Safety of mRNA-based COVID-19 vaccination in paediatric patients with a PEG-asparaginase allergy [PDF]
EJC Paediatric Oncology, 2023 Background: Children treated for a malignancy are at risk to develop serious illness from a COVID-19 infection. Pegylated E. coli asparaginase (PEG-asparaginase) is used in the treatment of acute lymphoblastic leukemia. Allergy to this drug is common and
Wim J E Tissing +2 more
exaly +9 more sources
Safety of re‐challenging adults with acute lymphoblastic leukemia with PEG‐asparaginase‐induced severe hypertriglyceridemia when treated with a pediatric‐inspired regimen [PDF]
EJHaem, 2023 PEG‐asparaginase is used as a treatment for Philadelphia‐negative acute lymphoblastic leukemia. In pediatric studies, triglycerides (TGs) were affected more by PEG‐asparaginase than by native L‐asparaginase (10.0% vs. 5.5%).
Hassan Sibai, Vikas Gupta, Dawn Maze
exaly +5 more sources
Diabetic ketoacidosis following PEG-asparaginase therapy [PDF]
Endocrinology, Diabetes & Metabolism Case Reports, 2018 We report a case of a 21-year-old African American female with history of pre-diabetes, and a diagnosis of a rare leukemia, blastic-plasmacytoid dendritic neoplasm (BPDCN), who developed diabetic ketoacidosis (DKA) after the third dose of PEG ...
Miriam Hinaa Ahmad, Ismat Shafiq
doaj +7 more sources
Case report: Hyperosmolar hyperglycemic syndrome secondary to PEG-asparaginase-induced hypertriglyceridemia and pancreatitis [PDF]
Frontiers in Oncology, 2023 Pegylated (PEG)-asparaginase is an established treatment for acute lymphoblastic leukemias that exhibits an antitumor effect by depleting asparagine, an amino acid essential for leukemia cell protein synthesis. Pancreatitis with hypertriglyceridemia is a
Todd William Mudd +3 more
exaly +6 more sources
PEG-asparaginase induced severe hypertriglyceridemia [PDF]
Archives of Endocrinology and Metabolism, 2015 Asparaginase (ASP) is an effective chemotherapy agent extensively used in children with acute lymphocytic leukemia (ALL). There has been a recent interest in using ASP in adults with ALL, particularly the less toxic pegylated (PEG) formulation ...
Rodolfo J. Galindo +3 more
doaj +7 more sources
Increase in peg-asparaginase clearance as a predictor for inactivation in patients with acute lymphoblastic leukemia. [PDF]
Leukemia, 2023 Abstract Asparaginase is an essential component of acute lymphoblastic leukemia (ALL) therapy, yet its associated toxicities often lead to treatment discontinuation, increasing the risk of relapse. Hypersensitivity reactions include clinical allergies, silent inactivation, or allergy-like responses.
Dam M +17 more
europepmc +9 more sources
PEG-asparaginase and native Escherichia coli L-asparaginase in acute lymphoblastic leukemia in children and adolescents: a systematic review [PDF]
Hematology, Transfusion and Cell Therapy, 2020 Introduction: Acute lymphoblastic leukemia (ALL) is the cancer with the highest incidence in childhood and adolescence, and pharmacotherapy is the primary form of treatment.
Gabriela Mosegui +2 more
exaly +4 more sources
Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice [PDF]
Acta Pharmaceutica Sinica B, 2021 PEGylated-l-asparaginase (PEG-ASNase) is a chemotherapeutic agent used to treat pediatric acute lymphoblastic leukemia (ALL). Its use is avoided in adults due to its high risk of liver injury including hepatic steatosis, with obesity and older age ...
Gundala Venkata Naveen Kumar +7 more
doaj +4 more sources
Assessment of PEG-Asparaginase and Erwinia Asparaginase Activity Under Variable Storage Conditions [PDF]
PharmaceuticsBackground: PEG-Asparaginase and Erwinia asparaginase are enzyme-based anticancer therapies used in the treatment of acute lymphoblastic leukaemia (ALL) and lymphoblastic lymphoma (LBL), where adequate plasma enzyme activity is required for therapeutic ...
Søren Aleksander Friederici Dahl +3 more
doaj +4 more sources
Case Report: Genetic Analysis of PEG-Asparaginase Induced Severe Hypertriglyceridemia in an Adult With Acute Lymphoblastic Leukaemia [PDF]
Frontiers in Genetics, 2022 PEG-Asparaginase (also known as Pegaspargase), along with glucocorticoids (predominantly prednisolone or dexamethasone) and other chemotherapeutic agents (such as cyclophosphamide, idarubicin, vincristine, cytarabine, methotrexate and 6-mercaptopurine ...
Arcangelo Iannuzzi +7 more
doaj +2 more sources