Results 31 to 40 of about 30,573 (214)

Safety of mRNA-based COVID-19 vaccination in paediatric patients with a PEG-asparaginase allergy

EJC Paediatric Oncology, 2023
Background: Children treated for a malignancy are at risk to develop serious illness from a COVID-19 infection. Pegylated E. coli asparaginase (PEG-asparaginase) is used in the treatment of acute lymphoblastic leukemia. Allergy to this drug is common and
Nancy Broos, Leiah J. Brigitha, Annemieke Schuurhof, Heike Röckmann-Helmbach, Wim J.E. Tissing, Rob Pieters, Inge M. van der Sluis, Marike B. Stadermann   +7 more
doaj   +1 more source

Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice [PDF]

, 2017
Obesity increases risk for liver toxicity by the anti-leukemic agent asparaginase, but the mechanism is unknown. Asparaginase activates the integrated stress response (ISR) via sensing amino acid depletion by the eukaryotic initiation factor 2 (eIF2 ...
Adams, Christopher M., Al-Baghdadi, Rana J. T., Anthony, Tracy G., Dixon, Joseph L., Goudie, Michael P., Hine, Christopher, Mirek, Emily T., Mitchell, James R., Nikonorova, Inna A., Wang, Yongping, Wek, Ronald C., Wetstein, Berish B.   +11 more
core   +1 more source

Albumin/asparaginase capsules prepared by ultrasound to retain ammonia [PDF]

, 2016
"Published online: 17 June 2016"Asparaginase reduces the levels of asparagine in blood, which is an essential amino acid for the proliferation of lymphoblastic malign cells. Asparaginase converts asparagine into aspartic acid and ammonia.
A Loureiro, A Loureiro, A Loureiro, A Ribeiro, AL Stecher, Ana Tinoco, Andreia Gomes, AO Elzoghby, AO Elzoghby, Artur Cavaco-Paulo, Artur Ribeiro, C Rizzari, CH Fu, César Oliveira, D Cappelletti, DS Kumar, E Bahreini, E Teodor, ET Baran, F Suzuki, GL Peterson, H Sah, HJ Muller, I Vina, IM Appel, J Jean-François, K Heitink-Pollé, L Nott, M Ehrman, M Nasseau, M Paulides, M Wetzler, NE El-Naggar, Pier Parpot, R Silva, R Wang, S Ghosh, SE Lyles, WH Tong, Y-Q Zhang, YQ Zhang   +40 more
core   +1 more source

Skrining Bakteri Termohalofilik Penghasil L-asparaginase dari Sumber Air Panas Wawolesea Sulawesi Tenggara dan Uji Aktivitas Enzimnya

Alchemy
L-asparaginase merupakan enzim yang mengubah L-asparagin menjadi L-aspartat. L-asparagin dapat dimanfaatkan oleh sel kanker leukemia sebagai salah satu sumber nutrisinya. Penambahan L-asparaginase dapat menghambat pertumbuhan sel kanker.
Muzuni Muzuni, Jamaluddin Jamaluddin, Suriana Suriana, Ardiansyah Ardiansyah, Nur Arfa Yanti   +4 more
doaj   +1 more source

Filamentous Fungi Producing l-Asparaginase with Low Glutaminase Activity Isolated from Brazilian Savanna Soil

Pharmaceutics, 2021
l-asparaginase is an enzyme used as treatment for acute lymphoblastic leukemia (ALL) due to its ability to hydrolyze l-asparagine, an essential amino acid synthesized by normal cells unlike neoplastic cells.
Marcela Freitas, Paula Souza, Samuel Cardoso, Kellen Cruvinel, Letícia Santos Abrunhosa, Edivaldo X. Ferreira Filho, João Inácio, Danilo Batista Pinho, Adalberto Pessoa, Pérola O. Magalhães   +9 more
doaj   +1 more source

The nutritional and cultural conditions in shake flask culture for improved production of L-Asparaginase from endophytic fungus Fusarium sp. LCJ324: A sequential statistical method

Italian Journal of Mycology, 2023
L-Asparaginase has a greater demand due to its potential application in the food industry as well as in the pharmaceutical industry. To meet this demand, optimization of nutritional as well as physical conditions is critical for scaling up the production
Elangovan Udayan, Anbarasu Kathiravan, John Joel Gnanadoss   +2 more
doaj   +1 more source

Allergic-like reactions to asparaginase: Atypical allergies without asparaginase inactivation [PDF]

, 2016
Background: Asparaginase is an important component of pediatric acute lymphoblastic leukemia (ALL) therapy. Unfortunately, this treatment is hampered by hypersensitivity reactions.
Escherich, G. (Gabriele), Kloos, R.Q.H. (Robin), Pieters, R. (Rob), Sluis, I.M. (Inge) van der   +3 more
core   +2 more sources

Asparaginase combined with discontinuous dexamethasone improves antileukemic efficacy without increasing osteonecrosis in preclinical models.

PLoS ONE, 2019
IntroductionCombination therapy for acute lymphoblastic leukemia (ALL) is highly effective but results in significant toxicity including osteonecrosis.
Seth E Karol, Laura J Janke, John C Panetta, Laura B Ramsey, Xiangjun Cai, Monique A Payton, David A Jenkins, William E Evans, Mary V Relling   +8 more
doaj   +1 more source

E. coli-Derived L-Asparaginase Retains Enzymatic and Cytotoxic Activity In Vitro for Canine and Feline Lymphoma after Cold Storage

Veterinary Medicine International, 2013
Background. L-asparaginase is effective in treating canine and feline lymphoma, however chemotherapy poses a significant financial cost to veterinary clients, limiting therapy for many pets.
Jackie M. Wypij, Holly C. Pondenis
doaj   +1 more source

Multiplex Modular Nanorobotic Systems with Catalytic Activity under Magnetic Navigation

Advanced Functional Materials, EarlyView.
We present modular nanorobots composed of a magnetic propulsion module and different extension modules carrying functional activities, assembled via DNA base pairing. The system integrates propulsion, optical tracking, enzymatic catalysis, and cell docking in a programmable manner.
Voichita Mihali, Xinan Huang, Lucie Motyckova, Nicolas Moreno Gomez, Michal Skowicki, Cora‐Ann Schoenenberger, Peer Fischer, Cornelia G. Palivan   +7 more
wiley   +1 more source