Results 71 to 80 of about 30,573 (214)

Effect of dose and schedule of L-asparaginase administration on early minimal residual disease in acute lymphoblastic leukemia

Indian Journal of Medical and Paediatric Oncology, 2019
Background and Objectives: L-asparaginase has become the backbone of acute lymphoblastic leukemia induction. In Berlin–Frankfurt–Munster (BFM) 95/2000 protocols, L-asparaginase was given twice weekly for initial 4 weeks.
Satyanker Gupta, Amit Sehrawat, Ketan Dang, Lalit Sharma, Sarita R. Jaiswal, Suparno Chakarbarti   +5 more
doaj   +1 more source

Metabolic Enzyme MeHNL11 Regulates MeCAS1b Transcription for Cyanide Reutilization in Response to Nitrate Deficiency in Cassava

Plant Biotechnology Journal, EarlyView.
ABSTRACT Cassava (Manihot esculenta Crantz) exhibits exceptional tolerance to infertile soils and contains abundant cyanogenic glucosides (CGs). Previous research has indicated that CGs can serve as a significant reservoir of organic nitrogen in plants.
Weitao Mai, Ruxue Bao, Xiaocheng Liu, Mengtao Li, Jinling Zhao, Huaifang Zhang, Yuan Yao, Haiyan Wang, Wenquan Wang, Changying Zeng, Xin Chen   +10 more
wiley   +1 more source

Anticancer L-Asparaginase and Phytoactive Compounds From Plant Against MDR (Methicillindrug resistant) and Fungal Isolates

Dose-Response, 2022
L-asparaginase is used in chemotherapy for acute lymphoblastic leukemia and other cancers. L-asparaginase derived from bacterial source triggers immune responses.
Ambreen Aisha, Saba Zahra, Imtiaz M. Tahir, Asim Hussain, Naheed Bano, Alishbah Roobi, Nadia Afsheen, Yasir Saleem   +7 more
doaj   +1 more source

Evaluation of the Utility of Baseline Echocardiogram in Patients With Standard Risk Precursor B‐Lymphoblastic Leukemia

Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.
ABSTRACT Background A routine baseline echocardiogram is often obtained prior to anthracycline administration in children with cancer. The utility of baseline echocardiogram is unclear in patients with standard risk B‐cell acute lymphoblastic leukemia (SR B‐ALL) as their anthracycline cumulative dose is low.
Ziyad Alrajhi, Alice Pozza, Luc Mertens, Adam Paul Yan, Sarah Alexander   +4 more
wiley   +1 more source

Isolation and Purification of L-Asparaginase from Persian Gulf Streptomyces Isolates and Evaluation of It’s Cloned Gene Expression in Escherichia Coli by Real-Time and SDS-PAGE [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objective: Asparaginase enzymes are effective in treating lymphoblastic leukemia cancer. This enzyme is isolated from bacterial sources and commercially available as an anticancer drug.
Hadiseh Soofer, Kumarss Amini, Seyed Mohammad Masoud Shushtarian   +2 more
doaj  

Managing toxicities with asparaginase-based therapies in adult ALL: summary of an ESMO Open–Cancer Horizons roundtable discussion

ESMO Open, 2020
With recent prospective clinical trials that used paediatric regimens with multiple doses of pegylated form of asparaginase (PEG asparaginase) in adults reporting significantly improved survival compared with historical data with regimens that used less ...
Kjeld Schmiegelow, Patrick W Burke, Dieter Hoelzer, Jae H Park, Dan Douer   +4 more
doaj   +1 more source

Conformity and controversies in the diagnosis, staging and follow-up evaluation of canine nodal lymphoma: a systematic review of the last 15 years of published literature [PDF]

, 2016
Diagnostic methods used in the initial and post-treatment evaluation of canine lymphoma are heterogeneous and can vary within countries and institutions. Accurate reporting of clinical stage and response assessment is crucial in determining the treatment
D. Stefanello, E. Morello, G. A. Polton, G. Lubas, I. Grant, J. Henriques, L. Marconato, M. Dacasto, null null, O. A. Garden, S. Comazzi, S. Sabattini, T. Hendrickx   +12 more
core   +1 more source

Incidence and Risk Factors of Serious Osteonecrosis in Pediatric Acute Lymphoblastic Leukemia: A CYP‐C Population‐Based Study

Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.
ABSTRACT Background Osteonecrosis (ON) is a debilitating complication of acute lymphoblastic leukemia (ALL) therapy. While numerous studies have explored its incidence and associated risk factors, investigations using large‐scale cohorts remain important to characterize ON across heterogeneous populations.
Noémie de Villiers, Chantal Éthier, Caroline Laverdière, Nathalie Alos, Thai Hoa Tran, Marie‐Claude Pelland‐Marcotte   +5 more
wiley   +1 more source

L-asparaginase is a PAR2 N-terminal protease that unmasks the PAR2 tethered ligand

Cell Death Discovery
L-asparaginase is an indispensable chemotherapeutic drug for patients with acute lymphoblastic leukemia (aLL), a life-threatening lymphoid neoplasm and the prime cause of cancer death among children.
Jung Kwon Lee, Karl Riabowol, Xidi Wang, Ki-Young Lee   +3 more
doaj   +1 more source

Optimization of physiological conditions for L-asparaginase production by endophytic fungi (Fusarium solani) isolated from Tinospora cordifolia (Willd.) Hook. F & Thomson [PDF]

, 2016
Asparaginase converts L-asparagine to L-aspartic acid and has received considerable attention in the recent years for its anti-carcinogenic potential. In the present investigation, the endophytic fungi isolated from T.
Fazilath Uzma, ., Narasimha Murthy, K., Srinivas, C.   +2 more
core