. Valiev
doaj   +1 more source

Glutamine Phosphoribosylpyrophosphate Amidotransferase-independent Phosphoribosyl Amine Synthesis from Ribose 5-Phosphate and Glutamine or Asparagine [PDF]

, 2007
Phosphoribosylamine (PRA) is the first intermediate in the common pathway to purines and thiamine and is generated in bacteria by glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase (EC 2.4.2.14) from PRPP and glutamine.
Downs, Diana M., Koenigsknecht, Mark J., Ramos, Itzel   +2 more
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Asparaginase Therapy in Pediatric Acute Lymphoblastic Leukemia: A Focus on the Mode of Drug Resistance

Pediatrics and Neonatology, 2015
Asparaginase is one of the most important chemotherapeutic agents against pediatric acute lymphoblastic leukemia (ALL), the most common form of childhood cancer.
Shih-Hsiang Chen
doaj   +1 more source

Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target [PDF]

, 2018
Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed in the last years.
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Asparaginase-Induced Acute Necrotizing Pancreatitis Resulting in Chronic Pancreatitis and Pseudocyst in an Adult with Acute Lymphocytic Leukemia

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2023
L-Asparaginase is one of the main chemotherapy regiments for acute lymphocytic leukemia (ALL) management. Acute pancreatitis is one of the serious side effects of l-asparaginase administration and may lead to interruption of chemotherapy cycle. Long term
Randy Adiwinata, Bradley Jimmy Waleleng, Harlinda Haroen, Linda Rotty, Fandy Gosal, Luciana Rotty, Cecillia Hendratta, Pearla Lasut, Jeanne Winarta, Andrew Waleleng, Michael Tendean   +10 more
doaj   +1 more source

Solid state fermentation: An effective fermentation strategy for the production of L-asparaginase by Fusarium culmorum (ASP-87) [PDF]

, 2017
Production of L-asparaginase by Fusarium culmorum (ASP-87) isolated from tropical soil was investigated under solid state fermentation on a laboratory scale using sixty five (65) agro based materials.
Janakiraman, S., Meghavarnam, A.K.
core   +1 more source

Refolding and purification of recombinant L-asparaginase from inclusion bodies of E. coli in to active tetrameric protein

Frontiers in Microbiology, 2014
A tetrameric protein of therapeutic importance, Escherichia coli L-Asparaginase-II was expressed in Escherichia coli as inclusion bodies. Asparaginase inclusion bodies were solubilized using low concentration of urea and refolded into active tetrameric ...
Arun K Upadhyay, Anupam eSingh, K J Mukherjee, Amulya Kumar Panda   +3 more
doaj   +1 more source

Cloning and Gene Expression of AnsZ Encoding L-Asparaginase Enzyme from Local Bacillus sp.

Microbiology Indonesia, 2014
L-asparaginase is an enzyme that catalyzes the hydrolysis of L-asparagine into L-aspartic acid and ammonia. In medical aspect, L-asparaginase especially those came from E.
RIMA AZARA, IS HELIANTI, JONI KUSNADI, YUNIANTA YUNIANTA   +3 more
doaj   +1 more source