Results 41 to 50 of about 85,064 (291)
Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito +8 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical FI. Methods We used data from a single‐center prospective cohort of adult patients with SLE whose baseline visit ...
Grace Burns +2 more
wiley +1 more source
Aminotransferases: demonstration of homology and division into evolutionary subgroups.
, 1993 A total of 150 amino acid sequences of vitamin B6-dependent enzymes are known to date, the largest contingent being furnished by the aminotransferases with 51 sequences of 14 different enzymes.
Hale TI, Mehta PK, Christen P
core +1 more source
Arthritis Care &Research, EarlyView.Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel +6 more
wiley +1 more source
Effect of Temperature and storage time on Hepatobiliary enzyme activities in Goat serum [PDF]
Veterinary World, 2010 The present study was designed and conducted to choose an ideal storage condition for goat sera samples meant for the assay of hepatobiliary enzymes such as, alanine aminotransferases(ALT), aspartate aminotransferases (AST), alkaline phosphatase (ALP ...
P.D. Divya and K.K. Jayavardhanan
doaj
Arthritis Care &Research, EarlyView.Objective To evaluate whether extending the American College of Rheumatology–recommended monitoring interval for complete blood count and liver function tests in patients receiving methotrexate (MTX) affects timely detection of medication‐related toxicity.
Spencer Simko +4 more
wiley +1 more source
BMC Endocrine Disorders, 2019 Background Abnormal levels of liver enzymes, particularly aminotransferases, are prognostic features of non-alcoholic fatty liver disease (NAFLD). Considering the important role of dietary intakes in development of NAFLD, we aimed to determine possible ...
Parvin Mirmiran +3 more
doaj +1 more source
A systematic review and meta-analysis of the COVID-19 associated liver injury
Annals of Hepatology, 2020 Introduction and Objectives: The novel coronavirus disease 2019 (COVID-19) has affected more than 5 million people globally. Data on the prevalence and degree of COVID-19 associated liver injury among patients with COVID-19 remain limited. We conducted a
Yu Jun Wong +7 more
doaj +1 more source
Pretreatment of hepatetctomized rats with Coleus forskohlii did not interfere with the course of hepatic hyperplasia [PDF]
Acta Cirúrgica Brasileira, 2019 Purpose Coleus forskohlii Briq., a medicinal plant originally from India, has been indicated against heart disease, expiratory disorders, convulsions, and hepatic changes, among others.
Pedro Paulo Barros +3 more
doaj +1 more source
Primary Human Immunodeficiency Virus Infection Presenting as Elevated Aminotransferases [PDF]
, 2010 Background/PurposePrimary human immunodeficiency virus type 1 (HIV-1) infection is often under-diagnosed because of its nonspecific presentations. Elevated aminotransferase levels is one of its clinical manifestations, but is infrequently reported in the
Yi-Jan Chen +9 more
core +1 more source