Results 101 to 110 of about 30,573 (214)

Production of L-asparaginase by filamentous fungi

Memorias do Instituto Oswaldo Cruz, 2004
L-asparaginase production was investigated in the filamentous fungi Aspergillus tamarii and Aspergillus terreus. The fungi were cultivated in medium containing different nitrogen sources. A. terreus showed the highest L-asparaginase (activity) production
Maria Inez de Moura Sarquis, Edna Maria Morais Oliveira, Alberdan Silva Santos, Gisela Lara da Costa   +3 more
doaj   +1 more source

The Contribution to the Assignment of Defined Daily Dose (DDD) to Antineoplastic Drugs of the Italian Working Group on DDD

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 5, May 2026.
ABSTRACT Purpose To report the experience of the Italian Working Group on DDD (Ita‐DDD‐wg) in assigning DDDs to a list of antineoplastic agents. Methods Active substances from the ATC L01 group with no assigned DDD and reimbursed at least once during 2021 by the Italian Healthcare Service were identified.
Angela Boccia, Giulia Hyeraci, Anna Girardi, Rosa Gini, Gianluca Trifirò, Ylenia Ingrasciotta, Andrea Spini, Valentina Ientile, Elisabetta Poluzzi, Giampiero Mazzaglia, Ippazio Cosimo Antonazzo, Casula Manuela, Elena Tragni, Olivia Leoni, Arianna Mazzone, Michele Ercolanoni, Martina Zanforlini, Ursula Kirchmayer, Belleudi Valeria, Marco Finocchietti, Francesco Barone‐Adesi, Giuseppe Roberto   +21 more
wiley   +1 more source

Chemotherapy‐driven expression of WNT ligands in bone marrow stromal cells contributes to chemoresistance in acute lymphoblastic leukaemia

British Journal of Haematology, Volume 208, Issue 5, Page 1572-1583, May 2026.
Chemotherapy‐induced WNT ligand secretion by bone marrow (BM) stroma drives acute lymphoblastic leukaemia (ALL) chemoresistance. WNT pathway inhibition disrupts this cross‐talk and restores therapeutic response, highlighting WNT inhibitors as a promising strategy to prevent relapse in ALL.
Foteini Kalampalika, Amanda Jiménez‐Pompa, Raúl Sánchez‐Lanzas, Bela Patel, Miguel Ganuza   +4 more
wiley   +1 more source

PURIFICATION AND IMMOBILIZATION OF L-ASPARAGINASE ENZYME FROM THE THERMOPHILIC BACTERIA Bacillus licheniformis STRAIN HSA3-1a [PDF]

L-Asparaginase gives a great benefit in the cancer treatment, especially in acute\ud lymphoblastic leukemia. L-Asparaginase is also proven to reduce the acrylamide\ud content in the foods.
Ahmad, Ahyar
core   +3 more sources

Three Distinct Species Cause Bacterial Leaf Spots in ‘Ubá’ Mango in Zona da Mata, Minas Gerais, Brazil

Journal of Phytopathology, Volume 174, Issue 3, May/June 2026.
ABSTRACT ‘Ubá’ mango is a fruit crop of great value for farmers in the Zona da Mata region of Minas Gerais state, Brazil. Organic farmers from this region recently reported a severe outbreak of foliar black spots of unknown aetiology in orchards of this mango variety, causing significant concern.
Nikolas Emanuel Chaves‐Silva, Adryelle Anchieta Sousa, Sandro Lúcio Silva Moreira, Camila Mota De Assis Figueiredo, Cleverson Vieira Pires, Mateus Pereira Gonzatto, Alex Gazolla de Castro, Marcos Rogério Tótola, Jorge Luis Badel   +8 more
wiley   +1 more source

Produção da enzima antileugêmica L-Asparaginase II a partir da clonagem do Gene ErA de Erwinia Carotovora Supsp. Atroseptica em Escherichia Coli [PDF]

, 2009
As enzimas L-asparaginase do tipo II catalisam a hidrólise de L-asparagina a Laspartato e amônia e, em menor quantidade, a hidrólise de L-glutamina. Escherichia coli e Erwinia chrysanthemi são as principais origens das L-asparaginases II utilizadas como ...
Wink, Priscila Lamb
core  

Screening of Bacteria Producing Asparaginase Free of Glutaminase and Urease from Hot Springs in West Sulawesi

Biosaintifika: Journal of Biology & Biology Education, 2019
L-asparaginase catalyzes the hydrolysis of asparagine into ammonia and aspartate. It has been used in chemotherapy for patients with acute lymphoblastic leukemia. L-asparaginase presents in animal, plant and microorganism.
Ruby Setiawan, Dinar Rahmi Larasati
doaj   +1 more source

Production of L-asparaginase from Natural Substrates by Escherichia coli ATCC 10536 and Comparison of Physiology Parameters [PDF]

, 2016
High demand of L-asparaginase urges the researchers to maximize the production of this enzyme with affordable cost in short period of time. Microbial fermentation is an alternative source for production of L-asparaginase enzyme due to its low cost, easy
Batool, Tahira, Chia, Vi Vien, M. M., Yusoff, Makky, Essam A., Nina Suhaity, Azmi   +4 more
core  

L-asparaginase induces IP3R-mediated ER Ca2+ release by targeting µ-OR1 and PAR2 and kills acute lymphoblastic leukemia cells

Cell Death Discovery
L-asparaginase is a standard therapeutic option for acute lymphoblastic leukemia (aLL), a hematologic cancer that claims the most lives of pediatric cancer patients.
Jung Kwon Lee, Hamza Kamran, Ki-Young Lee   +2 more
doaj   +1 more source

PKA inhibition kills l-asparaginase-resistant leukemic cells from relapsed acute lymphoblastic leukemia patients

Cell Death Discovery
Despite the success in treating newly diagnosed pediatric acute lymphoblastic leukemia (aLL), the long-term cure rate for the 20% of children who relapse is poor, making relapsed aLL the primary cause of cancer death in children.
Jung Kwon Lee, Xidi Wang, Jinghua Wang, Jesusa L. Rosales, Ki-Young Lee   +4 more
doaj   +1 more source