TOWARD OPTIMIZED TREATMENT: INCIDENCE OF HYPERSENSITIVITY REACTIONS AND INACTIVATIONS IN BRAZILIAN CHILDREN RECEIVING PEG-ASPARAGINASE FOR ACUTE LYMPHOBLASTIC LEUKEMIA [PDF]
Hematology, Transfusion and Cell TherapyIntroduction: PEG asparaginase (PEG-ASNase) is an essential drug in the treatment of acute lymphoblastic leukemia (ALL). However, asparaginase-related hypersensitivity and silent inactivation continue to represent clinical challenges. Objective: Describe
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Peg-asparaginase associated toxicities in children with acute lymphoblastic leukemia: A single-center cross-sectional study [PDF]
Pediatric Hematology Oncology JournalBackground: Leukemia is the most prevalent type of cancer affecting children, representing approximately 35% of cancer diagnoses in Saudi Arabia.
Sameh Awwad +6 more
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Incidence of venous thrombosis after peg-asparaginase in adolescent and young adults with acute lymphoblastic leukemia. [PDF]
Int J Hematol Oncol, 2020 There are limited data describing incidence of symptomatic venous thromboembolism (VTE) in adolescent and young adult (AYA) acute lymphoblastic leukemia (ALL) patients receiving peg-asparaginase.Single-institution retrospective analysis of 44 AYA ALL patients treated with peg-asparaginase.
Underwood B +16 more
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Asparaginase Hypersensitivity Reactions in NK/T-Cell Lymphomas [PDF]
Clinics and PracticeBackground/Objectives: Asparaginase (ASP)-based chemotherapy has substantially improved clinical outcomes in Epstein–Barr virus (EBV)-positive NK/T-cell lymphomas (NKTCL).
Javier Varela Gonzalez-Aller +8 more
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Intensified pegylated-asparaginase in consolidation therapy improved outcome of allogeneic hematopoietic stem cell transplantation for adult T-cell acute lymphoblastic leukemia [PDF]
Annals of HematologyResearch on the optimal consolidation therapy for adult T-cell acute lymphoblastic leukemia (T-ALL) remains limited, and how to integrate pediatric-inspired chemotherapy with allogeneic hematopoietic stem cell transplantation (SCT) is less addressed ...
Junjie Chen +13 more
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Early prediction of subsequent peg-asparaginase inactivation in acute lymphoblastic leukaemia patients-A NOPHO ALL2008 study. [PDF]
Br J HaematolPolyethylene glycol (peg)-asparaginase plays a crucial role in acute lymphoblastic leukaemia (ALL) treatment, yet its associated toxicity often leads to treatment discontinuation, elevating relapse risk. Hypersensitivity with inactivation of asparaginase
Dam M +18 more
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Activity of Erwinia-asparaginase after anaphylactic reaction to Peg-asparaginase
Anales de Pediatría (English Edition), 2019 Maria Micaela Viña Romero +4 more
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Clinical Characteristics of Intravenous PEG-Asparaginase Hypersensitivity Reactions in Patients Undergoing Treatment for Acute Lymphoblastic Leukemia [Formula: see text]. [PDF]
J Pediatr Oncol Nurs, 2018 Background: Asparaginase poses a substantial risk for hypersensitivity reactions during and after administration; however, these reactions vary by asparaginase formulation and administration route.
Browne EK +5 more
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L-asparaginase: New about Well-Known Drug
Педиатрическая фармакология, 2021 The history of asparaginase clinical use is inextricably linked to the improvement of treatment programs for acute lymphoblastic leukaemia (ALL). Asparaginase, obtained from E.
Yuliya S. Korkina, Timur T. Valiev
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PEG-Asparaginase Single-Agent Rescue in an Advanced Case of Monomorphic Epitheliotropic Intestinal T Cell Lymphoma [PDF]
, 2023 Purpose: MEITL is a very rare and highly aggressive peripheral T cell lymphoma with poor prognosis and for which there is no standard treatment. Treatment options for patients patients with relapsed/refractory disease are scarce and the choice of an
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