Results 121 to 130 of about 15,191 (179)

Age-based pegaspargase dosing is safe and achieves therapeutic levels in infants with ALL: report from COG AALL15P1. [PDF]

open access: yesBlood Adv
Faulk KE   +14 more
europepmc   +1 more source

Asparaginase Revisited

Leukemia and Lymphoma, 1993
R L Capizzi, Robert L Capizzi
exaly   +3 more sources

PEG-asparaginase

Expert Opinion on Pharmacotherapy, 2007
L-asparaginases have been established components in the treatment of acute leukemias for nearly 40 years. Their antitumor effect results from the depletion of asparagine, an amino acid essential to leukemic cells, and subsequent inhibition of protein synthesis leading to considerable cytotoxicity.
Cecilia H, Fu, Kathleen M, Sakamoto
openaire   +2 more sources

Asparaginase revisited

Leukemia & Lymphoma, 2011
Asparaginase is one of the main drugs used to treat acute lymphoblastic leukemia and certain non-Hodgkin lymphomas. The drug is a bacterial product, and this results in differences in activity, efficacy, and side effects among the various marketed products. Native products originate from either Escherichia coli or Erwinia chrysanthemi.
openaire   +2 more sources

[Pharmacokinetics and Bioequiavailability of Asparaginase in Asparaginase Nanospheres].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2016
To determine the pharmacokinetics and bioequivalence of self-assembled hyaluronic acid-graft-poly (ethylene glycol)/hydroxypropyl-beta-cyclodextrin hollow nanospheres loaded with asparaginase (AHHPs) in SD rats.AHHPs were prepared and observed under transmission electron microscopy.
Zi-jun, Yan   +5 more
openaire   +1 more source

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