Results 51 to 60 of about 11,688 (172)

Asparagine protects pericentral hepatocytes during acute liver injury

The Journal of Clinical Investigation, 2023
The nonessential amino acid asparagine can only be synthesized de novo by the enzymatic activity of asparagine synthetase (ASNS). While ASNS and asparagine have been implicated in the response to numerous metabolic stressors in cultured cells, the in ...
Yu Sun, Hadrien Demagny, Adrien Faure, Francesca Pontanari, Antoine Jalil, Nadia Bresciani, Ece Yildiz, Melanie Korbelius, Alessia Perino, Kristina Schoonjans   +9 more
doaj   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Asparagine Metabolism in Tumors Is Linked to Poor Survival in Females with Colorectal Cancer: A Cohort Study

Metabolites, 2022
The interplay between the sex-specific differences in tumor metabolome and colorectal cancer (CRC) prognosis has never been studied and represents an opportunity to improve patient outcomes.
Xinyi Shen, Yuping Cai, Lingeng Lu, Huang Huang, Hong Yan, Philip B. Paty, Engjel Muca, Nita Ahuja, Yawei Zhang, Caroline H. Johnson, Sajid A. Khan   +10 more
doaj   +1 more source

Synthetic biology approaches to generate temperature‐sensitive alleles for the Sterile Insect Technique

Insect Science, EarlyView.
Abstract The Sterile Insect Technique (SIT) is an environmentally friendly, sustainable pest control approach, which uses large‐scale releases of sterile insects to suppress or eradicate target populations through infertile matings. The efficiency of SIT is enhanced by male‐only releases requiring genetic sexing strains (GSSs) that are classically ...
Chun Yin Leung, Ernst A. Wimmer, Hassan M. M. Ahmed   +2 more
wiley   +1 more source

Nitrogen remobilization and its importance in nitrogen use efficiency (NUE) of crops

The Indian Journal of Agricultural Sciences, 2021
Nitrogen (N) remobilization during grain filling from pre-anthesis N uptake and stored in different tissues of crop N use efficiency (NUE). N is remobilized from to sink (young leaves or grains) with the help of nitrate/amino acid transporters. Nearly 80%
BIRENDRA KUMAR PADHAN, LEKSHMY SATHEE, VANITA JAIN   +2 more
doaj   +1 more source

The Efficacy of Food‐Grade Substances to Protect Dietary Glutamine From Ruminal Degradation

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT This study was conducted to investigate the use of four, low cost, food‐grade substances to protect glutamine from microbial degradation in vitro, and subsequently validate their efficacy in vivo. Two in vitro trials were conducted using 250 mL bottles replicated in triplicate to test beeswax‐, paraffin wax‐, zein‐, and rice bran wax ...
Lillian P. Carlyon, Tianna R. Boyce, Leesa‐Joy Dunstan, Bruno R. C. Alves, Kiro Petrovski, Mariana Caetano   +5 more
wiley   +1 more source

LRH-1 induces hepatoprotective nonessential amino acids in response to acute liver injury

The Journal of Clinical Investigation, 2023
Acute hepatic injury is observed in response to various stressors, including trauma, ingestion of hepatic toxins, and hepatitis. Investigations to date have focused on extrinsic and intrinsic signals required for hepatocytes to proliferate and regenerate
Kevin C. Klatt, Elizabeth J. Petviashvili, David D. Moore   +2 more
doaj   +1 more source

Comparative analysis of canonical and noncanonical rhodopsins in Amphidinium carterae and Karlodinium veneficum

Journal of Phycology, EarlyView.
Abstract Rhodopsins are ancient and versatile light‐sensitive proteins, widely distributed across microbial life. In dinoflagellates, however, their diversity and function remain poorly understood, owing to the lineage's extreme genomic divergence. Here, we surveyed the rhodopsin complements of two dinoflagellates, Amphidinium carterae and Karlodinium ...
Jens Wira, Miranda Judd, Anne Baldino, Tsvetan Bachvaroff, Allen R. Place   +4 more
wiley   +1 more source

The MdICE1/MdFAMA‐MdTYDC Transcriptional Module Confers Cold Tolerance by Regulating Dopamine Metabolism in Apple

Plant Biotechnology Journal, EarlyView.
ABSTRACT Low temperature is a critical abiotic stress that imposes major constraints on the sustainable development of the fruit tree industry. Although exogenous dopamine has been shown to enhance cold tolerance in plants, its molecular mechanisms in apple (Malus domestica) remain poorly understood.
Kexin Tan, Xinyang Song, Ziyi Xu, Hongzhen Zhu, Ying Zhang, Shuhan Xu, Zhijun Zhang, Pengmin Li, Fengwang Ma, Chao Li   +9 more
wiley   +1 more source