Results 51 to 60 of about 15,191 (179)

Shear‐Responsive Red Blood Cell Carriers for Targeted Drug Delivery to Constricted Arteries

Small, EarlyView.
Red blood cells are harnessed as mechanoresponsive carriers that exploit the elevated shear stress of stenotic arteries to transiently open membrane pores and release encapsulated therapeutics selectively at sites of arterial narrowing. By coupling vascular hemodynamics with RBC membrane mechanics, a hemodynamically activated platform for localized ...
Danielle Nemcovsky Amar, Rukiye Tuna, Tirosh Mekler, Merav Belenkovich, Dmitry Korneyev, Yevgeniy Kreinin, Anat Glozman, Josué Sznitman, Donald E. Ingber, Zixiang Leonardo Liu, Netanel Korin   +10 more
wiley   +1 more source

Nanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments

VIEW, EarlyView.
Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf, Yara Mashal, Afeefa Rao, Nasar Ata, Arun K. Iyer, Farhan Shah   +5 more
wiley   +1 more source

Effect of dose and schedule of L-asparaginase administration on early minimal residual disease in acute lymphoblastic leukemia

Indian Journal of Medical and Paediatric Oncology, 2019
Background and Objectives: L-asparaginase has become the backbone of acute lymphoblastic leukemia induction. In Berlin–Frankfurt–Munster (BFM) 95/2000 protocols, L-asparaginase was given twice weekly for initial 4 weeks.
Satyanker Gupta, Amit Sehrawat, Ketan Dang, Lalit Sharma, Sarita R. Jaiswal, Suparno Chakarbarti   +5 more
doaj   +1 more source

Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes, Rishi S. Kotecha, Derek J. Roebuck   +2 more
wiley   +1 more source

Role of L-asparaginase in acute lymphoblastic leukemia: focus on adult patients

Blood and Lymphatic Cancer: Targets and Therapy, 2012
Michael E RyttingDepartment of Pediatrics and Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USAAbstract: Asparaginase preparations deplete asparagine in acute lymphoblastic leukemia (ALL) blasts.
Rytting ME
doaj  

L-asparaginase is a PAR2 N-terminal protease that unmasks the PAR2 tethered ligand

Cell Death Discovery
L-asparaginase is an indispensable chemotherapeutic drug for patients with acute lymphoblastic leukemia (aLL), a life-threatening lymphoid neoplasm and the prime cause of cancer death among children.
Jung Kwon Lee, Karl Riabowol, Xidi Wang, Ki-Young Lee   +3 more
doaj   +1 more source

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source

Isolation and Purification of L-Asparaginase from Persian Gulf Streptomyces Isolates and Evaluation of It’s Cloned Gene Expression in Escherichia Coli by Real-Time and SDS-PAGE [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objective: Asparaginase enzymes are effective in treating lymphoblastic leukemia cancer. This enzyme is isolated from bacterial sources and commercially available as an anticancer drug.
Hadiseh Soofer, Kumarss Amini, Seyed Mohammad Masoud Shushtarian   +2 more
doaj  

Venous Thromboembolism in Hematologic Malignancies: Incidence, Risk Factors, and the Role of Direct Oral Anticoagulants

European Journal of Haematology, EarlyView.
ABSTRACT Thrombotic events, particularly venous thromboembolism (VTE), are a significant source of morbidity and mortality among patients with hematologic malignancies. These patients face unique challenges due to treatment‐related complications such as thrombocytopenia, coagulopathy, and heightened bleeding risk.
Mario Biglietto, Silvia Sorella, Erminia Baldacci, Massimo Breccia, Sabina Chiaretti, Marcello Capriata, Livia Donzelli, Gianna Maria D'Elia, Salvatore Giacomo Morano, Ilaria Del Giudice, Maurizio Martelli, Cristina Santoro, Antonio Chistolini   +12 more
wiley   +1 more source

Asparaginase Potentiates Glucocorticoid-Induced Osteonecrosis in a Mouse Model.

PLoS ONE, 2016
Osteonecrosis is a common dose-limiting toxicity of glucocorticoids. Data from clinical trials suggest that other medications can increase the risk of glucocorticoid-induced osteonecrosis.
Chengcheng Liu, Laura J Janke, Jitesh D Kawedia, Laura B Ramsey, Xiangjun Cai, Leonard A Mattano, Kelli L Boyd, Amy J Funk, Mary V Relling   +8 more
doaj   +1 more source