Results 31 to 40 of about 11,688 (172)

Impact of the Disruption of ASN3-Encoding Asparagine Synthetase on Arabidopsis Development

Agronomy, 2016
The aim of this study was to investigate the role of ASN3-encoded asparagine synthetase (AS, EC 6.3.5.4) during vegetative growth, seed development and germination of Arabidopsis thaliana. Phenotypic analysis of knockout (asn3-1) and knockdown (asn3-2) T-
Laure Gaufichon, Anne Marmagne, Tadakatsu Yoneyama, Toshiharu Hase, Gilles Clément, Marion Trassaert, Xiaole Xu, Maryam Shakibaei, Amina Najihi, Akira Suzuki   +9 more
doaj   +1 more source

Genomic, Biochemical, and Modeling Analyses of Asparagine Synthetases from Wheat

Frontiers in Plant Science, 2018
Asparagine synthetase activity in cereals has become an important issue with the discovery that free asparagine concentration determines the potential for formation of acrylamide, a probably carcinogenic processing contaminant, in baked cereal products ...
Hongwei Xu, Hongwei Xu, Tanya Y. Curtis, Stephen J. Powers, Sarah Raffan, Runhong Gao, Runhong Gao, Jianhua Huang, Monika Heiner, David R. Gilbert, Nigel G. Halford   +10 more
doaj   +1 more source

In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia

Haematologica, 2022
Asparagine is a non-essential amino acid since it can either be taken up via the diet or synthesized by asparagine synthetase. Acute lymphoblastic leukemia (ALL) cells do not express asparagine synthetase or express it only minimally, which makes them ...
Maaike Van Trimpont, Amanda M. Schalk, Yanti De Visser, Hien Anh Nguyen, Lindy Reunes, Katrien Vandemeulebroecke, Evelien Peeters, Ying Su, Hyun Lee, Philip L. Lorenzi, Wai-Kin Chan, Veerle Mondelaers, Barbara De Moerloose, Tim Lammens, Steven Goossens, Pieter Van Vlierberghe, Arnon Lavie   +16 more
doaj   +1 more source

Contrasting gene expression patterns in grain of high and low asparagine wheat genotypes in response to sulphur supply

BMC Genomics, 2019
Background Free asparagine is the precursor for acrylamide formation during cooking and processing of grains, tubers, beans and other crop products. In wheat grain, free asparagine, free glutamine and total free amino acids accumulate to high levels in ...
Tanya Y. Curtis, Sarah Raffan, Yongfang Wan, Robert King, Asier Gonzalez-Uriarte, Nigel G. Halford   +5 more
doaj   +1 more source

Assimilation of Nitrate into Asparagine for Transport in Soybeans

Agronomy, 2023
In this study, the systematic analysis of nitrate assimilation and transport in soybean roots was further improved by analyzing the concentrations of nitrate assimilates, asparagine and glutamine, in soybean roots and the related enzyme activities.
Sha Li, Xiaochen Lyu, Xuelai Wang, Shuhong Zhao, Chunmei Ma, Chao Yan, Zhenping Gong   +6 more
doaj   +1 more source

Genes for asparagine metabolism in Lotus japonicus: differential expression and interconnection with photorespiration

BMC Genomics, 2017
Background Asparagine is a very important nitrogen transport and storage compound in plants due to its high nitrogen/carbon ratio and stability. Asparagine intracellular concentration depends on a balance between asparagine biosynthesis and degradation ...
Margarita García-Calderón, Carmen M. Pérez-Delgado, Alfredo Credali, José M. Vega, Marco Betti, Antonio J. Márquez   +5 more
doaj   +1 more source

Asparagine synthetase: Function, structure, and role in disease [PDF]

Journal of Biological Chemistry, 2017
Asparagine synthetase (ASNS) converts aspartate and glutamine to asparagine and glutamate in an ATP-dependent reaction. ASNS is present in most, if not all, mammalian organs, but varies widely in basal expression. Human ASNS activity is highly responsive to cellular stress, primarily by increased transcription from a single gene located on chromosome 7.
Carrie L, Lomelino, Jacob T, Andring, Robert, McKenna, Michael S, Kilberg   +3 more
openaire   +2 more sources

Nitrogen assimilation in Citrus based on CitEST data mining

Genetics and Molecular Biology, 2007
Assimilation of nitrate and ammonium are vital procedures for plant development and growth. From these primary paths of inorganic nitrogen assimilation, this metabolism integrates diverse paths for biosynthesis of macromolecules, such as amino acids and ...
Ester Wickert, Jackson Marcondes, Manoel Victor Lemos, Eliana G.M. Lemos   +3 more
doaj   +1 more source

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

Cell Death and Disease, 2021
Asparaginase depletes extracellular asparagine in the blood and is an important treatment for acute lymphoblastic leukemia (ALL) due to asparagine auxotrophy of ALL blasts.
Sophia Ceder, Sofi E. Eriksson, Ying Yu Liang, Emarndeena H. Cheteh, Si Min Zhang, Kenji M. Fujihara, Julie Bianchi, Vladimir J. N. Bykov, Lars Abrahmsen, Nicholas J. Clemons, Pär Nordlund, Sean G. Rudd, Klas G. Wiman   +12 more
doaj   +1 more source

Asparagine Synthesis During Tobacco Leaf Curing

Plants, 2019
Senescence is a genetically controlled mechanism that modifies leaf chemistry. This involves significant changes in the accumulation of carbon- and nitrogen-containing compounds, including asparagine through the activity of asparagine synthetases.
Lucien Bovet, Cecilia Cheval, Aurore Hilfiker, James Battey, Delphine Langlet, Herve Broye, Joanne Schwaar, Pierrick Ozelley, Gerhard Lang, Nicolas Bakaher, Helene Laparra, Simon Goepfert   +11 more
doaj   +1 more source