A New Highly Concentrated Insulin Aspart AT278 (500 U/mL) Demonstrates Ultra‐Rapid Pharmacokinetic and Pharmacodynamic Properties in Type 2 Diabetes Regardless of BMI [PDF]
Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9423-9432, October 2026.ABSTRACT Aims To evaluate the pharmacokinetics, pharmacodynamics, and safety of a novel U500 insulin aspart formulation (AT278 [500 U/mL]; AT278‐U500) compared with standard concentration insulin aspart (InsAsp [100 U/mL]; InsAsp‐U100) and U500 human regular insulin (HumIns [500 IU/mL]; HumIns‐U500). Materials and Methods This single‐centre, randomised,
Eva Svehlikova +11 more
wiley +2 more sources
Efficacy and Hypoglycaemia Outcomes With Once‐Weekly IcoSema Versus Comparators in Individuals With Type 2 Diabetes by Kidney and Liver Function: A Post Hoc Analysis of the COMBINE 1–3 Trials [PDF]
Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9607-9620, October 2026.ABSTRACT Aims This post hoc analysis of COMBINE 1–3 assessed efficacy and hypoglycaemia outcomes with IcoSema (once‐weekly combination therapy of basal insulin icodec and semaglutide [a glucagon‐like peptide‐1 analogue]) versus comparators in adults with type 2 diabetes (T2D) by kidney and liver function subgroups.
Linong Ji +6 more
wiley +2 more sources
Efficacy and Safety of iGlarLixi Versus IDegAsp by Baseline Age, Disease Duration and HbA1c in Chinese People With Type 2 Diabetes: Post Hoc Analyses of the Soli‐D Study [PDF]
Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9091-9100, October 2026.ABSTRACT Aims To compare the efficacy and safety of insulin glargine 100 U/mL plus lixisenatide (iGlarLixi) with insulin degludec plus insulin aspart (IDegAsp) by baseline age, Type 2 diabetes (T2D) duration and glycated haemoglobin (HbA1c) in the Soli‐D study.
Saichun Zhang +14 more
wiley +2 more sources
Giant abdominal hematoma from injection into an insulin ball during dual antithrombotic and corticosteroid therapy [PDF]
J Diabetes InvestigJournal of Diabetes Investigation, EarlyView.
Yasuhiro Tanji +3 more
wiley +2 more sources
Comparison of the effectiveness of fast-acting insulin aspart with rapid-acting insulin analogues on glycaemic control: a retrospective cohort study using patient data from primary care practices in England [PDF]
BMJ OpenObjectives This study compared the effectiveness of first-time use of faster aspart with rapid-acting insulin analogues in patients with type 1 diabetes (T1D) or type 2 diabetes (T2D).Design, setting This retrospective cohort study used data from 1 ...
Melanie J Davies +6 more
doaj +2 more sources
Incidental Colonic Pneumatosis Intestinalis With Pneumoperitoneum Managed Conservatively [PDF]
Clinical Case Reports, Volume 14, Issue 8, August 2026.ABSTRACT Pneumoperitoneum accompanying pneumatosis intestinalis can mimic intestinal perforation but does not always require surgery. In asymptomatic, hemodynamically stable patients without high‐risk CT features, conservative management with careful observation and medication review may help avoid unnecessary laparotomy.
Takuya Omura, Tsukasa Aritake
wiley +2 more sources
Fast-acting insulin aspart - from insulin portraits to patient portraits
Медицинский совет, 2021 Postprandial hyperglycemia is an independent risk factor for cardiovascular disease (CVD). Bolus insulins aim to mimic the physiological action of endogenous insulin secreted in response to food intake to control peaks of postprandial glycemia (PPG ...
T. Yu. Demidova, M. Ya. Izmaylova
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A Comparison of the Efficacy of Insulin Aspart and Regular Insulin for Managing Gestational Diabetes and their Effects on Delivery Outcomes [PDF]
Journal of Midwifery & Reproductive Health, 2021 Background & aim: Rapid-acting insulin analogs, such as insulin aspart, are used in type 1 and type 2 diabetes in pregnancy, and are approved for using in gestational diabetes mellitus (GDM).
Parichehr Pooransari +3 more
doaj +1 more source
Optimisation of induction conditions for a bacterial strain producing proinsulin aspart
Биопрепараты: Профилактика, диагностика, лечение, 2023 Diabetes poses a serious threat to the health of people around the world. Therefore, in 2021, the World Health Organisation launched the Global Diabetes Compact, an initiative aimed at improving the management and prevention of diabetes. The rapid growth
I. A. Kornakov +5 more
doaj +1 more source
Сахарный диабет, 2020 Fast-acting insulin aspart (faster aspart) is insulin aspart (IAsp) with two added excipients, L-arginine and niacinamide, to ensure formulation stability with accelerated initial absorption after subcutaneous administration compared with previously ...
Hanne Haahr, Tim Heise
doaj +1 more source