Results 91 to 100 of about 30,573 (214)

Optimization of Physiological Growth Conditions for Maximal Production of L-Asparaginase by Fusarium Species [PDF]

, 2015
L-asparaginase is an enzyme which catalyzes the hydrolysis of amino acid L-asparagine to L-aspartic acid and ammonia. Due to its utility in pharmaceutical as well as food industries, there has been a paramount interest on the production of this enzyme ...
Anil kumar Meghavarnam, ., Savitha Janakiraman, .   +1 more
core  

Biomimetic soft matter [PDF]

, 2011
Biomaterials are often soft materials. There is now growing interest in designing, synthesizing and characterising soft materials that mimic the properties of biological materials such as tissue, proteins, DNA or cells. Research on biomimetic soft matter
Hamley, Ian
core   +1 more source

Mediastinal Lymphoma in 70 Dogs Treated With Lomustine or Anthracycline‐Based Multi‐Agent Chemotherapy

Veterinary and Comparative Oncology, Volume 24, Issue 2, Page 382-392, June 2026.
ABSTRACT Primary mediastinal lymphoma is rare in dogs and literature exploring this disease is limited. Therefore, the aim of this study was to describe presentation, treatment and outcome in a large cohort of dogs with mediastinal lymphoma and explore prognostic factors including chemotherapy protocol. This retrospective multi‐institute study included
Diogo Machado, Jose Alvarez Picornell, Isabel Amores‐Fuster, Sarah Benjamin, Thomas Kearns, Alenka Lavra Zajc, Yike Bing, Katie A. McNaught, Maria Sava, Charlotte Johnston, Beth Rolf, Andrew D. Yale   +11 more
wiley   +1 more source

Systematic site-directed mutagenesis to characterize subunit interactions in E. coli asparaginase II, an enzyme [PDF]

, 2005
L-asparaginases (EC 3.5.1.1) catalyze the hydrolysis of L-asparagine to aspartic acid and ammonia. Asparaginases of bacterial origin have been used for over 40 years in the treatment of acute lymphatic leukemia (ALL).
Röhm, Klaus-Heinrich (Prof.), Verma, Shikha   +1 more
core   +1 more source

ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ETV4 coordinates a dual transcriptional program by upregulating MET and asparagine synthetase (ASNS). The resulting asparagine (Asn) secretion acts as a metabolic signal, reprogramming hepatic stellate cells (HSCs) and primary cancer‐associated fibroblasts (CAFs) toward an inflammatory phenotype. These activated stromal cells release HGF to sustain the
Dujiang Fu, Meijia Zhang, Maoping Cai, Miao Wang, Ziao Huang, Zesheng Lin, Yixin Liu, Wang Qian, Guopeng Chen, Yuxing Liang, Dongyi Wei, Jing xie, Picheng Yan, Yuanyuan Qu, Yongchang Wei   +14 more
wiley   +1 more source

Purification, characterization and antiproliferative activity of l-asparaginase from Aspergillus oryzae CCT 3940 with no glutaminase activity

Asian Pacific Journal of Tropical Biomedicine, 2016
Objective: To explore the anti-proliferative activity of purified l-asparaginase from Aspergillus oryzae CCT 3940 (A. oryzae). Methods: l-asparaginase was produced by submerged fermentation and purified to electrophoresis homogeneity by ionic exchanged ...
Fernanda Furlan Gonçalves Dias, Ana Lúcia Tasca Gois Ruiz, Adriana Della Torre, Helia Harumi Sato   +3 more
doaj   +1 more source

Phagocytic Mesothelial Cells in Pericardial Effusion Following Allogeneic Peripheral Blood Stem Cell Transplantation for Chronic Active Epstein–Barr Virus Infection: A Distinctive Cytomorphological and Immunocytochemical Case Study

Diagnostic Cytopathology, Volume 54, Issue 5, Page E136-E139, May 2026.
ABSTRACT Phagocytic activity of mesothelial cells is a rare phenomenon requiring careful differentiation from histiocytic hemophagocytosis to ensure appropriate patient management, as these phenomena could exhibit distinct clinical implications. In this study, we report a case of phagocytic mesothelial cells found in pericardial effusion that developed
Hidetoshi Satomi, Ayumi Ryu, Sei Murayama, Hiroya Kojima, Satoshi Tanada, Keiichiro Honma   +5 more
wiley   +1 more source

Uji Antikanker Isolat Bioaktif L-Asparaginase dari Kunyit Putih (Curcuma mangga Val.) terhadap Sel Kanker Serviks

Jurnal Kimia Sains dan Aplikasi, 2011
Kunyit putih (Curcuma mangga Val.) merupakan salah satu sumber L-asparaginase yang berpotensi sebagai bioaktif antikanker. Tujuan penelitian ini adalah untuk menentukan nilai LC50 dan potensi antikanker enzim L-asparaginase dari kunyit putih pada kultur ...
Citrawati Octavia Suprobo, Suprihati Suprihati, Wuryanti Wuryanti   +2 more
doaj   +1 more source

Impaired dexamethasone-related increase of anticoagulants is associated with the development of osteonecrosis in childhood acute lymphoblastic leukemia [PDF]

, 2008
Coagulation alterations may be involved in osteonecrosis in childhood acute lymphoblastic leukemia. Retrospectively, we evaluated the available coagulation parameters at diagnosis and during induction treatment of 161 acute lymphoblastic leukemia ...
Appel, I.M. (Inge), Heuvel-Eibrink, M.M. (Marry) van den, Pieters, R. (Rob), Winkel, M.L. (Mariël Lizet) te   +3 more
core   +3 more sources

From Power‐Law to Correlation‐Time Distributions: A Unified Framework for the Analysis of Nuclear Magnetic Relaxation Dispersion (NMRD) Profiles of Complex Biological Systems

Magnetic Resonance in Chemistry, Volume 64, Issue 5, Page 494-505, May 2026.
1H NMRD profiles of biological systems often follow a power‐law dependence rather than a Lorentzian dispersion. This behavior can arise from a broad distribution of correlation times, weighted by 1/τ 1−α. Validated across diverse systems such as sedimented proteins and biological tissues, this framework provides a physical interpretation of power‐law ...
Giacomo Parigi, Adam Kubrak
wiley   +1 more source