Results 241 to 250 of about 471,402 (314)

Oxaliplatin-induced autoimmune-like hepatitis: A case report highlighting the role of clinical pharmacists. [PDF]

Biomed Rep
Zeng X, Liu T, Jin G.
europepmc   +1 more source

In Situ Bioorthogonal Synthesis of PROTACs via Dual‐Responsive Cleavage for Synergistic Photo‐Immunotherapy

Advanced Science, EarlyView.
A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian, Jiasha Wu, Fusheng Xu, Yan Zuo, Huaxing Shen, Rui Ji, Luyi Wang, Na Li, Yanting Sun, Yongsheng Yu, Yejiao Shi, Honggang Hu, Feng Xu, Dan Huang, Xiaochun Hu   +14 more
wiley   +1 more source

Single-Dose Nivolumab as a Trigger of Myocarditis, Myositis, and Myasthenia Gravis Overlap Syndrome With Late Cardiac Death Despite Initial Recovery: A Case Report. [PDF]

Am J Case Rep
Beereddy D, Jonnalagadda DNMR, Mandal S, Zhang J.   +3 more
europepmc   +1 more source

Association between serum anion gap and 28-day mortality among patients admitted to the hospital with aortic dissection: a retrospective cohort study with the MIMIC-IV database. [PDF]

J Thorac Dis
Chen KY, Lei J, Yang X, Zheng LZ, Tian Y, Qiu ZH, Chen LW.   +6 more
europepmc   +1 more source

Stimulation of OGG1 Enhances Oxidative DNA Damage Repair and Protects Against Acute Liver Failure by Acetaminophen

Advanced Science, EarlyView.
Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao, Rahul Upadhyay, Alice Eddershaw, Chenchen Wang, Yudong Zhao, Olov Wallner, Jinhye Ryu, Nayere Taebnia, Heather Gildie, Emma Scaletti‐Hutchinson, Jonathan R. Davies, Nicole Ziegler, Andreas Krämer, Samantha C. Robinson, Marek Varga, Karolina Singerova, Zuzanna Szaruga, Elisée Wiita, İrşil Güneş, Sheila S. David, Stefan Knapp, Aimo Kannt, Miguel de Vega, Pål Stenmark, Volker M Lauschke, Maurice Michel   +25 more
wiley   +1 more source

Patients on statins with elevated transaminases: Frequency of follow-up creatine kinase testing and gastroenterology referral. [PDF]

Br J Clin Pharmacol
Shweikeh F, Kartoumah A, Joshi R, Nadihaan A, Mouchli M, Singh I.   +5 more
europepmc   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Olanzapine induced hepatotoxicity in a young female with psychosis. [PDF]

Ind Psychiatry J
Wayal P, Ramawat RB, Afroz O, Patil V, Sood M.   +4 more
europepmc   +1 more source

Japanese encephalitis virus reprograms host pyrimidine metabolism to facilitate viral replication. [PDF]

Infect Med (Beijing)
Gu J, Fan C, Xiang S, Si Y, Zhu B, Cao S, Ye J.   +6 more
europepmc   +1 more source

Fueling the fire: aspartate deficiency primes and fuels STING activation. [PDF]

J Clin Invest
Jiang H, Wang W, Fu YX.
europepmc   +1 more source