Results 51 to 60 of about 36,613 (150)

Black Sheep: Pseudokinases Bucking the Trend to Reveal Non‐Catalytic Kinase Functions

IUBMB Life, Volume 78, Issue 8, August 2026.
ABSTRACT Pseudokinases are the catalytically‐dead counterparts of protein kinases and, over the past 20 years, have increasingly garnered attention as crucial signaling entities—comprehensively dispelling the possibility that they are merely evolutionary remnants or cellular passengers.
James M. Murphy, Natalia Jura, Peter D. Mace   +2 more
wiley   +1 more source

Pro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pH. [PDF]

, 2002
BACKGROUND: One of the signatures of Alzheimer's disease is the accumulation of aggregated amyloid protein, Abeta, in the brain. Abeta arises from cleavage of the Amyloid Precursor protein by beta and gamma secretases, which present attractive candidates
Brian Austen, Liu, C, Austen, B, Chibuu Liu, Sidera, C, Christina Sidera   +5 more
core   +1 more source

Aerobic Endurance Training Modulates Cardiac Renin‐Angiotensin System Peptides and Matrix Metalloproteinase Activity During Chronic Stress

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT To investigate the involvement of metalloproteinases (MMPs) in the context of endurance training and their interactions with renin‐angiotensin signalling (RAS) in stress‐induced pathophysiological responses. Trained rats were submitted to 8‐weeks of endurance treadmill training with chronic mild stress (CMS), TS rats, and without CMS (T).
Vinicius Guzzoni, Fabiana Gomes Ferreira, Lívia Bruni de Souza, Rebecca Salomão, Nicholas Kesler, Rodrigo Yokota, Nilsa Regina Damaceno‐Rodrigues, Elia Garcia Caldini, Fernanda Klein Marcondes, Rita de Cássia Marqueti, Steven T. Haller, David J. Kennedy, Lauren G. Koch, Dulce Elena Casarini, Tatiana Sousa Cunha   +14 more
wiley   +1 more source

Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo [PDF]

, 2003
Mammalian asparaginyl endopeptidase (AEP) or legumain is a recently discovered lysosomal cysteine protease that specifically cleaves after asparagine residues.
Watts, Colin, Matthews, Stephen P., Antoniou, Antony N., Mazzeo, Daniela, Li, Dongtao Ni   +4 more
core   +1 more source

Evaluation of disease resistance in intermediate wheatgrass and genome‐wide association for fusarium head blight‐related traits

Crop Science, Volume 66, Issue 4, July/August 2026.
Abstract Intermediate wheatgrass (IWG) [Thinopyrum intermedium (Host) Barkworth & D. R. Dewey] is a promising perennial grain candidate that The Land Institute has been directly domesticating since 2001. Grain from improved IWG can be sold under the trademark Kernza.
Leah K. Treffer, Jared Crain, Steve R. Larson, Yvonne A. Thompson, M. Kathryn Turner   +4 more
wiley   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, Volume 293, Issue 13, Page 3758-3787, July 2026.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Bacterial aspartic proteinases [PDF]

, 1997
Regions of genomic DNA encoding putative aspartic proteinase domains were amplified by PCR from the bacterial species, Escherichia coli and Haemophilus influenzae.
Jeffrey Hill, Phylip, Lowri H, Hill, Jeffrey, Lowri H Phylip   +3 more
core   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Racemisation of Amino Acids: From Synthetic Challenge to Biological Significance

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Racemisation, once considered an undesirable synthetic side reaction, also occurs naturally in amino acids and influences biological processes. Evidence links stereochemical conversion to ageing, protein turnover, and cellular development. This review examines mechanisms, control strategies in synthesis, applications and implications in physiology ...
Othman Al Musaimi
wiley   +1 more source

Hemoglobin Digestion Genes Are Conserved in Lizard‐Infective Plasmodium Species With Different Host Cellular Niches

Ecology and Evolution, Volume 16, Issue 6, June 2026.
Despite their evolutionary relatedness to malaria parasites that infect humans, wildlife Plasmodium—particularly those that infect birds and lizards—are understudied, leaving their vast genetic diversity to be explored. By assembling parasite transcriptomes from Plasmodium‐infected lizard blood, we provide the first evidence that lizard‐infective ...
Sarah J. Pangburn, Janus Borner, Sidhanth Misra, Jessica Zavalunova, Susan L. Perkins   +4 more
wiley   +1 more source