Results 71 to 80 of about 11,688 (172)

Directed Functionalization of Recombinant Spider Silk Nonwoven Membranes with Antibodies Using Non‐Canonical Amino Acids

Advanced Materials, Volume 38, Issue 14, 6 March 2026.
A recombinant spider silk protein was functionalized by incorporating genetically encoded bio‐orthogonal reactive azido‐groups. The azido‐functionalized proteins were produced in a scalable biotechnological process, and particles, films, as well as nanofibers were established as anchorage for fully functional antibodies via site‐specific bio‐orthogonal
Claudia Lacombe, Charlotte Leonhardt, Martin Humenik, Birgit Wiltschi, Thomas Scheibel   +4 more
wiley   +1 more source

Molecular structure of the human asparagine synthetase gene

Genomics, 1989
The human gene for asparagine synthetase has been isolated and the molecular organization has been determined by mapping and DNA sequencing of intron-exon boundaries. The gene spans 35 kb and contains 13 exons. The structure of the human gene has a high degree of similarity to that of the hamster asparagine synthetase gene, with identical positions for
Y P, Zhang, M A, Lambert, A E, Cairney, D, Wills, P N, Ray, I L, Andrulis   +5 more
openaire   +2 more sources

Asparagine Synthetase Deficiency: New Inborn Errors of Metabolism [PDF]

, 2015
Asparagine synthetase deficiency (ASD) is a newly identified neurometabolic disorder characterized by severe congenital microcephaly, severe global developmental delay, intractable seizure disorder, and spastic quadriplegia. Brain MRI showed brain atrophy, delayed myelination, and simplified gyriform pattern.We report ASD deficiency in a 2- and 4-year ...
Majid, Alfadhel, Muhammad Talal, Alrifai, Daniel, Trujillano, Hesham, Alshaalan, Ali, Al Othaim, Shatha, Al Rasheed, Hussam, Assiri, Abdulrhman A, Alqahtani, Manal, Alaamery, Arndt, Rolfs, Wafaa, Eyaid   +10 more
openaire   +2 more sources

The multifaceted roles of the ACSL family in cancer: Metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
The acyl‐CoA synthetase long‐chain (ACSL) family consists of five members, which exhibit a synergistic effect in promoting tumour lipid metabolism for energy supply. Specifically, ACSL3 and ACSL4 have antagonistic effects on the mechanisms related to ferroptosis in tumour cells.
Haocai Li, Weijian Wang, Juncheng Zhan, Yuxiang Xiao, Xiaoping Chen, Chen Su, Peng Zhu   +6 more
wiley   +1 more source

Metabolite and light regulation of metabolism in plants: lessons from the study of a single biochemical pathway

Brazilian Journal of Medical and Biological Research, 2001
We are using molecular, biochemical, and genetic approaches to study the structural and regulatory genes controlling the assimilation of inorganic nitrogen into the amino acids glutamine, glutamate, aspartate and asparagine.
I.C. Oliveira, E. Brenner, J. Chiu, M.-H. Hsieh, A. Kouranov, H.-M. Lam, M.J. Shin, G. Coruzzi   +7 more
doaj   +1 more source

Marine n‐3 Polyunsaturated Fatty Acids Mitigate Obesity Traits Through PRDM16‐Driven Gene–Nutrient Interaction and Spatiotemporal Scale Browning Process

Food Frontiers, Volume 7, Issue 2, March 2026.
This large cohort study of 45,664 participants from the UK Biobank provides strong epidemiological evidence that fish oil use was associated with 12% and 7% lower risks of obesity and high body fat percentage, respectively. Mechanistically, marine n‐3 polyunsaturated fatty acids mitigate obesity traits through PRDM16‐driven gene–nutrient interactions ...
Xiaohui Liu, Haoyu Li, Youyou Zheng, Xiaoqian Chen, Xuzhi Wan, Pan Zhuang, Wei Jia, Jianxin Yao, Haoyin Liu, Hongbo Shi, Xunan Lin, Yu Zhang, Jingjing Jiao   +12 more
wiley   +1 more source

Effects of Probiotic Supplementation on Symptoms and Microbiome Characteristics in Patients With Non‐Celiac Gluten/Wheat Sensitivity: A Randomized Controlled Double‐Blind Trial

Food Frontiers, Volume 7, Issue 2, March 2026.
This randomized, double‐blind, placebo‐controlled trial demonstrated that probiotic supplementation in individuals with non‐celiac gluten/wheat sensitivity improved tolerance to gluten reintroduction in nearly half of participants. The effect was associated with beneficial shifts in gut microbiome composition and function, including enhanced microbial ...
Ilario Ferrocino, Valentina Ponzo, Ilaria Goitre, Fulvia Trapani, Chiara Emilia Cordero, Enrica Favaro, Sergio Riso, Fabio Dario Merlo, Lucia Fransos, Fulvia Marengo, Mauro Bruno, Andrea Evangelista, Luca Cocolin, Ezio Ghigo, Simona Bo   +14 more
wiley   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Untargeted Metabolomics Reveals Organ‐Specific and Extraction‐Dependent Metabolite Profiles in Endemic Tajik Species Ferula violacea Korovin

Plant Direct, Volume 10, Issue 3, March 2026.
ABSTRACT Ferula violacea Korovin, an endemic Tajikistani plant with purported medicinal properties, remains understudied. This study employs untargeted metabolomics to characterize the metabolite profiles of ethanol extracts and juices from F. violacea roots and seeds.
Sylhiya Mavlonazarova, Kenneth Acosta, Rinat Abzalimov, Saidbeg Satorov, Vyacheslav Dushenkov   +4 more
wiley   +1 more source

Efficient Extracellular Production of Insulin Glargine in Trichoderma reesei by an Integrative Secretion‐Based Strategy

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
Schematic diagram showing how optimisation of the expression cassette enhances secretory production of insulin Glargine. ABSTRACT Insulin glargine, a long‐acting insulin analog, is essential for diabetes treatment. However, its industrial production remains challenging due to limitations in conventional expression systems.
Aiqin Yan, Xihai Li, Di Zhang, Lunbo Li, Jinfeng Liu, Xuejian Si, Kewen Li, Qingmin Luan, Hong Liu, Yaohua Zhong   +9 more
wiley   +1 more source