Results 81 to 90 of about 30,573 (214)
Pharmacokinetic and clinical considerations for monitoring asparaginase activity levels during pegaspargase therapy [PDF]
, 2015 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111166/1/pbc25426 ...
Benitez, Lydia +3 more
core +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack +39 more
wiley +1 more source
Results of successive EORTC-CLG 58 881 and 58 951 trials in paediatric T-cell acute lymphoblastic leukaemia (ALL) [PDF]
, 2019 Outcomes in childhood T-cell acute lymphoblastic leukaemia (T-ALL) are steadily improving due to intensive therapy. Between 1989 and 2008, 599 children with newly diagnosed T-ALL were enrolled in two successive European Organization for Research and ...
Bertrand, Yves +22 more
core +4 more sources
eFood, Volume 7, Issue 3, June 2026.This review highlights the formation of foodborne carcinogens during processing and evaluates different mitigation strategies, including natural antioxidants and modern cooking techniques, to reduce associated cancer risks and enhance food safety. ABSTRACT Food processing methods, though vital for improving food safety, taste, and shelf life, can ...
Naglaa S. Ashmawy +4 more
wiley +1 more source
Asparaginase Potentiates Glucocorticoid-Induced Osteonecrosis in a Mouse Model.
PLoS ONE, 2016 Osteonecrosis is a common dose-limiting toxicity of glucocorticoids. Data from clinical trials suggest that other medications can increase the risk of glucocorticoid-induced osteonecrosis.
Chengcheng Liu +8 more
doaj +1 more source
Solid-phase enzyme modification via affinity chromatography [PDF]
, 2003 In the present study antileukemic enzyme L-asparaginase (ASNase) and catalase (as a model enzyme) were modified in solid-phase with activated polyethylene glycol (PEG ) by using ligand-immobilized affinity column systems L-asparagine- 2 Sepharose CL-4B
Aebi +32 more
core +1 more source
eJHaem, Volume 7, Issue 3, June 2026.ABSTRACT Peripheral T‐cell lymphomas (PTCLs) are heterogeneous neoplasms with poor prognosis and marked geographic variation. Data from Taiwan remain limited. We conducted a 15‐year retrospective cohort study of 249 patients diagnosed with PTCL at two major centers in southern Taiwan between 2010 and 2024 to characterize regional epidemiology, real ...
Bo‐Yu Huang +9 more
wiley +1 more source
Role of L-asparaginase in acute lymphoblastic leukemia: focus on adult patients
Blood and Lymphatic Cancer: Targets and Therapy, 2012 Michael E RyttingDepartment of Pediatrics and Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USAAbstract: Asparaginase preparations deplete asparagine in acute lymphoblastic leukemia (ALL) blasts.
Rytting ME
doaj
Optimization of asparaginase production from Zymomonas mobilis by continuous fermentation
Acta Scientiarum: Biological Sciences, 2016 Asparaginase is an enzyme used in clinical treatments as a chemotherapeutic agent and in food technology to prevent acrylamide formation in fried and baked foods.
Francieli Bortoluzzi Menegat +3 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 12, Page 3355-3376, June 2026.Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire +28 more
wiley +1 more source